Welcome to Phoenix Rising!
Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
To become a member, simply click the Register button at the top right.
more activating in my experience. Abilify was only activating in the initial two weeks. After that I just felt like my cfs had diminished. Vraylar is causing me insomnia. I have reduced my dose to 1.5 every other day and it has gotten better.@hmnr asg did you find Vraylar more activating or less activating than Abilify?
Found this:Though there is one major difference between my situation this time and the previous two times. Before I’d been on moclobemide 600 mg but this time I’ve been taking fluoxetine 60 mg per day. Could fluoxetine or any SSRI for that matter reduce Abilify’s effects or worse could this mean Abilify with each cycle is starting to not work? Ugh, I really don’t want to come off fluoxetine to test what’s going on it has a very long half life.
Are you getting akathisia? I might want to try Vraylar sorry for asking all the questions.more activating in my experience. Abilify was only activating in the initial two weeks. After that I just felt like my cfs had diminished. Vraylar is causing me insomnia. I have reduced my dose to 1.5 every other day and it has gotten better.
As for helping with cfs i have no idea! its either zero benefits or tiny, definitely nothing like the honeymoon phase I had with abilify.
btw I’m not taking fluvoxamine anymore, have been on fluoxetine for over a month and sticking with that after trying many antidepressants. Nothing was wrong with fluvoxamine it didn’t virtually any side effects which was great, but at least for me has a weaker antidepressant effect. Fluoxetine also had no side effects but seems to be stronger and has a greater anti-anxiety and antidepressant effect.That is such a coincidence, I am switching to fluvoxamine as well! I am very scared it might have sedation as a side effect (which i cant afford).
How are you doing with fluvoxamine? is it sedative? any help with the anxiety?
Not really, im not. I really cant think of any side effects at this dose of 1.5mg every other day.Are you getting akathisia? I might want to try Vraylar sorry for asking all the questions.
Glad prozac is working for you! for some reason it significantly worsened my trigeminal neuralgia pain when i tried it a few years ago. I'm still on duloxetinebtw I’m not taking fluvoxamine anymore, have been on fluoxetine for over a month and sticking with that after trying many antidepressants. Nothing was wrong with fluvoxamine it didn’t virtually any side effects which was great, but at least for me has a weaker antidepressant effect. Fluoxetine also had no side effects but seems to be stronger and has a greater anti-anxiety and antidepressant effect.
What about this TD med—“ By selectively reducing the ability of VMAT2 to load dopamine into synaptic vesicles,[8] the drug reduces overall levels of available dopamine in the synaptic cleft, ideally alleviating the symptoms associated with dopamine hypersensitivity. ”
https://en.wikipedia.org/wiki/Valbenazine
Seems relatively safe.
What about this TD med—“ By selectively reducing the ability of VMAT2 to load dopamine into synaptic vesicles,[8] the drug reduces overall levels of available dopamine in the synaptic cleft, ideally alleviating the symptoms associated with dopamine hypersensitivity. ”
https://en.wikipedia.org/wiki/Valbenazine
Seems relatively safe.
what kinda horror stories?I have been given samples of Rexulti (Brexpiprazole) to try, but I've read a lot of horror stories about it, so I don't know if it's worth trying. Also crazy expensive for no reason, like many drugs in the US. If it has a possibility of helping with ME/CFS, it could be worth a shot, but I've seen little to no evidence that it does (unless anyone can tell me any Rexulti success stories they have heard?). It was given to me for depression, not ME/CFS, but I don't even know if it would be effective for depression on it's own, as it's supposed to be used adjunct and antidepressant.
thank you! Sorry for bumping this older thread.
Yes it worked for my CFS symptoms almost as well as Abilify did. I started at 0.25mg, it took about 3 days to notice the effects! Good luckI have been given samples of Rexulti (Brexpiprazole) to try, but I've read a lot of horror stories about it, so I don't know if it's worth trying. Also crazy expensive for no reason, like many drugs in the US. If it has a possibility of helping with ME/CFS, it could be worth a shot, but I've seen little to no evidence that it does (unless anyone can tell me any Rexulti success stories they have heard?). It was given to me for depression, not ME/CFS, but I don't even know if it would be effective for depression on it's own, as it's supposed to be used adjunct and antidepressant.
thank you! Sorry for bumping this older thread.
Do you also take Metformin?Yes. 0,4 mg Abilify + only 3 mg Solian.
A question for anyone who knows; has this phase III study been completed? ..do we know anything more than in 2020 about this drug?But for me personally sharing what helps feels a bit like being in a defensive situation. I’m not a bio chemist and I’m sorry I can’t tell you more but what I know from Stanford. Then you just have to wait until a phase III study is successfully completed