Hi Arx;
It's possible that you are experiencing what Rich has described as overdriving the methylation cycle.
I'm trying to understand what is happening biochemically, but I'm limited in that way, and I'm not sure that all is known about methylation.
So I'll just bring up what helps me with this process. I find that I'm having to develop my own personal protocol, because some supplements work well for me, and others...not so well. Not only must I find which supplements are effective, but what specific amounts work better. With some, I need higher amounts, but with most, I need lower. For a time, I was trying individual B vitamins to find my own type of B complex. I'll probably continue this, but with less extremes than before.
I also find that the adB12 can be overstimulating. I only take small amounts once every two weeks or so. I reduced folate to 600-800 mcg. daily now. I do, however, need higher amounts of B12. I take a low dose B complex daily. ( I consider low dose to be less than 25 mgs. daily).
These amounts work well for me, but other folks find they need higher or lower dosages for their own protocol.
Zinc has really helped me with the wired feeling of anxiety, agitation, irritablity, and insomnia. I generally take a supplement with 15mg. zinc and 1 mg. copper. in the morning with breakfast. It has taken a few months for these symptoms to subside, but each day has become noticably better.