In case of no access to testing, one of course can test different nutrents, their combinations and effects. Just as you did and thereby found out:
However, without access to testing its always worthwhile to start with really the lowest possible doses of any new supplement (even by splitting caps and pill into tiny parts), and only gradually increase over weeks, months and years. Might be if you followed such a very slow increasing strategy - you would have found some of those nurtrients have a threshold only above which your unable to tolerate.
And by introducing co-factor nutrients in the same way, those limits of tolerace could change. For example had 300mg tolerance limit of choline. By gradually introducing inositol that intolerance meanwhile completely lifted (years later).
Also glycine in most diets is very deficient, and in this case just replenishing it alone could have the benefits you experience. You also could try high-dose nicotinc acid (though again: start very low dose, like below 50mg, and increase very gradually every few days) which could eat up all the excess methylation donors.
Finally, though advanced testing isn't available to many of us (due to high costs and repeated need), one can find many hidden suggestions in just regular blood-test done very cheaply in any Indian laboratory. Like lipid + glucose metabolism markers, Liver and kidney function markers, Thyroid hormones like the most important freeT3, or whatever else available (cortisol, dheas, testosterone..), all the electrolytes including ferritin, vitamin 25(OH)D, complete blood count, etc. Always get it there myself, because alltogether just IRs ~2000,-.
Members here might be able to spot some issues in your blood-test results, a regualar doc wouldn't even mention.
What your average diet contains?
edit: if available a homocysteine test too (has to be centrifuged right after the blood-draw)