Abilify- Stanford Clinic Patients
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hmnr asg
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more activating in my experience. Abilify was only activating in the initial two weeks. After that I just felt like my cfs had diminished. Vraylar is causing me insomnia. I have reduced my dose to 1.5 every other day and it has gotten better.
As for helping with cfs i have no idea! its either zero benefits or tiny, definitely nothing like the honeymoon phase I had with abilify.
JES
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Found this:
Conclusion: Amongst the SSRIs examined, only fluoxetine acutely increases extracellular concentrations of norepinephrine and dopamine as well as serotonin in prefrontal cortex, suggesting that fluoxetine is an atypical SSRI (reference).
As the SSRI fluoxetine can inhibit dopamine reuptake at high concentrations (Sánchez and Hyttel, 1999), it is possible that the enhanced dopaminergic modulation could be caused by its direct action on the dopaminergic neurons (reference).
Not sure what to make of it other than dopamine receptors are indeed affected at least to some degree by fluoxetine. FYI, citalopram or escitalopram is the SSRI that is most selective and theoretically should have the least effect on dopamine.
Are you getting akathisia? I might want to try Vraylar sorry for asking all the questions.
btw I’m not taking fluvoxamine anymore, have been on fluoxetine for over a month and sticking with that after trying many antidepressants. Nothing was wrong with fluvoxamine it didn’t virtually any side effects which was great, but at least for me has a weaker antidepressant effect. Fluoxetine also had no side effects but seems to be stronger and has a greater anti-anxiety and antidepressant effect.
hmnr asg
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Not really, im not. I really cant think of any side effects at this dose of 1.5mg every other day.
Glad prozac is working for you! for some reason it significantly worsened my trigeminal neuralgia pain when i tried it a few years ago. I'm still on duloxetine
ps if you want to ask more about vraylar you can also dm me.
Has anyone who developed tolerance to Abilify after a few months ever tried taking one of the safer dopamine antagonists like ziprasidone for example for a few months to try and reverse tolerance? This would give a lot of insight as to what part of Abilify’s MOA is causing at least temp relief of ME symptoms?
What about this TD med—“ By selectively reducing the ability of VMAT2 to load dopamine into synaptic vesicles,[8] the drug reduces overall levels of available dopamine in the synaptic cleft, ideally alleviating the symptoms associated with dopamine hypersensitivity. ”
https://en.wikipedia.org/wiki/Valbenazine
Seems relatively safe.
https://en.wikipedia.org/wiki/Valbenazine
Seems relatively safe.
I think though this isn’t generic yet, but it’s a good idea
Inhibition of VMAT2 by β2-adrenergic agonists, antagonists, and the atypical antipsychotic ziprasidone, Stove et al, 2022
In addition to ziprasidone there are other generic drugs people could try to inhibit VMAT2 for a while and possibly reverse Abilify tolerance.Sorry just want to go back a bit, why would VMAT2 inhibition potentially reverse LDA tolerance in pwME?
nsdn
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Yes. 0,4 mg Abilify + only 3 mg Solian.
I have been given samples of Rexulti (Brexpiprazole) to try, but I've read a lot of horror stories about it, so I don't know if it's worth trying. Also crazy expensive for no reason, like many drugs in the US. If it has a possibility of helping with ME/CFS, it could be worth a shot, but I've seen little to no evidence that it does (unless anyone can tell me any Rexulti success stories they have heard?). It was given to me for depression, not ME/CFS, but I don't even know if it would be effective for depression on it's own, as it's supposed to be used adjunct and antidepressant.
thank you! Sorry for bumping this older thread.
thank you! Sorry for bumping this older thread.
serafim
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what kinda horror stories?
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Yes it worked for my CFS symptoms almost as well as Abilify did. I started at 0.25mg, it took about 3 days to notice the effects! Good luck
Do you also take Metformin?
A question for anyone who knows; has this phase III study been completed? ..do we know anything more than in 2020 about this drug?But for me personally sharing what helps feels a bit like being in a defensive situation. I’m not a bio chemist and I’m sorry I can’t tell you more but what I know from Stanford. Then you just have to wait until a phase III study is successfully completed
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Has anybody tried to augment or to restore LDA by adding 1 mg LDN twice a day, as shown in this paper on a small proof of concept study on augmentation of dopaminergic antidepressants?
https://www.sciencedirect.com/science/article/abs/pii/S0165032716304499
"Filamin A is also found in dopaminergic D2 and D3 receptors, which led Bear and Kessler to propose that low (LDN) or ultra-low (ULDN) doses of naltrexone might reverse or prevent desensitization to D2/3 agonists."
D2 re-sensitization seems to be interesting in the case of LDA pooping out.
https://www.sciencedirect.com/science/article/abs/pii/S0165032716304499
"Filamin A is also found in dopaminergic D2 and D3 receptors, which led Bear and Kessler to propose that low (LDN) or ultra-low (ULDN) doses of naltrexone might reverse or prevent desensitization to D2/3 agonists."
D2 re-sensitization seems to be interesting in the case of LDA pooping out.