23andme test results, need guidance

[Valentijn]

SUOX helps to detoxify sulfides. There is no ++ status for SUOX because this kind of mutation can be very serious. This means that a heterozygous mutation really needs support.

I can't find any research indicating that rs705703 causes any problems. Could you please cite to your source?

 

[TheChosenOne]

There isn't. But there seem to be a lot of people that report problems.
http://forum2.aimoo.com/OMGthread2/Scientificness/SUOX-and-Sulfite-Toxicity-2-333666.html

 

[kjellfh]

Does anyone know if Sam-e is effective for histamine reduction?

Any other suggestions on how to reduce or block histamine is very welcome. I have tried various "natural" antihistamines such as grape seed extract(GSE), vitamin C, nettle, parsley and quercetin but failed to achieve satisfactory and consistent effects. Feel like this is one my few clues now because H1 antagonists is the only thing that curbs these crippling nightly symptoms a little.

 

[Gondwanaland]

grape seed extract(GSE), vitamin C, nettle, parsley and quercetin

If those supps don't work for you, take a look at oxalates
http://www.lowoxalate.info/
https://groups.yahoo.com/neo/groups/Trying_Low_Oxalates/info

 

[kjellfh]

Hmm.. interesting... I have never had kidney stones or pain when urinating though. I do not eat foods high in oxalates either but I can try lower intake even more anyway. Thanks.

 

[Gondwanaland]

If your diet is already low, don't bother then. The problem must be only amines as you said after all.

 

[ahmo]

I had excellent results with rutin, acts within 15 minutes if I'm in the midst of histamine response. Vit C + Calcium help mobilize histamines, I use them in footbaths. Royal jelly and mangosteen seem to be more closely related to mast cells than directly histamines, though I'm not certain. I wrote a blog post re FMN form of B2. I has made an almost miraculous difference in my need for antihistamines and mast cell stabilizers. There seems to be a connection between MAO and FMN, there are a few links to discussion of this in the blog post. good luck.

 

[kjellfh]

I had excellent results with rutin, acts within 15 minutes if I'm in the midst of histamine response. Vit C + Calcium help mobilize histamines, I use them in footbaths. Royal jelly and mangosteen seem to be more closely related to mast cells than directly histamines, though I'm not certain. I wrote a blog post re FMN form of B2. I has made an almost miraculous difference in my need for antihistamines and mast cell stabilizers. There seems to be a connection between MAO and FMN, there are a few links to discussion of this in the blog post. good luck.

I will check this out. Thank you for your input.

 

[ahmo]

I didn't review the first page of this thread, so maybe it's already been up for discussion, re mast cell issues. I'm giving you a few links. TheThe one entitle canary is a really excellent summarisation of mast cell disorders, an excellent place to begin. There's a mast cell forum on pr, but have a look at the site and see if it's possible that's what's happening for you. Huge range of symptoms. It turns out that mine have been very well defined, and relatively benign, came to serve as barometers for me. (primarily ulcer-like lesions in nostrils, ears, blood blisters in mouth, and my brain. I haven't used any of my supps for nearly a week since starting FMN; remarkable!)

Re HPU test, last link (pyroluria), again I didn't review pg one. May be totally inappropriate. Easily resolved w/ Vit p5p and minerals. Hope this is not TMI. Once I got into histamines, I felt I had to add some mast cell info.

http://www.histamine-intolerance.info/
The Many Faces of Histamine Intolerance http://healthypixels.com/?p=1044

http://thelowhistaminechef.com/wondering-why-you-react-to-everything-you-eat/
http://selfhacked.com/2014/08/01/deal-histamine/

http://thelowhistaminechef.com/these-probiotic-strains-lower-histamine-rather-than-raising-it/
Video talk, incl. supps for histamine http://thelowhistaminechef.com/dr-janice-joneja-histamine-intolerance-interview-pt2/

[url]http://www.histaminintoleranz.ch/download/SIGHI-FoodCompatibilityList_HIT%28EN%29.pdf[/URL]


https://mastcellblog.wordpress.com/2013/11/12/canary/
http://mastcellaware.com/whatisthis.html
http://mastcellaware.com/whatisthis.html
‪

‘Brain Allergy’ and ASD - T. Theoharides, MD, PhD‬https://www.youtube.com/watch?feature=player_detailpage&v=9QbZp3WcC1Q

Neuroprotek http://www.youtube.com/watch?feature=player_detailpage&v=pNQsK9PQL3c

Mastocytosis with Theoharis C. Theoharides, MS, PhD, MD, FAA‬http://www.youtube.com/watch?feature=player_detailpage&v=CplxXGpFeKQ


http://www.hputest.nl/evraag.htm Online questionnaire to suspect pyroluria

 

[kjellfh]

I didn't review the first page of this thread, so maybe it's already been up for discussion, re mast cell issues. I'm giving you a few links. TheThe one entitle canary is a really excellent summarisation of mast cell disorders, an excellent place to begin. There's a mast cell forum on pr, but have a look at the site and see if it's possible that's what's happening for you. Huge range of symptoms. It turns out that mine have been very well defined, and relatively benign, came to serve as barometers for me. (primarily ulcer-like lesions in nostrils, ears, blood blisters in mouth, and my brain. I haven't used any of my supps for nearly a week since starting FMN; remarkable!)

