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Loss of IgG

Discussion in 'Immunological' started by paolo, Nov 22, 2013.

  1. paolo

    paolo Senior Member

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    Italy
    Hi everyone,

    I've lost the IgG of EBV, which infected me 12 years ago, starting my M.E. My immunologist said she have never seen a person who had lost IgG.

    Have some of you lost IgG of EBV or of any other virus/bacteria?

    I don't have IgG for any other virus/bacteria.
     
  2. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    australia (brisbane)
    I also have lost my igg antibodies to ebv. Apparently its quite common amongst cfs/me and i first read about it in oslers web when cheney and peterson had patients who stopped producing igg antibodies. So much for igg be antibodies forever??

    Im unsure what it means, its possible that these dam viruses are running around doing what they like and the immune system is allowing it??

    cheers!!
     
    Nielk likes this.
  3. Valentijn

    Valentijn Senior Member

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    I got tested for Herpes Simplex 1/2 and was negative for IgG, even though I'm pretty sure I had it when I was 6 or so. Myself and everyone else at daycare came down with "cold sores" for a while. I also tested negative for EBV, even though almost everyone has that one.

    The lab initially reported that I tested positive to toxoplasmosis IgM, but negative to IgG. They later changed that to say that both were negative, so who knows.
     
  4. SOC

    SOC Senior Member

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    Makes ya wonder, doesn't it? Sounds like some dry-labbing to me -- "Oh, she can't have IgM, but no IgG so the data must be wrong. I'll just change it so it looks right...." :rolleyes:
     
    Sea and Valentijn like this.
  5. SOC

    SOC Senior Member

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    @paolo
    @heapsreal

    Have you guys ever had your immunoglobulins tested to see if you have hypogammaglobulinemia? Might that explain disappearing EBV IgG antibodies?
     
  6. heapsreal

    heapsreal iherb 10% discount code OPA989,

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    mostly high, igg immunoglobulins were just above normal and iga always high, getting new results soon on all those.
     
    SOC likes this.
  7. paolo

    paolo Senior Member

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    Hi, I don't have Hypogammaglobulinemia, even if I've lost IGG for EBV.
     
    SOC likes this.
  8. Rlman

    Rlman Senior Member

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    My EBV and CMV are negative for IGG/IGM as well but I am positive IGG for toxoplasmosis. Rubella antibodies also detected.
     
  9. Rlman

    Rlman Senior Member

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    Toronto, Canada
    @heapsreal, are you positive IGG for other infections or IGG negative for everything like paolo?
     
  10. halcyon

    halcyon Senior Member

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    Could it have been herpangina?
     
  11. JalapenoLuv

    JalapenoLuv

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    unknown
    Yes this happened to me as well. When I was initially infected with EBV in 2008 I was positive for IgG initially but all subsequent testing was negative. I think it is because the infection blocks antibody formation by disabling macrophages so the IgG stops being produced.
     
  12. Hip

    Hip Senior Member

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    There is an interesting article about the disappearance of EBV IgG antibodies here. The article says that:
     
    Helen likes this.

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