Just so everyone will get a perspective what I, the "controversial, manipulative" person write about.
I have Google translated one post from my blog:
For researchers and treating physicians about ME / CFS
By Mats Lindström January 6, 2016
I have compiled what I find most interesting about the disease ME / CFS in some parts, even fibromyalgia. The purpose of this compilation is of course that my hope is that more will be done for these patient groups in Sweden. I hope there can be some benefit.
Examples of what we know about ME / CFS
ME / CFS is an extremely complex disease. But there are some tracks to immerse themselves in. The immune system has been the subject of medical research, especially in recent years. Several interesting research projects underway.
The discrepancies identified have included low / low activity of natural killer cells (NK cells), and increases in various types of "cytokines" that regulate the immune system. Some of these immune abnormalities are also consistent with cancer.
Immune Signatures
Researchers at Columbia University (Mady Hornig et al) discovered last year "distinct immune signatures" in the blood of ME / CFS patients and immune changes in the central nervous system. There is still much more to learn and a pressing issue is how immunological measurements change over time, they also relate to the severity of the disease.
Researchers at Griffith University in Queensland, Australia have examined these issues for several years, and their latest report compares groups of innate and adaptive immune cells in both moderate disease (variable) and our sick (home-bound) patients. They used a set of performance indicators to measure the severity of the disease, including classic self cat ing scales such as Bell Disability Scale.
The researchers found some changes in the immune cells and their receptors over time, particularly in certain natural killer cell receptors. However, a key finding was that people with severe ME / CFS have been significant changes in four key immune categories:
1. Invariant natural killer T cells (NKT cells) - increased compared with healthy controls
2. markers on CD8 + T cells - increased compared to moderately ill
3. Natural killer cell receptors (NK-cell activity) - decreased compared to healthy controls and moderately ill.
4a. γδ T2 cells - increased compared with healthy controls and moderately ill
4b. γδ T1 cells - decreased compared to healthy controls and moderately ill
Natural killer cell receptors (NK cells) particularly important for the immune system
One of the most consistent abnormalities reported in ME / CFS patients over the past 20 years is that NK cells have a lower activity than in healthy people. NK cells play a key role existing tumor cells and virus-infected cells. A reduced activity means obviously a weakened immune system.
A likely explanation for most of the differences in immune cells or receptors in severely ill ME / CFS patients is an ongoing immune activation in response to an infection. This could explain the elevated CD8 + T cell numbers and other findings, such γδ T cells changes; as the authors point out.
The scientific literature on ME / CFS and CFS contains about 6800 publications, but few have touched the details of critically ill patients.
Other known anomalies
CD4 + T cells
We know that there are changes in the CD4 + T cells which can turn off the T-cell mediated immunity at the end of a immune reaction and suppress autoreactive T cells. According to the study below, they also impact on methylation.
Neuro inflammation in ME / CFS and Fibromyalgia patients
So far, a study of neuro-inflammation in ME / CFS patients made - Nakatomistudy found evidence of neuroinflammation in the cingulate cortex, hippocampus, amygdala, thalamus, midbrain and ponsregioner in the brain. The fact that the degree of the widespread neuro-inflammation was strongly correlated with the severity of fatigue, pain, cognitive problems and depression that were in the ME / CFS group were positive. The Japanese study has found evidence of extensive inflammation in the brains of ME / CFS patients. The inflamed areas regulate the reticular activating system, which affects alertness, sensitivity to pain, cognitive impairment and mood.
Gene mutation in the MTHFR 677 and 1298
Gene mutation in the MTHFR 677 and 1298 is relatively common. Vitamin B12 and folic acid are more difficult to be converted to methylated form. Hence it can be so that those who have gene mutation feel better subcutaneously methylcobalamine and that perhaps should use methylfolate instead of folic acid. It is estimated that about half of all people with ME / CFS who feel better with this type of treatment although it can not be demonstrated any lack of B12 / B9 in blood. It seems unusual to take MTHFR test in Sweden.
