I think you are right! Normally the drug is taken in a much higher dose for all those other effects.doesn't schizophrenia have something to do w histamine malfunction (high histamine, or problems breaking it down or both, etc.)?
The anti-inflammatory effect of Abilify has been studied.Aripiprazole exhibits high affinity for dopamine D2 and D3, serotonin 5-HT1A and 5- HT2A receptors (Ki values of 0.34, 0.8, 1.7, and 3.4 nM, respectively), moderate affinity N H N N CH2CH2CH2CH2O O Cl Cl 2 of 39 for dopamine D4, serotonin 5-HT2C and 5-HT7, alpha1-adrenergic and histamine H1 receptors (Ki values of 44, 15, 39, 57, and 61 nM, respectively), and moderate affinity for the serotonin reuptake site (Ki=98 nM). Aripiprazole has no appreciable affinity for cholinergic muscarinic receptors (IC50>1000 nM). Aripiprazole functions as a partial agonist at the dopamine D2 and the serotonin 5-HT1A receptors, and as an antagonist at serotonin 5-HT2A receptor.
In low doses Abilify is used to treat chronic pain as well. I suspect this is one of the reasons it was prescribed to me.
Stanford seems to prefer prescribing the non-generic name brand version. It seems this Japanese drug has a number of other off-label uses.
Anecdotal stories on the Stanford ME/CFS FB page (Montoya Patients): less brain fog, able to do small tasks when were completely bed-bound before, small increases in energy. No-one has been on for a very long time, so stories are based on a short time span on drug. But hey any good news is welcome. Do a search on FB for Stanford ME/CFS page and join group to see posts.What kind of success is there with this drug? Which symptoms does it lessen?
Anecdotal stories on the Stanford ME/CFS FB page (Montoya Patients): less brain fog, able to do small tasks when were completely bed-bound before, small increases in energy. No-one has been on for a very long time, so stories are based on a short time span on drug. But hey any good news is welcome. Do a search on FB for Stanford ME/CFS page and join group to see posts.
Let's hope the side effects are kept to a minimum because the doses of these medications are quite low in most cases.this sounds like the adult ADD/ADHD forums, when they took the usual suspects (vivanse, ritalin and other stronger stuff).
it seemed, that many would develop strange/unwanted side effects quite quickly, and sooner or later end up with more drugs: anti-depressant, then anti-anxiety, in between IBS-problems...
From recent research I've read that is right, there is no medication that has been developed for brain inflammation.Hello Navid: I don't know much about various pharmaceuticals in existence, however, if the idea is to lower brain inflammation, am I to assume now that there is not medication out there designed just for this problem--brain inflammation
I would assume that Stanford would run appropriate tests on the patient's P450, and that they wouldn't be spinning the chamber without good base research
Interestingly I ran into a guy with an inflammatory condition triggered by histamines. He decided to try a diet of exclusively histamine free meat, this seems to have cured him of most of his symptoms. Apparently histamines are found in a lot of foods. I can't imagine a diet of steak everyday.doesn't schizophrenia have something to do w histamine malfunction (high histamine, or problems breaking it down or both, etc.)?
The Stanford people also prescribed abilify for me but because I was taking cymbalta I thought maybe I should wait until after I quit cymbalta ( I have been trying to wean myself off of it because of the size effects and it's been hell).
Thanks for the link @Learner1 ! According to the info in the link it may help to selectively block leukotriene biosynthesis - which may help MCAS patients with high leukotrienes. Maybe that's why it can also help in rheumatoid arthritis.
5 YEARS??I'm on Cymbalta, max dose 120mg, too. When I looked it up, it said there was "moderate" interaction between Cymbalta and Abilify. Yes, it is SOOOO difficult to wean off Cymbalta. If I'm even a couple hours late with my dose, I can start to feel brain zaps. Maybe 6 months ago, I read an article about a man, a physician I think, who wrote all about Cymbalta and getting off of it. He was literally opening up the capsule and taking out 1 bead at a time. If I remember correctly, he gave himself a 5 year timeline to titer down (!) I really feel for you doing this.