I really believe I have successfully treated Lyme and co-infections but am now left with a totally out of whack nervous system. My sympathetic nervous system is always turned way up and I simply can't calm down ever. I have lost the ability to relax. I always feel like my insides are going 100 mph even when I am sitting...laying down...etc. I try to keep going so I don't feel so terrible. I never feel sleepy tired but just a deep fatigue which really has an huge impact on my daily life. Also when I am really feeling over stimulated the neuropathy and twitching in my calves also increases tremendously. I am moving to NC in 10 days and of course that has had a huge impact on all this as well. I have tried so many supplements etc..to try and help with the over stimulation feeling but nothing really helps. I finally have my sleep under control for the past year so I can't blame anything on lack of sleep because I now sleep quite well. If I could only find a solution to help with this it would make a huge difference. My doctor did try several things like seraphos...which made me feel drained and exhausted along with some menopause supplements which did the same. Anyone else here have this as a huge problem? It causes so much tiredness all the time.