Lactate in the brain
Researchers in New York have measured the levels of a metabolite called lactate in the cerebrospinal fluid (the fluid that surrounds the brain and spinal cord) of 19 ME/CFS patients, 31 people with major depression and 23 healthy controls.
The average lactate levels were highest in the ME / CFS group (0.92 units) compared to healthy subjects (0.04). The group with depression had an intermediate level (0.40). In addition, the researchers found a significant correlation between lactate and mental fatigue in ME / CFS patients, but not in depressed patients or healthy controls.
Source (p. 13 of the PDF)
Heart rate variability
Dr. Benjamin Natelson and Fumharu Togo undertook in 2013 a study of 52 female ME / CFS patients and saw the correlation between heart rate variability (HRV) and subjective sleep quality. The 52 female patients showed signs of sleep disorders in the form of greatly reduced total sleep time, decreased sleep efficiency, and changes in HRV compared with matched healthy controls.
Vitamin and mineral deficiencies
Many often have low levels of vitamin D. Deficiency include magnesium, zinc, calcium, potassium and iron are present.
Low blood volume = POTS
The evidence suggests that a majority of ME / CFS patients have low blood volume (hypovolemia) causing POTS, a disease characterized by orthostatic intolerance, which many people with ME / CFS have problems.
Hormone imbalance
It is common with the imbalance in the endocrine system. High TSH levels occur. Low DHEA and cortisol levels may be present. It is uncertain when few have undergone such tests.
The imbalance in the gut - Dysbiosis
Low number of lactobacilli and the high number e.colibakterier seems to be prevalent among the ME / CFS patients undergoing bowel foreign samples (not normally offered in Sweden). Incidence of imbalances in the intestinal flora (dysbiosis) among ME sufferers appear to be more the rule than the exception. There is indication that many people with ME / CFS also have high histamine levels, which can be due to lack of DAO enzyme. Food hypersensitivity and even allergies are fairly common.
AMPK enzyme
Researchers in Britain have found that patients with ME / CFS (Fukuda) has a defect in a molecule associated with the production of a protein called AMP kinase (AMPK). The enzyme is important for endurance in the muscles. Quercetine and medicine for diabetes 2 (Metformin Bluefish) have been shown to influence the activity of AMPK enzyme.
Post-Extertional Malaise (PEM) demonstrated - Variations in oxygen uptake
At the two-day cycle test is a significant difference of impaired syreupptagningsförmåga.De most important measurements is the aerobic capacity (VO2peak) and oxygen uptake at anaerobic threshold (VO2AT).
Post-Extertional Malaise (PEM) demonstrated - Intestinal bacteria are reflected in blood after physical exertion
Increased incidence of intestinal bacteria was reflected in ME / CFS patients' blood for up to 48 hours after the cycle test. Rifaximin may help some.
Heat Shock Protein 60 - autoimmunity?
Professor Jonas Blomberg have found an increased frequency of a particular type of auto-antibodies directed against a portion of the antigen.
Cytokine-abnormalities
We know that there is too much of several pro-inflammatory cytokines eg IL-1, IL-6 and IL-17A (Hornig). Fibromyalgia patients have been shown to have 3-fold higher levels of IL-8 (Kadetoff). That ME / CFS is thus a neuro-inflammatory disease seems to me to be quite obvious. It is unclear what causes inflammation. Right now, a study in the Netherlands concerning the IL-1 inhibitors. The study is reported in the spring / summer, 2016.
IL-10
We know that there are lower levels of IL-10, which is an anti-inflammatory cytokine
Mold Toxins common
104 of 112 pcs (93%) ME / CFS patients (JML Fukuda) had mycotoxins in the urine, compared with 0% in healthy control group.
The immune system's role
Most patients with ME / CFS have been diagnosed with the illness, a severe infection or after several infections that succeeded each other. In some cases, even after vaccinations and trauma. The question is whether these infections / loads can lead to parts of the immune system simply becomes weakened and / or lead to autoimmunity. I am no stranger to the non-specific immune system can go on the back burner while the specific may go on apace. The balance can be disturbed. It need not necessarily be so. However, indications are that it is non-specific immune system is weakened in cases ME / CFS developed.
