A treatment that helps me tremendously

[pamojja]

I don't see any merit in your theory, as no two individuals share the same genetics or epigenetics, and their responses to medication can vary significantly.

My understanding is, that due to biochemical individuality - different medical history, different toxic exposures, different diet and lifestyles, different genetics, etc. - every person has different nutrients needs. There was a whole chapter on biochemical individuality in Linus Paulings book: 'How to live healthier and feel better'. Reposted here under a spoiler: https://forums.phoenixrising.me/threads/high-dose-vitamin-c-mystery.93203/post-2477035 Some might not even have the need to supplement.

I'm opposing any supplementation without at least the most rudimentary lab tests. If he only checked serum calcium, your neighbor would have caught hypercalcemia in its early stage, where it would have been easy to reverse. Instead, most supplement calcium even without knowing their serum calcium results. Usually, hypercalcemia is corrected by surgical removal of the parathyroid gland. If you don't believe me, fine, but you could see for yourself if there are any case reports in the scientific literature of kidney removal solely due to hypercalcemia. Kidney removal may be considered in end-stage renal disease, infection or cancer only.

Would you dismiss their experience or accuse them of lying?

I don't dismiss anything well-informed. Otherwise, it's not lying at all, but simply not self-informed enough. About exact vitamin D and calcium intakes, their serum levels leading up to hypercalcemia, and the real issue, why his kidney was removed, in this case. Removing a kidney just because of hypercalcemia is just not standard of medical practice.

Again: https://newsnetwork.mayoclinic.org/...ed-hypercalcemia-can-lead-to-health-problems/ My CKD stage 1 was also not caught by a physician, but by myself by using a CKD online calculator from all my kidney lab markers. Otherwise no symptoms.

 

[SWAlexander]

dismiss anything well-informed

Your interpretation is arbitrary.​

Use of vitamin D drops leading to kidney failure in a 54-year-old man​

https://www.cmaj.ca/content/191/14/e390

 

[pamojja]

Use of vitamin D drops leading to kidney failure in a 54-year-old man

Just as I said, serious comorbidities and medications (which I refused due to their almost certain side effects):

He had recently returned from a trip to Southeast Asia, where he had spent extensive periods sunbathing (6–8 h/d) for 2 weeks. His medical history included hypertension, dyslipidemia and gout, for which he was taking perindopril 8 mg daily, rosuvastatin 10 mg daily, amlodipine 10 mg daily, indapamide 2.5 mg daily and febuxostat 80 mg daily.

Even more comorbidities:

The differential diagnosis at this point included hypercalcemia of malignancy, multiple myeloma and granulomatous diseases, such as sarcoidosis. A renal biopsy showed features of nephrosclerosis and microcalcifications but with no features of sarcoidosis or light chain deposition

All those multiple comorbidities and their polypharmacy, of course make the assessment, that usual hyperglycemia of vitamin D3 overdose only starts at about 200 ng/ml untrue.

At the nephrology clinic, the patient’s measured 1,25 dihydroxyvitamin D3 level was 274 pmol/L and his 25-hydroxyvitamin D3 level was 241 nmol/L (Box 1).

Which converts to 96.4 ng/mL, a within normal level at my laboratory, which without so many comorbidities, could not cause hypercalcemia by itself alone.

The patient’s calcium and vitamin D levels decreased after initiation of hydroxychloroquine. Almost 1 year after diagnosis, his calcium and vitamin D levels have returned to normal, but he is left with stage 3B (estimated glomerular filtration rate 34 mL/min/1.73m3) chronic kidney disease.

This patient was really lucky. Though without all those comorbidities, early caught hypercalcemia is easily reversible. But in this case, I'm honestly surprised he survived with so many so serious conditions. Even in such a complex situation, with a lot of good luck, still no removal of the kidney.

He had recently returned from a trip to Southeast Asia, where he had spent extensive periods sunbathing (6–8 h/d) for 2 weeks. ... over a period of 2.5 years, he took 8–12 drops of vitamin D daily, for a total daily dose of 8000–12 000 IU.

I took 8,000 IU for almost 17 years now. On my yearly vacations during winters to a South-Indian beach I get about 4 hrs/d whole-body sunshine exposure for 6-7 weeks. Experienced improbable remissions only.


This is not a case study of vitamin toxicity by hypercalcemia alone, but clearly co-factored by a multitude of serious dysfunctions leading to CKD, including hypercalcemia of malignancy.

As already said, fine with me if you don't want to believe that vitamin D toxicity - easily reversible hypercalcemia - is extremely difficult to reach with even 10,000 IU per day. Almost impossible if all precautions are taken, by monitoring vitamin D and calcium levels, as widely recommended above 5,000 IU/d.

Your interpretation is arbitrary.

I have remained consistent. For hypercalcemia by vitamin D3 supplementation alone, no case study without comorbidities is found. Consecutive kidney removal, neither.

By the way, my CKD stage 1 was caused by former use of Ibuprofen.

 

[Johannes]

I assume your nutritionist includes Vit D lab tests?

No. Vit D was calculated from what I eat. Lab tests can't separate vit D coming from food from that what comes from supplements. My doctor however, did ask me to have lab tests at that time.

 

[Johannes]

Which converts to 96.4 ng/mL, a within normal level at my laboratory, which without so many comorbidities, could not cause hypercalcemia by itself alone.

In my lab the limit for toxicity is 375nmol/l (150ng/ml) but that limit is too low. In a long term (7 year) German study they found out that a lot higher levels are safe.

@SWAlexander, kindly read this stydy. Patrick J.McCullough Douglas S. Lehrer Jeffrey Amend, Daily oral dosing of vitamin D using 5 000 to 50 000 international units per day long term hospitalized patients: insights from a seven year experience. The journal of steroid biochemistry and molecular biology 189/2019, ss 228-239

That study is found from here:
https://www.sciencedirect.com/science/article/abs/pii/S0960076018306228

According to that study dosages between 5 000 IU and 60 000 IU resulted levels of 100ng/ml - 384ng/ml (250nmol/l - 958nmol/l) respectively without toxicity or hypercalsemia.