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Evidence of widespread metabolite abnormalities in me/cfs-whole-brain magnetic resonance spectrosco

Discussion in 'Latest ME/CFS Research' started by Hufsamor, Jan 9, 2019.

  1. andyguitar

    andyguitar Senior Member

    South east England
    Thanks for posting that @Hufsamor. Cant say I am suprised by the research findings. Dont despair @perrier. Identifying a problem is the only way to a solution. First steps. Its been a long,long road.
    Pyrrhus, MonkeyMan, Hufsamor and 2 others like this.
  2. Sad Dad

    Sad Dad

    Please don't despair. I haven't read the published paper yet, but in Dr. Younger's presentation, he said he was working to find a drug to treat this and thought Naltrexone might be close.

    I'm very impressed with Dr. Younger. Not only is he doing great research, but like Dr. Davis, he is sharing it before it is published. Finally, he is looking for clinical solutions.
    Webdog, andyguitar, MonkeyMan and 3 others like this.
  3. jesse's mom

    jesse's mom Moderator

    Alabama USA
    Yes! and he is communicating with other researchers! I like him so much!
    Pyrrhus, merylg, andyguitar and 3 others like this.
  4. ljimbo423

    ljimbo423 Senior Member

    United States, New Hampshire
    At the end of this video (it's only 21 minutes long), from last Septembers OMF symposium. At 18:35, Jarred Younger says that he just got a grant from the ME Research UK group.

    To see if T cells and B cells are crossing the Blood Brain Barrier (BBB) and causing the brain inflammation in ME/CFS.

    He said he should have the results hopefully, within a year. That would be by this September.

    He says "if we can find these cells in the brain, it's going to be really, really important to understanding the pathology of ME/CFS."

    Last edited: Jan 10, 2019
    Pyrrhus, MonkeyMan, Murph and 5 others like this.
  5. Murph

    Murph :)

    Great work here by Jared Younger and his team. He is rapidly ascending the ranks and he might be at this moment the researcher with the best flow of findings.

    If I could summarise this paper I'd say they went looking for chemicals in the brain that might be evidence of neuroinflammation. They found plenty. They were able to specify the locations of various of these chemicals in different brain regions.

    Looks like Choline was the most prominent, in the left anterior cingulate region.

    Screen Shot 2019-01-11 at 10.09.47 AM.png

    The most significant difference in the study was CHO in the left ACC. We note this area in particular because it is the only region to survive corrections for multiple comparisons, and because it has been noted as a critically important region mediating cytokine-induced fatigue and mood deterioration (Capuron et al. 2005; Harrison et al. 2009). Cytokineinduced fatigue and depressive symptoms have previously been attributed to inflammation in the ACC, as indicated by elevated glutamate on MRS (Haroon et al. 2014). The current study provides further evidence for the link between ACC inflammation and fatigue by demonstrating that ME/CFS patients show elevated CHO in this region.

    The wikipedia on this part of the brain mentions autonomic functions which got me excited but mostly focuses on error detection and morality. It's hard to say if those are just things psychologists like to test or if those are really the core functions of this part of the brain. I don't feel we are especially morally deficient! Probably neuroscience is not yet really advanced enough to find regions of the brain that have very specific functions.

    It's worth mentioning that in this study the observations are "normalised" by comparing to creatine levels. This looks to be standard practice but I can see an argument that creatine - an amino acid - could vary in patients. I hope Younger has a plan to rule out that as a potential source of bias.
    cigana, anni66, MonkeyMan and 3 others like this.
  6. Belbyr

    Belbyr Senior Member

    The future B and T cell work could be huge.

    I wish I were well enough to participate, I'm only 2.5 hours from Jared. :bang-head:
    Hufsamor and ljimbo423 like this.

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