Typical of the non-specific immune system is that it is the body's first line of defense against a pathogen. It responds quickly and can recognize different pathogens. It can attack and often kill pathogens by eating them, releasing substances that harm them or kill cells that become infected to stop the spread. It has no memory without responding in the same way if the body would be attacked by the same pathogen once again, and it can also activate the specific immune system.
If the unspecific immune system are "chronically" weakening does not take much to make someone sick.
To "wake up" the immune system with immunomodulating drugs do more patients with ME / CFS temporarily better - Why?
In several clinical studies, the majority of patients with ME / CFS treated with antiviral medications felt better, regardless of which drug to use - mainly Valtrex and Valcyte, but also Nexavir and later 4ME. Even "Gottfries stafylokockvaccin" seems to have had a positive effect, but mainly only during treatment. After completion of treatment, most disease recurrence. In the studies succeeded, it seems to be common to immune enhancement expires at the end of treatment.
Could it be that all the preparations have an immunomodulating effect and thus increases the activity of NK cells, which are found to have low activity in the majority of ME / CFS?
Increased activity of NK cells leads to increased production of interferon gamma, which in turn leads to increased activity of macrophages and thus a stronger innate immune system.
There is much more to do!
In addition to implementing many more samples there are today able to (in Sweden) to try some established forms of treatment that has proved successful for ME / CFS patients and even fibromyalgia patients in smaller studies, which are used in other medical cases. Not least when it comes to different forms of oxygen therapy.
The majority of ME / CFS patients have a lack of oxygen at the cellular level, I can not prove it when the blood seems to have normal oxygenation of the majority. It is not only reasonable but logical that the body's cells do not receive the amount of oxygen required. Many patients suffer light of lactic acid. If oxygenation works well as lactic acid should disappear relatively quickly. It does not in the small survey I have done in my FB group Database ME / CFS. If the lactic acid does not disappear after a short moment of rest it is more about a lack of oxygen for more than a lack of COQ10 example, D-ribose, NADH, SAMe and other matters related to the citric acid cycle to do.
There are som who do not get the lactic acid as easy, but (like the others) have a fatigue feeling in the body and in the brain. Oxygen can probably do wonders with them also.
I mention a few examples of treatments that I believe can work very well in both patients with ME / CFS and fibromyalgia. It has to do with oxygenation. Most people know that altitude training is good for increasing oxygenation. To affect the ability to produce more red blood.. That repeated treatments with Hyperbaric oxygen therapy (HBO) stimulates vascular formation and also can be provided in other conditions with poor micro-circulation and / or infection, may not everyone know. Oxygen strengthens the immune system!
1. Eporatio (EPO) treatment
In a study of 60 CFS patients treated with the low dose EPO (8,000 units). Even after 15 days of treatment was 51 pc (85%) of 60 patients improved - with reduced symptoms.
EPO is a drug for anemia.
There are three main types of anemia
1. As a result of blood loss
2. As a result of reduced production of red blood cells
3. Due to increased destruction of red blood cells.
If you specifically looking at p.1 and scroll up a bit on this page so can all see a connection. Many people with ME / CFS have as little blood in the body as one who needs a blood transfusion after a car accident! It has also found a strong correlation between increased lactate level in the brains of ME/CFS patients compared with healthy control group.
Source (p. 13 of the PDF)
2. Oxygen Chamber / High-pressure chamber (HBO)
A clinical trial with 48 women diagnosed with fibromyalgia, showed that the state improved in each of those who completed a two-month oxygen therapy - by staying in the oxygen chamber.
Source
https://newsaboutdisease.wordpress.com/2016/01/06/till-forskare-och-behandlande-lakare-om-mecfs/
2016-01-06
Mats Lindström
Relative