Just wondering whether Yasko does anything to determine how genetic mutations are expressing. I am uncomfortable with assuming that all my 23andme mutations are expressing. That is because I have a homozygous CBS mutation but have taken MSM (organic sulfur) and several other sulfur based supplements with no consequence for over 30 years. In fact, MSM is one of the supplements that has helped me the most with aching and food allergies. I'm also uncomfortable with having the autism lens applied to most genetic mutation interpretations. The CBS mutation can also be down regulated rather than unregulated, which is what causes the problem with sulfur and ammonia. I actually have more indications symptomatically of having a down regulation. Any thoughts?
Yasko isn't a medical practitioner, so she presumably isn't treating patients and wouldn't be determining their actual gene expression.
Yasko is also completely wrong about CBS. The +/+ versions are mild and beneficial up-regulations. When the gene becomes dysfunctional and causes serious problems, it's due to severe down-regulation. Basically there's no credible connection between the CBS SNPs tested by Yasko, and the symptoms which Yasko claims are caused by them.
Additionally, trying to "slow down" the gene by avoiding B6 or other methods would have a downstream effect, reducing the production of glutathione, as well as potentially raising homocysteine.
My general impression is that Yasko's theories and advice regarding CBS are completely wrong, and following her protocol for it is potentially harmful.