can you tell me what are the signs/symptoms of neurological damage that would respond to this high dose b12?
This is the best description. It is mostly directly based on people who have done this in the context of the Active B12/folate protocol.
Approximate timing of my startup of individual items that being considered here, this gives a quite distinctive pattern for each nutrient or set of nutrients: 03/04/13, Version 1.1
Others mentioned similar patterns and variations.
1. Initially – Mecbl
2. +5 months 400mcg SAM-E
3. + 4 months AdoCbl
4. + 3 months titrate +50mg zinc
5. +4 years 400mcg Metafolin
6. +1 year LCF
7. + 1 month TMG 1000mg/day
8. 30mg total of MeCbl injections (3 or 4) daily,
9. +0 Reduce SAM-e to 200mcg
10. + 4 years remove TMG
11. +6 months increase SAM-E to 800mcg
12. Next 1 year titrating Metafolin and finding all the reasons I get folate insufficiency, early partial methylation block by effect.
These symptoms are what responded very well to CNS penetrating doses of MeCbl either as 50mg sublingual single 4-5 hour dose or 4 x 7.5mg or 3 x 10mg or for some 2 x 15mg subcutaneous MeCbl injections. Metafolin in some way enhances retention of AdoCbl and MeCbl with excretion visibly decreased. A sublingual dose of 1-2 tablets each hour added for 12 hours appears to generate substantial CNS penetration as well.
CNS penetrating dose MeCbl – AdoCbl – Metafolin – Omega-3 oils
Elevated CSF Hcy
Low CSF cobalamin
limbs feel stiff
Drowsy
CNS penetrating dose MeCbl – AdoCbl
dimmed vision - usually not noticed going into it because change can be very slow or present for life
Clumsiness
CNS penetrating dose MeCbl – AdoCbl - Metafolin
Slow to adapt to night vision
CNS penetrating dose MeCbl – AdoCbl – Metafolin – LCF
Difficulty in word finding
CNS penetrating dose MeCbl – AdoCbl – Metafolin – Omega-3 oils
Brainstem or cerebellar signs or even reversible (with mb12) coma may occur
demyelinated areas on nerves
subacute combined degeneration
axonal degeneration of spinal cord
unsteadiness of gait
ataxic gait, particularly in dark
positive Romberg
positive Lhermittes
Loss of motor control over some or all of toes
Loss of motor control over part or all of feet
Loss of sense of joint position
sudden electric like shocks/pains shooting down arms, body, legs shooting down from neck movement
sudden "ice pick" pain
decreased reflexes
brisk reflexes
Foot Drop
tripping over toes
injuring toes catching top of toes on floor
general feeling of weakness