1. Patients launch $1.27 million crowdfunding campaign for ME/CFS gut microbiome study.
    Check out the website, Facebook and Twitter. Join in donate and spread the word!
ME/CFS and Beating the Clock
For Jody Smith, the ticking of a clock was enough at one time to chase her back to her bed. But with the passage of time, she has been able to reclaim her living room ...
Discuss the article on the Forums.

GABA completely unavailable in New Zealand: Any advice on alternatives?

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by josephinegolightly, Dec 17, 2013.

  1. josephinegolightly

    josephinegolightly

    Messages:
    3
    Likes:
    0
    Hi,

    I've spent a lot of time on this forum learning about methylation.

    I live in NZ and have been suffering from ME for 15 years (I am now 32) I have just had my 23andme results come through. and my Australian doctor suggested I try GABA to start the process , which would hopefully enable me to come off my long term medication: Amitriptyline, Gabapentin, Klonopin (only 0.5mg).

    However I have just found out GABA is an banned / illegal drug in NZ (apparently it's just us and Sweden that prohibit it!) So I can't get it.

    Can anyone suggest an alternative, maybe something that might help me raise GABA levels without taking GABA directly.

    One of my problems is I'm MAO-A R297R ++ so I can't really take anything that affects other brain chemicals, seratonin, dopamine etc, as I'm super super sensitive to those changes.

    These are my 23andme mutations (using genetic genie)

    Methylation
    Homozygous:
    MAO-A R297R (Amy Yasko's interpretation)
    MTRR A664A

    Heterozygous:
    COMT V158M
    COMT H62H
    VDR Bsm
    VDR Taq
    ACAT1-02
    MTHFR A1298C
    MTRR A66G
    BHMT-02
    BHMT-04
    BHMT-08


    Thanks in advance!
    Jo
     
  2. Violeta

    Violeta Senior Member

    Messages:
    554
    Likes:
    210
    I read an article a couple of months ago that said that plant oils that contain terps are agonists to the GABA receptors, but I can't find it right now. I don't know if you would have to actually eat peppermint or maybe eat cough drops with eucalyptus oil. I have an Olba's natural inhaler that contains oils of peppermint, cajeput, and eucalyptus. If I can find the article I'll post the link.
     
  3. caledonia

    caledonia

    Messages:
    2,979
    Likes:
    1,577
    Cincinnati, OH, USA
    List from Yasko:
    Maintaining a Healthy Glutamate/GABA Balance
    Branched chain amino acids (use only products that contain leucine/ileucine/ valine—but discontinue immediately if urine smells like maple syrup)
    Pycnogenol
    Grape seed extract
    GABA
    Nerve Calm Inflammatory Pathway Support RNA
    Lithium orotate (depending on levels on urine essential elements test)
    Sublingual GABA/ glycine
    Trehalose
    Valerian root
    Zen

    You could also do theanine, which I did for many years, and it worked well, but I heard something recently about it having some kind of hormonal effect which might not be good.

    It may also be helpful to eliminate MSG and glutamates in foods. Since they're everywhere under hidden names, to keep it simple, I suggest not eating any processed food, sauces or spices, and to avoid the four foods with a lot of natural glutamate - peas, tomatoes, Parmesan cheese, and mushrooms.

    http://www.dramyyasko.com/resources/autism-pathways-to-recovery/chapter-4/
     
    Hanna and helen1 like this.
  4. helen1

    helen1 Senior Member

    Messages:
    339
    Likes:
    235
    B.C., Canada
  5. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,319
    Likes:
    4,672
    australia (brisbane)
    Look into taurine an amino acid that effects gaba. Cant remember the exact details of it though??
     
  6. Hip

    Hip Senior Member

    Messages:
    3,129
    Likes:
    2,978
    If you are looking to normalize the glutamate and GABA balance in the brain, GABA supplements don't really work anyway, as GABA does not cross the blood brain barrier.