Re HPU test, last link (pyroluria), again I didn't review pg one. May be totally inappropriate. Easily resolved w/ Vit p5p and minerals. Hope this is not TMI. Once I got into histamines, I felt I had to add some mast cell info.

http://www.histamine-intolerance.info/
The Many Faces of Histamine Intolerance http://healthypixels.com/?p=1044

http://thelowhistaminechef.com/wondering-why-you-react-to-everything-you-eat/
http://selfhacked.com/2014/08/01/deal-histamine/

http://thelowhistaminechef.com/these-probiotic-strains-lower-histamine-rather-than-raising-it/
Video talk, incl. supps for histamine http://thelowhistaminechef.com/dr-janice-joneja-histamine-intolerance-interview-pt2/

http://www.histaminintoleranz.ch/download/SIGHI-FoodCompatibilityList_HIT(EN).pdf


https://mastcellblog.wordpress.com/2013/11/12/canary/
http://mastcellaware.com/whatisthis.html
‪

‘Brain Allergy’ and ASD - T. Theoharides, MD, PhD‬https://www.youtube.com/watch?feature=player_detailpage&v=9QbZp3WcC1Q

Neuroprotek http://www.youtube.com/watch?feature=player_detailpage&v=pNQsK9PQL3c

Mastocytosis with Theoharis C. Theoharides, MS, PhD, MD, FAA‬http://www.youtube.com/watch?feature=player_detailpage&v=CplxXGpFeKQ


http://www.hputest.nl/evraag.htm Online questionnaire to suspect pyroluria

Thank you for all the links ahmo, I have not managed to look at all of it yet but I will.
I have ordered rutin, and FMN. I will give them a try before giving up supplements for good.

 

[kjellfh]

Got no relief from FMN/coenzymated B-2, rutin or Mangosteen, tried various dosages at different times, isolated and together.

Started taking cetirizine again to the point that it don`t work anymore. At the beginning, some/great relief from 10mg. Now I dont get any relief from even 50 mg. Seems like tolerance build up rapidly over only a couple of nights. Also tried some Loratadine but got absolutely no effect from this med.

Been reading some of the links and watched some videos.
I just cant figure out the connection to H1 receptors other than that I have used the first generation antihistamine Hydroxyzine(Vistaril/Atarax) extensively in the past. This was for far less severe insomnia problems. Could it be some permanently deregulated histamine receptors? I was on Mirtazapine last year for around 6-7 months, maybe I still suffer some withdrawal from this??

So without any way to lower symptoms that seemingly are getting worse(rebound from newly antihistamine use?)
I am even more desperate. The same type of hot flashes even come sometimes during the morning/day now.

Body temperature is normal(measured orally numerous times) but skin feels extremely hot and I`am sweating in addition to headache, palpitations and a generally feeling of restlessness/anxiousness. If I manage to get to sleep when its going on I feel like a total disaster when I wake up. I generally feel better with no sleep at all than after sleep with these hot flashes.

Also have periods I urinate and feel thirsty all the time but I don't know if this is related or a completely separate condition.

Last weeks I have slept in average 2-4 hours but feel absolutely horrible anyway.
I have managed to get one night with some restful sleep lately after being constantly awake for over 50 hours. The next night however was back to normal/awful. I

One thing that helps me a little is cold baths/showers, but this is very unpleasant and the "effect" is short lived.

My doctor has been very helpful and I think he have checked everything, he says all is fine.

Thyroid, cortisol(blood, urine and saliva), testosterone, other hormones, diabetes, liver, kidney, brain MRI, spinal tap, sleep apnea, HIV, hepatitis and borrelia -tests, ALL HAVE BEEN FINE.

If interested, most of my tests results can be found here.

I have been off work for almost a year now and have had the time to focus all remnants of energy to getting well. Despite doing most of "the right things" I still feel like the opposite is happening and that I am in an accelerated state of degeneration.

For the last year I have(on better days) been doing long walks and yoga(five rites). Also the last months I have been doing a lot of mindfulness and some CBT, this generally helps a lot but not so much on the worst days and nothing at all to the physical symptoms.

I have been taking a strong SSRI for a time now, I dont think I would have managed any longer without.

Going to see a psychiatrist thursday next week after waiting a half year.

Considering to take a histamine blood test, is this any point?

Sorry for all the whining but felt like I needed to write down some of this. I hope to use it for future reference.

I am very grateful for all input until now and any new suggestions are also greatly appreciated.

