@
stevesayshi
I did some experiments a while ago, taking a whole set of Th17 inhibitor supplements to see what effect this would have. In my case, I saw no benefits after a week on this regimen, and I also found I became more irritable as a result of the regimen, so I stopped it. However, it may certainly be worth trying some anti-Th17 supplements.
In case it is of use for you, here is the list of anti-Th17 drugs and supplements I compiled:
Anti-Th17 Drugs and Supplements
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Spironolactone blocks the action of aldosterone, and aldosterone promotes Th17 polarization.
1
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Green tea extract EGCG inhibits the differentiation of Th17 cells.
1
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N-acetylglucosamine inhibits Th1 and Th17 responses.
1
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Methylprednisolone has a suppressive effect on Th17 cells.
1
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Simvastatin inhibits IL-17 and Th17.
1
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Galactoxylomannan, a polysaccharide from opportunistic fungus Cryptococcus neoformans, inhibits IL-17A and Th17.
1
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Interferon alpha down-regulates IL-17 expression and Th17 differentiation in vitro and in vivo.
1
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Interferon beta inhibits human Th17.
1
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Etanercept downregulates the Th17 pathway.
1
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Propolis inhibits the differentiation of Th17 cells.
1
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Ursolic acid blocks stat3, and the inhibition of Stat3 activation blocks Th17 activation while promoting Th1 or cell mediated immune responses.
1 • Ursolic acid can be obtained as the supplement: Ursobolic made by E-Pharm.
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Zinc suppresses Th17 development via inhibition of STAT3 activation.
1
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Digoxin (from foxglove, Digitalis lanata) and its derivatives suppress Th17 cell differentiation.
1
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Telmisartan inhibits Th17 differentiation.
1
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Valsartan. Th17 cells increased by angiotensin II, so angiotensin II inhibitors like valsartan might reduce Th17.
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Vitamin D suppresses Th17 cytokine production.
1
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Vitamin D plus a
TNF inhibitor will reduce Th17.
1
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Vitamins A and D synergistically Suppress the Development of Th17 Cells.
1 2
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Retinoic acid inhibits Th17.
1 Beta carotene a precursor of retinoic acid.
1
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Calcipotriol (vitamin D analogue) suppresses Th17.
1
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Baicalin inhibited Th17 cell differentiation.
1
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Grape seed extract reduces Th17 / Treg ratio.
1
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Triptolide, from the herb Tripterygium wilfordii, inhibits the differentiation of Th17 cells.
1
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Cordyceps sinensis increases regulatory T cells to Th17 cell ratio.
1
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Fucoxanthin (found in brown seaweed) induces regulatory T cells and inhibits Th17 cell differentiation in vitro.
1 Fucoxanthin can be bought as a supplement.
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Berberine suppresses Th17 and Th1 T cell differentiation in type 1 diabetic mice.
1
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IDO (indoleamine-2-3-dioxygenase) activates T regs and blocks Th17 cells. Tryptophan inhibits IDO.
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Restricting proline reduces Th17 cell differentiation.
Foods highest in Proline
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Intermittent fasting might be helpful - it increases the amino acid starvation response (= amino acid response pathway, AAR), which then reduces Th17.
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Segmented filamentous bacteria (Candidatus Savagella) in the gut
increase Th17 cells.
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Olive leaf extract reduces IL-17 (and presumably therefore Th17).
1
Note: blocking IL-6 inhibits Th17 (so IL-6 blockers like
luteolin might inhibit Th17). Chocolate boosts IL-6.
Note: psoriasis is a Th17 mediated skin disease.
Note: The complement system drives Th17 cell differentiation and triggers autoimmune arthritis.
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Note: Candida albicans is a potent inducer of the Th17 response.
1
