I'm doing transdermal methylB12 now. I have Vitamin Research Products' liquid that is intended to be used sublingually. Initially I applied it to my upper thighs with Everclear and coconut oil. It would appear to soak in, but later I would see red stains on my pants. I switched to my arms and would sometimes see some red in the crease of my elbow. Then I replace the coconut oil with a drugstore lotion and have not seen any more red. I think I am getting at least as much benefit as I did from the sublingual tablets.