• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of, and finding treatments for, complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia, long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

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  1. SWAlexander

    SARS-CoV-2 infection is associated with intestinal permeability, systemic inflammation, and microbial dysbiosis in hospitalized COVID-19 patients

    Abstract Coronavirus disease 2019 (COVID-19) and associated severity has been linked to uncontrolled inflammation and may be associated with changes in the microbiome of mucosal sites including the gastrointestinal tract and oral cavity. These sites play an important role in host-microbe...
  2. Celandine

    Guardian article on the Remission Biome Project--gut and antibiotic exploration for ME/CFS

    https://www.theguardian.com/science/2023/jul/09/microbiome-chronic-fatigue-me-long-covid-research I've been following this on Twitter for a while. Nice to see it get some mainstream attention. Self-experimentation at its finest!
  3. C

    Microbial Composition and Stool Short Chain Fatty Acid Levels in Fibromyalgia (Kim, Kim, Kang, 2023)

    Abstract Background: The present study aimed to evaluate microbial diversity, taxonomic profiles, and fecal short chain fatty acid (SCFA) in female patients with fibromyalgia syndrome (FMS). Methods: Forty participants (19 patients with FMS and 21 controls) were included in the study, and the...
  4. C

    Phd thesis: Investigating Immune Reactivity to the Intestinal Microbiome in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Seton, 2022)

    Abstract Introduction: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) pathogenesis is thought to be multisystemic, including the immune and gastrointestinal systems. A proportion of patients experience gastrointestinal disturbances with evidence suggesting a leaky gut. It was...
  5. SWAlexander

    Studies find that microbiome changes may be a signature for ME/CFS

    Researchers have found differences in the gut microbiomes of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) compared to healthy controls. Findings from two studies, published in Cell Host & Microbe and funded by the National Institutes of Health add to growing evidence...
  6. SWAlexander


    The Patient-Led Research Collaborative’s Patient-Led Research Fund announced $4.8 million in biomedical research awards today, funding 9 research projects in Long COVID, ME/CFS, dysautonomia, and associated conditions. This fund and awarded projects are distinctly meaningful for four major...
  7. Phoenix Rising Articles

    Article What It Is To Be Human: Holobionts and the Microbiology of Myalgic Encephalomyelitis

    What It Is To Be Human: Holobionts and the Microbiology of Myalgic Encephalomyelitis Dr. Amy Proal, of the PolyBio Research Foundation, explains how a human body is so much more than just a collection of human cells. Images courtesy of Dr. Amy Proal. By Bronc Dr. Amy Proal, of the PolyBio...
  8. C

    The Role of Kynurenine Pathway and NAD+ Metabolism in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (Dehhaghi et al, 2022)

    Abstract Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious, complex, and highly debilitating long-term illness. People with ME/CFS are typically unable to carry out their routine activities. Key hallmarks of the disease are neurological and gastrointestinal impairments...
  9. godlovesatrier

    [Study] Jan 20 2022 Early life viral infections disturb respiratory microbiota

    Nature.com: Early-life viral infections are associated with disadvantageous immune and microbiota profiles and recurrent respiratory infections. https://www.nature.com/articles/s41564-021-01043-2 @Pyrrhus
  10. C

    The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) (König et al, 2022)

    The Gut Microbiome in Myalgic Encephalomyelitis (ME)/Chronic Fatigue Syndrome (CFS) Authors: Rahel S. König Werner C. Albrich Christian R. Kahlert Lina Samira Bahr Ulrike Löber Pietro Vernazza Carmen Scheibenbogen Sofia K. Forslund Abstract Myalgic encephalomyelitis (ME) or Chronic Fatigue...
  11. C

    Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children (Roslund et al, 2020)

    Abstract As the incidence of immune-mediated diseases has increased rapidly in developed societies, there is an unmet need for novel prophylactic practices to fight against these maladies. This study is the first human intervention trial in which urban environmental biodiversity was manipulated...
  12. nerd

    Bacterial neurotoxic metabolites in multiple sclerosis cerebrospinal fluid and plasma

    Authors: Achilles Ntranos, Hye-Jin Park, Maureen Wentling, Vladimir Tolstikov, Mario Amatruda, Benjamin Inbar, Seunghee Kim-Schulze, Carol Frazier, Judy Button, Michael A Kiebish, Fred Lublin, Keith Edwards, Patrizia Casaccia Published on: December 11, 2021 doi: 10.1093/brain/awab320 Abstract
  13. nerd

    Isolation of pancreatic microbiota from cystic precursors of pancreatic cancer with intracellular growth and DNA damaging properties

    Authors: Asif Halimi, Giorgio Gabarrini, Michał Jacek Sobkowiak, Zeeshan Ateeb, Haleh Davanian, Rogier Aäron Gaiser, Urban Arnelo, Roberto Valente, Alicia Y.W. Wong, Carlos Fernández Moro, Marco Del Chiaro, Volkan Özenci & Margaret Sällberg Chen Published online: November 24, 2021 doi...
  14. SWAlexander

    Multi-omics of host-microbiome interactions in short- and long-term Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)

    Abstract Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system, debilitating disability manifesting as severe fatigue and post-exertional malaise. The chronic dysfunctions in ME/CFS are increasingly recognized as significant health factors with potential...
  15. H

    Causes of MCAS?

    Hi all, I'm wondering if anyone has any info on what are the possible causes of MCAS? And if someone's looking to try to address the root cause of their MCAS what areas should they look into, and in what order of importance? I'm also interested in whether anyone here has managed to figure out...
  16. Jwarrior77

    The Causes of ME/CFS, POTS, and Chronic Illness - A patients opinion

    This is my opinion on the causes of these illnesses coming from a patient who suffers from these conditions. My opinion is based on my own experience, research from the top scientists studying this, and also other patients such as Jeff Wood, Jen Brea, and others who have contributed a lot of...
  17. Kes

    There's no place like Microbiome -(Probiotic advice please)

    Howdy 🤠 folks, I've not ventured really into the probiotic world other than an unsuccessful experiment with kefir a few years ago which made me feel rough,more fatigued basically. I'd be nervous about starting out with anything too strong. I am severely affected and am only managing to be out...
  18. PatJ

    Study finds hemorrhagic brain disease caused by gut bacteria metabolite

    I'm not sure if this has been posted before. Considering how gut bacteria might be connected with ME/CFS I thought some of our members might be interested in this article on NewAtlas: Study finds hemorrhagic brain disease caused by gut bacteria metabolite. Some excerpts:
  19. M

    Help! Develop rashes when eating but all food sensitivities negative. Gut issues?

    I have been sick for a little over a year now and just a few months ago I started having reactions occasionally when eating. The reaction starts by causing my ears to get really red and hot, then my face, chest, shoulders, elbows, knees (basically all joints) becomes really red and hot. After...
  20. MaximilianKohler

    Who to contact to get an FMT clinical trial with high quality donors?

    There is tremendous support for FMT being close to a panacea with the major caveat being that the donor is in perfect health, with an unperturbed, disease-resistant, curative gut microbiome. It's currently looking like fewer than 0.4% of the population qualifies: I've done DIY FMTs from 9...