mitochondria

In 2022 Wirth and Scheibenbogen showed a ~20% increased sodium muscle content in ME/CFS patients: https://refubium.fu-berlin.de/handle/fub188/43366 Why is the sodium overload important? Because according to their hypothesis it is the sodium overload which causes a calcium overload which causes...

Increased levels of d lactic acid and acute episodes of d lactic acidosis have been linked to ME/CFS. Acute episodes of d lactic acidosis typically last hours to days. Symptoms can include confusion, inability to concentrate, fatigue, hallucination, clumsiness, weakness, impaired muscle...

I often see ME/CFS patients that undergo exercise tests to be diagnosed with two problems: orthostatic intolerance (preload failure) and impaired oxygen extraction (mitochondrial dysfunction). They seem to be pretty well connected, but I've never seen anyone explaining which one is driving the...

Really interesting simplifying presentation about the Krebs and energy cycle by the Royal Institute. Goes over the history of the finding for mitochondria and some of the simplified chemistry and variants of cycle.

I'm due to start Acyclovir and from researching it seems most antivirals cause some degree of Mitochondrial Toxicity. Is there a way to avoid or negate these toxicity side effects? From this table there's a host of effects from Acyclovir: Source...

It is winter here, and on sunny days, when the midday sun streams across the carpet, I have been lying on cushions with the back of my head bathed by the sun. why? Sunlight is rich in red and infrared light preliminary research suggests these longer wavelengths of light support mitochondrial...

Does anyone have any advice that if CoQ10 improves symptoms, then what else might also work, given CoQ10's actions in the cell and ME pathophysiology? If I take 1400 mg ubiquinol it takes a couple of hours to start working, but it pretty consistently helps with some of the worst ME symptoms for...

I thought this 2020 meta-analysis from Staines and Marshall-Gradisnik had already been posted, but I must have missed it... A systematic review of mitochondrial abnormalities in ME/CFS/SEID (Holden et al., 2020) https://dx.doi.org/10.1186%2Fs12967-020-02452-3 Excerpt:

From the team of Warren Tate who, I am obligated to say, comes from New Zealand: Role of mitochondria, oxidative stress & the response to antioxidants in ME/CFS: A possible approach to SARS-CoV-2 ‘long-haulers’? (Wood et al., 2021)...

Another literature review from Staines and Marshall-Gradisnik: A systematic review of nutraceutical interventions for mitochondrial dysfunctions in ME/CFS (Maksoud et al., 2021) https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-021-02742-4 Excerpt:

https://www.mdpi.com/1422-0067/22/4/2046

A very very promising peptide under the name SS-31 (licensed name will be elamipretide) This peptide seems to have grabbed the attention of scientists researching a healing for mitochondrial myopathies. Ron Davis mentioned this as one possibly working peptide to help CFS patients! Randomized...

An Isolated Complex V Inefficiency and Dysregulated Mitochondrial Function in Immortalized Lymphocytes from ME/CFS Patients Daniel Missailidis , Sarah Annesley , Claire Allan , Oana Sanislav , Brett Lidbury , Don Lewis , Paul Fisher * Version 1 : Received: 3 September 2019 / Approved: 4...

Asking everyones views , is ketogenic diet good for mitochondria function in general, better even than any so called normal diet which have more carbs ? I just semi-randomly read again about feeding mitochondrias, and this caught my eye : "One of its leading advocates is neurologist Jong Rho...

This 2019 study is free to access. Mitochondrial Dysfunction in Skeletal Muscle of a Fibromyalgia Model: The Potential Benefits of Melatonin ( https://www.mdpi.com/1422-0067/20/3/765 ) Discussion points of study - melatonin is: "useful to improve mitochondrial performance" "antioxidative"...

I hope this isn't another duplication, but I can't find any threads in the latest ME/CFS research threads featuring the names of these researchers: Could mitochondrial dysfunction be a differentiating marker between Chronic Fatigue Syndrome and Fibromyalgia? Castro-Marrero J, Cordero MD...