 

[nandixon]

The only thing that temporarily seems to help me a little these days are antihistamine drugs. Therefore I speculate in that excess histamine is causing some of my problems. Whats weird is that I have little of the "standard" high histamine/allergy symptoms like itching, runny eyes/nose, hives etc. The symptoms I experience that are histamine like are at night - very hot skin/sweating, headache, palpitations, restlessness, cravings and congested nose. After these nights I feel absolutely like garbage and cannot manage to do much other than emptying my fridge and shelves for food.

Any input is greatly appreciated!

@kjellfh, Have you tried using an H2 antihistamine? Sometimes an H1 antihistamine, which you've mentioned you've tried, needs to be combined with an H2 antihistamine to get relief from histamine problems.

I've been having good luck with cimetidine (Tagamet), with or without an H1 antihistamine. I'm not sure where you're located, but cimetidine is available OTC in the U.S. as 200mg tablets.

Cimetidine is a particularly interesting H2 blocker, because while it's normally used to decrease stomach acid, it also seems to have a special immunomodulatory ability, so it might be worth trying over ranitidine (Zantac) or femotidine (Pepcid), for example. (See also this post/thread.)

Cimetidine is a pretty weak acid reducer (e.g., 200mg only reduces stomach acid by about 1/3, if I remember correctly), especially compared to the proton pump inhibitors, and even compared to other H2 blockers, but it may be a good idea to initially just take it at night. (I usually use 50mg at night a couple hours after dinner, and then another 50mg about an hour after breakfast, i.e., spreading the doses about 12 hours apart and attempting to avoid interfering with digestion to the greatest extent possible.)

Also be aware that cimetidine can increase the blood levels of a number of different drugs, including some of the H1 antihistamines like hydroxyzine and diphenhydramine. So depending on how much cimetidine a person takes, they may need to reduce the amounts of other drugs they're taking to compensate for this. (This "problem" can be an advantage when the other drug is expensive.) I can't remember if cimetidine may decrease the concentrations of any drugs.

Good luck!

 

[kjellfh]

Tried everything. The same insomnia still persists. A new observation though: SSRIs(tried numerous and the same every time) including Lithium removes the heat at night after some time on them but the insomnia persists. I beleive the insomnia/heat stuff that happens at night is the cause of most of my other symptoms. Any help?

 

[Gondwanaland]

In the past few days I went inadvertently too low in oxalates and could not sleep anymore. Yesterday I realized it (the red flag was a burning sensation in the kidneys that wouldn't let me stand up for more than 30 seconds) and added high oxalate foods to my dinner + a mozzarella ball (wasn't eating enough calcium either). Ta da! No supplements used.

 

[kjellfh]

All blood tests looks fine now. Only weird thing is very often high/out of range folate. Last test was 28.7 (ref. 7.7-25.0), but I eat a lot of veggies so may be because of that....

 

[Gondwanaland]

All blood tests looks fine now. Only weird thing is very often high/out of range folate. Last test was 28.7 (ref. 7.7-25.0), but I eat a lot of veggies so may be because of that....

How about B12 homocysteine RBC & WBC counts? I think that your folate result must be seen in a larger context.

 

[kjellfh]

How about B12 homocysteine RBC & WBC counts? I think that your folate result must be seen in a larger context.

Yes. RBC (red blood cell count?) I dont find this on my papers, but Hemoglobin is fine (15.3 ref. 13.4-17.0) isn`t this sort of the same thing? I dont have any new homocysteine test but these have been slight high in the past.

 

[Gondwanaland]

RBC (red blood cell count?) I dont find this on my papers, but Hemoglobin is fine (15.3 ref. 13.4-17.0)

My Hemoglobin is in range as well, but Erythrocytes (RBCs) and Hematocrit are low.

 

[kjellfh]

My Hemoglobin is in range as well, but Erythrocytes (RBCs) and Hematocrit are low.

Thank you so much for input Gondwanaland, I cant find none of these on the last blood test, will go through the papers again but I vaguely remember hematocrit is ok.

 

[kjellfh]

Tried Hesperidin and Copper. No help. I am done with supplements I think.

Without H1 antagonists I am a total wreck. Tolerance build up fast though. Tried going off all meds. for longer periods but the nightly symptoms not getting better at all over time and suicidal thoughts comes fast.

When off meds. the symptoms starts around 2300-0000 every night and can last all night. First skin getting warmer and warmer and then palpitations and usually headache after some time. It's impossible to sleep when this is going on.

Currently cycling clemastine, quetiapine and/or trimipramine.

SSRIs and moclobemide remove or lessens the symptoms but cannot sleep at all on them and they creates other problems/side effects. No mood difference on them as with TCAs and Mirtazapine/mianserine.

All blood tests have been fine lately.
Body temp. normal.
Cold and total dark room, fan at the bed.
Diet is good.
Ruled out food sensitivities.
No anxiety/worrying.
Blood sugar is normal.
Cold baths(7-10 C) for 5-10 min remove the symptoms for approx. 2 hours.
30-120 min. light physical activities every day.

Doctors can't find anything wrong.

I don't know what to do.