Previous neuroimaging studies have detected markers of neuroinflammation in patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). Magnetic Resonance Spectroscopy (MRS) is suitable for measuring brain metabolites linked to inflammation, but has only been applied to discrete regions of interest in ME/CFS. We extended the MRS analysis of ME/CFS by capturing multi-voxel information across the entire brain. Additionally, we tested whether MRS-derived brain temperature is elevated in ME/CFS patients. Fifteen women with ME/CFS and 15 age- and gender-matched healthy controls completed fatigue and mood symptom questionnaires and whole-brain echo-planar spectroscopic imaging (EPSI). Choline (CHO), myo-inositol (MI), lactate (LAC), and N-acetylaspartate (NAA) were quantified in 47 regions, expressed as ratios over creatine (CR), and compared between ME/CFS patients and controls using independent-samples t-tests. Brain temperature was similarly tested between groups. Significant between-group differences were detected in several regions, most notably elevated CHO/CR in the left anterior cingulate (p < 0.001). Metabolite ratios in seven regions were correlated with fatigue (p < 0.05). ME/CFS patients had increased temperature in the right insula, putamen, frontal cortex, thalamus, and the cerebellum (all p < 0.05), which was not attributable to increased body temperature or differences in cerebral perfusion. Brain temperature increases converged with elevated LAC/CR in the right insula, right thalamus, and cerebellum (all p < 0.05). We report metabolite and temperature abnormalities in ME/CFS patients in widely distributed regions. Our findings may indicate that ME/CFS involves neuroinflammation.
As I said in my last post, this is Jarred Younger's work. If I remember right, he said this year he would be looking for immune cells (T cells and B cells ) that might be crossing the Blood Brain Barrier and causing the brain inflammation he has found.
If he can find them (T cells and/or B cells), maybe he can trace them back to where they came from, finding the root cause of the immune system activation and possibly the primary cause of ME/CFS.
I did an application for whatever he has upcoming, there was mention I would need to be there for twice weekly blood draws for three months. I am willing to go up and get the draw, then stay over in Birmingham get another one, then drive home.
Perhaps then I could get in the next brain MRI study... If I could be a part of even trying for a cure I will do whatever I can.
Oh, but it must not get you down
Every study points towards what's wrong, then it might be fixed!
Like if you're having a leak in your house
and a professional finally figures out where it comes from.
Next step: the fix....
Hang in there!