Gondwanaland
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This thread might add some info (or not) to the thread about pyroluria.
A few facts from the top of my head regarding the basic knowledge about vitamin B6 (if anyone knows anything else, please add):
It’s the backbone of Krebs cycle linking protein and carbohydrate/fat metabolism
Image Source
My experience with it:
Taking 60mg of vitamin B6 in a Bcomplex with various dosages of other Bs completely blocked B6 activation in the body (I know because I had symptoms related with the functions mentioned above, for instance alarmingly low serotonin from any tiny increase or decrease in B2 which I kept between 2 and 8mg).
Taking 6mg of P5P daily caused me hyperthyroidism (had to stop my hormone replacement and take lots of Selenium) and serotonin syndrome (unbalance with B2 caused serotonin to build up causing migraine, anorexia/nausea, hypersalivation and rhabdomyolysis) after 10 days.
Cleared a psoriasis-like patch in my neck, helps with dandruff (my dandruff is from histamines?!).
Nice feeling of hands and feet warming up after a meal containing meat, chicken or fish (like the body actually making energy from B12 and iron).
Occasional numbness (esp. arms) even taking tiny doses - taking B12 helps.
My husband gets bacterial symptoms from P5P – cough and furunculosis which subside by increasing arginine in his diet by eating nuts – OR this is oxalate dump which stops by eating more oxalates.
Research on it doesn't seem to consider the blocking effect of large doses of B6/absence of P5P in the supplements on its own metabolism.
( @dannybex perhaps you can gain some insights on your B6 problems?)
This (Linus Pauling Institute) is probably the most extensive review on vitamin B6 online.
B6 interactions with hormones
A few facts from the top of my head regarding the basic knowledge about vitamin B6 (if anyone knows anything else, please add):
It’s the backbone of Krebs cycle linking protein and carbohydrate/fat metabolism
Image Source
- B6+ Fe + Cu = Heme
- B6 = maturation and proliferation of lymphocytes (thus immune modulation)
- B6/Cu + B2/Mg = protein and neurotransmitter synthesis and breakdown (amino acid metabolism- it actually extracts energy from our food) - B6 synthesizes serotonin from Tryptophan, and breaks down diamines DAO (B6+Cu) and B2 breaks down monoamines MAO (B2+Mg), thus vital to lower allergies.
- B6 + Mg = B6 activates many (most? all?) activities (e.g., Mg is a powerful insulin sensitizer in the glucose metabolism) of Mg, and helps maintain Mg inside the cells. So it can shift the Ca/Mg balance towards Mg if taken in excess
- B6 is needed to progesterone synthesis
- B6 + vitamin D = glucose metabolism and thyroid hormone (thus increasing the need for Iodine and Selenium). Thyroid hormone has a known effect on lipid metabolism, so B6 could be indirectly implicated.
- B6 is needed in the glycine pathway to avoid endogenous oxalate formation
- B6 + Mg + Ca + K2 = dental health
- Methylation of Hcy into Met (anti-oxidant protection of endothelium), sulfur metabolism via CBS
My experience with it:
Taking 60mg of vitamin B6 in a Bcomplex with various dosages of other Bs completely blocked B6 activation in the body (I know because I had symptoms related with the functions mentioned above, for instance alarmingly low serotonin from any tiny increase or decrease in B2 which I kept between 2 and 8mg).
Taking 6mg of P5P daily caused me hyperthyroidism (had to stop my hormone replacement and take lots of Selenium) and serotonin syndrome (unbalance with B2 caused serotonin to build up causing migraine, anorexia/nausea, hypersalivation and rhabdomyolysis) after 10 days.
Cleared a psoriasis-like patch in my neck, helps with dandruff (my dandruff is from histamines?!).
Nice feeling of hands and feet warming up after a meal containing meat, chicken or fish (like the body actually making energy from B12 and iron).
Occasional numbness (esp. arms) even taking tiny doses - taking B12 helps.
My husband gets bacterial symptoms from P5P – cough and furunculosis which subside by increasing arginine in his diet by eating nuts – OR this is oxalate dump which stops by eating more oxalates.
Research on it doesn't seem to consider the blocking effect of large doses of B6/absence of P5P in the supplements on its own metabolism.
( @dannybex perhaps you can gain some insights on your B6 problems?)
This (Linus Pauling Institute) is probably the most extensive review on vitamin B6 online.
B6 interactions with hormones
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