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Intrinsic Functional Hypoconnectivity in Core Neurocognitive Networks Suggests Central Nervous System Pathology in Patients with Myalgic Encephalomyelitis: A Pilot Study.
Zinn ML1, Zinn MA2, Jason LA2.
Author information
1Department of Community Psychology, Center for Community Research, DePaul University, Chicago, IL, 60614, USA.
2Department of Community Psychology, Center for Community Research, DePaul University, Chicago, IL, 60614, USA.
Appl Psychophysiol Biofeedback. 2016 Feb 11. [Epub ahead of print]
Abstract
Exact low resolution electromagnetic tomography (eLORETA) was recorded from nineteen EEG channels in nine patients with myalgic encephalomyelitis (ME) and 9 healthy controls to assess current source density and functional connectivity, a physiological measure of similarity between pairs of distributed regions of interest, between groups. Current source density and functional connectivity were measured using eLORETA software. We found significantly decreased eLORETA source analysis oscillations in the occipital, parietal, posterior cingulate, and posterior temporal lobes in Alpha and Alpha-2. For connectivity analysis, we assessed functional connectivity within Menon triple network model of neuropathology. We found support for all three networks of the triple network model, namely the central executive network (CEN), salience network (SN), and the default mode network (DMN) indicating hypo-connectivity in the Delta, Alpha, and Alpha-2 frequency bands in patients with ME compared to controls. In addition to the current source density resting state dysfunction in the occipital, parietal, posterior temporal and posterior cingulate, the disrupted connectivity of the CEN, SN, and DMN appears to be involved in cognitive impairment for patients with ME. This research suggests that disruptions in these regions and networks could be a neurobiological feature of the disorder, representing underlying neural dysfunction.
KEYWORDS: Chronic fatigue syndrome; Lagged phase synchronization; Myalgic encephalomyelitis; Triple network model; eLORETA
PMID: 26869373 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/26869373
Zinn ML1, Zinn MA2, Jason LA2.
Author information
1Department of Community Psychology, Center for Community Research, DePaul University, Chicago, IL, 60614, USA.
2Department of Community Psychology, Center for Community Research, DePaul University, Chicago, IL, 60614, USA.
Appl Psychophysiol Biofeedback. 2016 Feb 11. [Epub ahead of print]
Abstract
Exact low resolution electromagnetic tomography (eLORETA) was recorded from nineteen EEG channels in nine patients with myalgic encephalomyelitis (ME) and 9 healthy controls to assess current source density and functional connectivity, a physiological measure of similarity between pairs of distributed regions of interest, between groups. Current source density and functional connectivity were measured using eLORETA software. We found significantly decreased eLORETA source analysis oscillations in the occipital, parietal, posterior cingulate, and posterior temporal lobes in Alpha and Alpha-2. For connectivity analysis, we assessed functional connectivity within Menon triple network model of neuropathology. We found support for all three networks of the triple network model, namely the central executive network (CEN), salience network (SN), and the default mode network (DMN) indicating hypo-connectivity in the Delta, Alpha, and Alpha-2 frequency bands in patients with ME compared to controls. In addition to the current source density resting state dysfunction in the occipital, parietal, posterior temporal and posterior cingulate, the disrupted connectivity of the CEN, SN, and DMN appears to be involved in cognitive impairment for patients with ME. This research suggests that disruptions in these regions and networks could be a neurobiological feature of the disorder, representing underlying neural dysfunction.
KEYWORDS: Chronic fatigue syndrome; Lagged phase synchronization; Myalgic encephalomyelitis; Triple network model; eLORETA
PMID: 26869373 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/26869373