Abilify- Stanford Clinic Patients

[MartinK]

Please, all Abilify experienced people - Can it take a while for Abilify to increase my energy levels?
Extreme fatigue (Im bedridden) is my main problem together with severe PEMs. I started Abilify almost a month ago and now Im on 0.50 mg. I'm still waiting for the energy effect...

Please can you motivate me and describe your experience?
Did your energy improve only on higher doses?

How long did it take for the energy improvement to appear? And what was the dose? I don't want to increase quickly because once it has already caused me restlessness, insomnia and anxiety.

 

[jaybee00]

For me it was quick—about a week—dose probably 0.5 mg initially.

 

[DonPepe]

5 to 7 days with me at around 0.5mg. Responders seem to have different sweet spots. You may need a slightly higher dose.

 

[DonPepe]

Yes. 0,4 mg Abilify + only 3 mg Solian.

Hi

How is the abilify going? Are you still taking it? Are you still taking the Amisulpride combo?

 

[nsdn]

Hi

How is the abilify going? Are you still taking it? Are you still taking the Amisulpride combo?

Yes, everything is fine. I take 4 Abilify and 3 Amisulpride. To keep prolactin levels from rising, I take vitamin E once a day and 50 mg of B6 twice a day.

 

[DonPepe]

Yes, everything is fine. I take 4 Abilify and 3 Amisulpride. To keep prolactin levels from rising, I take vitamin E once a day and 50 mg of B6 twice a day.

Is that 4mg of Abilify and 3mg of Amisulpride you are taking? I’m confused.

 

[nsdn]

Is that 4mg of Abilify and 3mg of Amisulpride you are taking? I’m confused.

Yes

 

[Dude]

I always consider which medications might be effective for ME/CFS and how they could fit into Prof. Dr. Klaus Wirth’s hypothesis. He has already provided an explanation for LDN. However, I have not yet been able to understand the mechanism of action for Abilify.

Then I came across the following publication:
https://link.springer.com/chapter/10.1007/978-3-319-24750-2_17?utm_source=chatgpt.com

It describes how dopamine is capable of modulating the sodium-pottasium pump. This could be a clue to explaining how Abilify works in ME/CFS.

 

[light24bulbs]

Hi all, I am considering asking my doctor for LDA to supplement my LDN to target the dysautonomia-related neurological symptoms I have been experiencing like POTS, sleep disturbance, anxiety, and temperature regulation.

The last few months have been rough due to those issues and I would love a two month boost to try to get to a better baseline. However, I don't want to be left in a worse place than where I started. As far as I can tell, the Abilify tollerance/lifespan isn't associated with some sort of withdrawal or crash at the end, but I wanted to double check that those who've tried Abilify haven't felt that it's left them worse off, and would still recommend doing it. I also wanted to gather reports about combining it with LDN, as I'm on an ultra-low naltrexone dose of .2mg/day.

Thanks,
Forrest

 

[light24bulbs]

Apparently Bupropion doesn’t even inhibit DAT at all in people. If it raises dopamine at all it would be through NRI or other mechanisms.

@leokitten i would be afraid to try rexulti at this point. A study I read showed that abilify, rexulti and Cariprazine all inhibited Complex 1 of the ETC and inhibited mitochondrial respiration, causing necrosis of neurons, especially in the motor control area of the brain, explaining their apparent highly prevalence of causing movement disorders. They didn’t test whether a D2/D3 antagonist reversed the damage so not sure if it’s dopamine receptor dependent but yeah, those drugs are all apparently just straight up toxic

Woah..what if abilify works _because_ it supresses mitochondrial resperation. Anyway, that is pretty darn terrifying if true.

 

[JES]

Woah..what if abilify works _because_ it supresses mitochondrial resperation. Anyway, that is pretty darn terrifying if true.

Why would it help ME/CFS if it suppresses mitochondrial respiration? Let's not forget that Abilify in ME/CFS is used in low dose, not in the normal dose used for psychiatric disorders. Side effects are usually dose-dependent and sometimes a drug can even work in a paradoxically different way in low-dose administration compared to normal dose.

For example, LDN seems to boost endorphin levels, but at normal dose, naltrexone is used to manage alcohol or opioid abuse by blocking those same endorphins.