I have dealt with OCD, anxiety and depression my whole life and tried many different antidepressants. A year ago I got off the meds because I was experiencing extreme fatigue to the point that I was falling asleep at stoplights. They also didn’t seem to be working well and I had tried many different meds prescribed by many different doctors over many different years. I have also tried therapy for the last ten years and tried different therapists Once I decided to get off the meds, I proceeded to see a ton of drs all year long and had lots of expensive/extensive bloodwork done. They all had different ideas (most contradicting each other). I can send the 30 plus pages of bloodwork to anyone who wants to take a look. I had low T (total – not free, low vit C, low LDH and aluminum as well as past epsteing barr. At this point I am not feeling too bad other than awful anxiety and depression. I saw a psychiatrist last month who recommended Pristiq and Deplin. I wanted to wait on the Pristiq but have started the Deplin. I didn’t want to start down the med route again. I may have to, but I am scared to and don’t want to end up in the fatigue boat as well as all of the side effects that made me get off them in the first place. In researching the deplin, someone had mentioned the a1298c. That sounded familiar so I looked at my bloodwork and googled. I am positive for 2 copies of the a1298c mutation. I am homozygous for a1298c mutation and negative (normal) for the c677T mutation in the mthfr gene. I just want to make sure that I am not doing anything detrimental and that I am doing the best that I can do. The Deplin is 15mg. I have been taking it for 2 weeks and don’t feel any different. Is this normal? I am making healthy choices to try and fight this as well as therapy which never works for me. The only thing that I am taking is Vitamin D, Cod liver, spirulina and the Deplin. I am occaissonally taking Ativan when I need it. Is it ok that I am taking that Deplin? Will it help me? Should I be taking or NOT taking anything else? Should I get periodic bloodwork to check my liver or anything else? Should I be conscious with anything else because of this mutation? Is there anything else that I should be doing/taking or not taking/avoiding? Is my anxiety related to this at all? Is it ok to take deplin? Can I drink moderately (couple of glasses of wine a week?) My main concerns are that I am doing everything I can do and not doing anything that will cause me harm. I also need to take a break from all this testing/supplementing/focusing on my health. It has been a draining year and I need a bit of a break (mentally and financially) I can’t heal my gut, get off gluten, do chelation and such all at once. I have to break it down into small manageable pieces. One of the things that overwhelms me is that you need to take supplement x. When you do that you need to take these to balance that. You then need to do this and that and check this and that. I want to get off that boat for a while and focus on healthy eating/meditation/cardio/therapy. I do have methylcobalamin injections that a doctor gave me. Should I be taking that? How much/how often? I am always confused by B vitamins in general. Can you take too much? Are they all water soluble and you just pee out any excess? Should I be taking Niacin? Thank you in advance for any help that you can offer me. I apologize for the long msage. Please let me know if you have any questions or need to know any of my levels.