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Methylated Bs.
Creatine.
Phosphatidylcholine.
Trimethylglycine.
SAMe.
What else?
Creatine.
Phosphatidylcholine.
Trimethylglycine.
SAMe.
What else?
I don't believe there is such a thing as overmethylation. Methylation is one of the most important biochemical reactions in the body. It's necessary for life! So I find it hard to believe you can have too much methylation.
What I believe you can have is an imbalance in the methylation cycle which causes problems with neurotransmitters and hormones that cause the symptoms of "overmethylation".
For example, the imbalance can be between homocysteine and methionine (SAMe/SAH). Too much SAMe and you have a problem, not because you have too much SAMe (which is one of the most important chemicals in the body for health) but because something downstream isn't degrading e.g. hormones, dopamine, adrenaline, serotonin, etc. which causes the symptoms of "overmethylation".
Although substance that is meant to absorb the excess methyl groups, glycine, gave me enormous relief.
Well, unfortunately, testing is how you figure out what going on and how best to correct it.Unfortunately I cannot get the testing done because of the pandemic. Testing companies are not shipping to India.
What I do know is that these substances wrecked havoc in my health. Although substance that is meant to absorb the excess methyl groups, glycine, gave me enormous relief.
Unfortunately I cannot get the testing done because of the pandemic.
Methylated Bs.
Creatine.
Phosphatidylcholine.
Trimethylglycine.
SAMe.
What else?
Well, unfortunately, testing is how you figure out what going on and how best to correct it.
Wondering if you are deficient in B1 or molybdenum, used in the transsulfuration pathway after methylation. Or maybe you were just short of glycine, needed to make glutathione, so things were backing up behind that step. Or, maybe you're toxic with something so that the glutathione you were making was mobilizing it.
In case of no access to testing, one of course can test different nutrents, their combinations and effects. Just as you did and thereby found out:
However, without access to testing its always worthwhile to start with really the lowest possible doses of any new supplement (even by splitting caps and pill into tiny parts), and only gradually increase over weeks, months and years. Might be if you followed such a very slow increasing strategy - you would have found some of those nurtrients have a threshold only above which your unable to tolerate.
And by introducing co-factor nutrients in the same way, those limits of tolerace could change. For example had 300mg tolerance limit of choline. By gradually introducing inositol that intolerance meanwhile completely lifted (years later).
Also glycine in most diets is very deficient, and in this case just replenishing it alone could have the benefits you experience. You also could try high-dose nicotinc acid (though again: start very low dose, like below 50mg, and increase very gradually every few days) which could eat up all the excess methylation donors.
Finally, though advanced testing isn't available to many of us (due to high costs and repeated need), one can find many hidden suggestions in just regular blood-test done very cheaply in any Indian laboratory. Like lipid + glucose metabolism markers, Liver and kidney function markers, Thyroid hormones like the most important freeT3, or whatever else available (cortisol, dheas, testosterone..), all the electrolytes including ferritin, vitamin 25(OH)D, complete blood count, etc. Always get it there myself, because alltogether just IRs ~2000,-.
Members here might be able to spot some issues in your blood-test results, a regualar doc wouldn't even mention.
What your average diet contains?
edit: if available a homocysteine test too (has to be centrifuged right after the blood-draw)
I do my best to intake eggs or meat every once in a while.
I know by now my Homocysteine would be within range.
I also got my B complex tested. I was deficient in thiamine.
Thank you for your insight. I am always looking forward to learn more for the betterment of my health.
What I do know is that these substances wrecked havoc in my health. Although substance that is meant to absorb the excess methyl groups, glycine, gave me enormous relief.
I am actually able to tolerate all these substances very well now. I no longer believe that I am an overmethylator, but I believe that I was a severe case of Undermethylation.
As I supplied my body with methyl donating substances, it brought some changes which were quite difficult to tolerate initially. Hence I believe I was severely undrtmethylated.
I took large doses of riboflavin, 400 mg a day for months, and I think it safely fixed my methyl group shortage, and I find that I can easily tolerate all the above mentioned substances now.