    So that makes GABA not only pointless to use as a GABA activator, but also pointless to ban as well, as far as I can see.

    I'd suggest trying to block NMDA receptors (glutamate receptors) rather than activate the GABA receptors, as this will have the same effect on the glutamate — GABA balance. Transdermal magnesium oil is a good NMDA blocker. Taurine is also useful, as heapsreal mentioned, as it works both as a GABA booster and NMDA blocker.
     
    Last edited: Dec 18, 2013
    heapsreal likes this.
  7. Hip

    Hip Senior Member

    Messages:
    3,129
    Likes:
    2,978
  8. Violeta

    Violeta Senior Member

    Messages:
    554
    Likes:
    210

    I know they say taking gaba won't work because it doesn't cross the bbb, but I know someone who took it for depression after her 4th brain surgery, and she said it worked, and very quickly at that.
     
  9. Hip

    Hip Senior Member

    Messages:
    3,129
    Likes:
    2,978
    I bought 300 grams of GABA in bulk powder, and took high doses of it, but it made not one iota of difference to the anxiety symptoms I was suffering with at the time.

    It's possible that GABA may have effects within the body that are beneficial, though.


    Incidentally, one effective way to get GABA into the brain is by taking the supplement picamilon, which consists of a GABA molecule bonded to a niacin molecule. This combination is able to cross the BBB, and once the brain, it breaks down into GABA and niacin.

    As picamilon is a different chemical to GABA, you should be able to buy it New Zealand.

    I found picamilon reasonably effective in treating my anxiety symptoms.

    It says on this webpage that picamilon is a very effective vasodilator (it improves brain blood flow). So that may be generally be useful in ME/CFS, where brain blood flow is poor.


    Note: if you want to try picamilon, I suggest you buy it in bulk power form, as it is much cheaper that way.
     
    Last edited: Dec 19, 2013
  10. Hip

    Hip Senior Member

    Messages:
    3,129
    Likes:
    2,978
    In another thread (in this post) @Ema wrote:
    So if GABA works for you, it indicates you have a leaky or impaired blood-brain barrier.
     
  11. Ema

    Ema Senior Member

    Messages:
    3,422
    Likes:
    3,790
    Midwest USA
  12. Hip

    Hip Senior Member

    Messages:
    3,129
    Likes:
    2,978
    Thanks Ema. I will just copy an extract from that link here:
     
    Last edited: Dec 19, 2013
  13. josephinegolightly

    josephinegolightly

    Messages:
    3
    Likes:
    0
    Thanks so much There are so many great responses here. I'll do some research into all these options over christmas.
    and report back.
    Joanna
     
  14. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    7,319
    Likes:
    4,672
    australia (brisbane)
    The supplement phenibut is gaba with something added to it to cross the blood brain barrier. Its quite strong and very sedating. When i tried it, it felt like it had a delayed reaction as it took along time to work, slept well but then woke up sedated for the whole day, felt like crap. This could have been dose related. I cant remember the exact dose but it may have been 1000mg and after an hour or so no response so took another 1000mg, may have been a third dose before i felt anything but when it hit, it hit. I have read about people being addicted to it or having withdrawal issues etc. So supplement companies selling this generally state to use know more then twice a week or something along those lines??

    Generally to get gaba to work they need to add something to it to help it cross the BBB.
     
  15. PeterPositive

    PeterPositive Senior Member

    Messages:
    548
    Likes:
    215
    Has anyone experimented with L-Glutamine to help with anxiety problems?
    I was given 1000mg for a 4 months period to help healing gut inflammation but I found it would usually trigger anxiety even though I read it's a GABA precursor.

    Then I noticed there's a bit of controversy in terms of studies and supposed effects. Here's an interesting article that doesn't vouch in favor of glutamine:
    http://articles.mercola.com/sites/articles/archive/2004/05/1/glutamine.aspx

    Any comments?

    Thanks
     

See more popular forum discussions.

Share This Page