Does anyone know if anyone ever tried Brincidofovir for EBV? My hopes are not too high for it, but the data looked kind of promising (post #2 in this thread). About a year ago there was a group buy for Brincidofovir that was trying to get rolling, but progress was very slow, not sure if it ever happened.
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Which drugs are effective against herpesviruses HSV, EBV, CMV, VZV, HHV6, HHV8?
- Thread starter Pyrrhus
- Start date
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- Tags
- antivirals herpesviruses
Forummember9922
Senior Member
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- 166
Is there a way to attain it ? When I searched I could not find a vendor.
I am surprised more have not tried Amenalief the Japanese Pritelivir but it is quite expensive
Charles555nc
Senior Member
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- 572
Source for Amenalief?
Forummember9922
Senior Member
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- 166
I recommend bio-japan. Keep in mind theres no testimonials at all of it having positive effects on cfs. Then again theres pretty much one testimonial. If you have lingering hsv issues could be more appropriate and theres also moderna and gsk hsv vax trials starting phase 1 within months
Thank you so much for this. So my wife got CFS/ME after getting mono/EBV infection about 16 years ago. We did titers and tests a year ago and it shows that she has a history of infection with EBV and CMV and also HHV6. But none area currently reactivated. However, her symptoms are still severe. (IGG positive but IGM is not) Do you know if there are anyone who gets benefits from these even if IGM is negative? Could a very low level of the virus in the body continues to trigger autoimmune response but not enough to be detected by IGM?
Tammy
Senior Member
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Tests for EBV can be elusive and herein lies a big medical blunder. EBV can hide deep in the tissues, organs and central nervous system where it cannot be picked up in tests. The virus can most definitely keep causing problems despite what the tests say.
heapsreal
iherb 10% discount code OPA989,
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- australia (brisbane)
It won't say a specific virus is active but if you get a lymphocyte subset test done, it is common to see a high cd8 t cell count in active ebv and other herpes viruses. So it can give you a clue that ebv is possibly active. With antiviral treatment, if it's a herpes virus, you will see the cd8 t cell count go down to a normal range which can take a few months or longer, atleast trending down.
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Treeman
Senior Member
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- 793
- Location
- York, England
I thought I would offer some of my experiences to this thread.
I have been diagnosed with ME CFS and pan-hypogammaglobulinemia, low IgG, IgM and IgA. I have been on both acaclovir and valciclovir as a prophylactic but have still had a constant rash on the neck which was originally diagnosed as shingles. I recently tried famicilovir for 10 days and the infection got worse.
My immunologist has eventually agreed to a biopsy to try and discover the infection. He thinks it could be HSV1 or shingles.
What I've discovered is that shingles (or what ever my persistent infection is) can become resistant to acaclovir, valciclovir and probably famicilovir. Possibly other infections it's designed for too?
I'm also on immunoglobulin therapy and this did show signs of controling the infection and I started to feel better with a little more energy after about 4 months. However I then caught an infection and 6 months later still haven't recovered. The obvious thing to conclude is that it was possibly a COVID 19 variant, but I never tested it.
I started a course of cimetidine 20 days ago, but this shows no signs of improvement in my infection and general health.
I've also been able to get hold of (or at least it should be in the post soon) 14 days of Zostex, but reading through the information on this, it's best administered at the beginning of the infection and not in my case after years of it being active.
I'm in the UK with the NHS and the wait for an appointment is approximately 6 months and then there will be a further wait for the biopsy. So I won't have any answers soon.
I have been diagnosed with ME CFS and pan-hypogammaglobulinemia, low IgG, IgM and IgA. I have been on both acaclovir and valciclovir as a prophylactic but have still had a constant rash on the neck which was originally diagnosed as shingles. I recently tried famicilovir for 10 days and the infection got worse.
My immunologist has eventually agreed to a biopsy to try and discover the infection. He thinks it could be HSV1 or shingles.
What I've discovered is that shingles (or what ever my persistent infection is) can become resistant to acaclovir, valciclovir and probably famicilovir. Possibly other infections it's designed for too?
I'm also on immunoglobulin therapy and this did show signs of controling the infection and I started to feel better with a little more energy after about 4 months. However I then caught an infection and 6 months later still haven't recovered. The obvious thing to conclude is that it was possibly a COVID 19 variant, but I never tested it.
I started a course of cimetidine 20 days ago, but this shows no signs of improvement in my infection and general health.
I've also been able to get hold of (or at least it should be in the post soon) 14 days of Zostex, but reading through the information on this, it's best administered at the beginning of the infection and not in my case after years of it being active.
I'm in the UK with the NHS and the wait for an appointment is approximately 6 months and then there will be a further wait for the biopsy. So I won't have any answers soon.
Treeman
Senior Member
- Messages
- 793
- Location
- York, England
I'm a patient with immunology. They have sent me to infectious diseases and rheumatology (both as usefull as a plastic frying pan). I'm now being referred to dermatology due to the infection on the skin.
Learner1
Senior Member
- Messages
- 6,305
- Location
- Pacific Northwest
Antibody tests can be pretty useless. I had several doctors miss HHV6 and EBV because they did antibody tests. Doing quantitative PCR tests showed I was positive for both, and getting on valganciclovir gave me my life back.
Dude
Senior Member
- Messages
- 190
Sorry if this has been asked before, but how long did it take before you noticed something? What was your dose?
I'm just asking because I want to test it too.
Learner1
Senior Member
- Messages
- 6,305
- Location
- Pacific Northwest
Sorry, not sure what you're asking.
I tracked my illness and recovery with an Oura ring and lab tests.
Most ME/CFS seems to be related to untamed infections which cause mitochondrial fragmentation and depletion of nutrients which leads to a cascade of secondary and tertiary problems, along with a dysfunctional immune system, one that doesn't appropriately fight infections while ongoing smoldering infections trigger all sorts of autoimmunity in a we au that differs from patient to patient.
Rather than expecting that taking ng a single pill is going to lead to recovery, it's more important to support the immune system, tackle the infections with appropriate treatments, and calm the autoimmunity while supporting the mitochondria and body with nutrients to encourage recovery.
What dose of valganciclovir did you take ? Did you titrate up to it? How long until you started to see improvements? Thank you!
Violeta
Senior Member
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- 2,952
This article is about a botanical topical used to treat shingles.
https://journals.lww.com/md-cases/f...tment_of_herpes_zoster_with_botanical.13.aspx
I can't find the product, but here's some information about it.
"... the patient was prescribed a commercially available botanical formulation (Aviratek Biomedical Solutions) of ethanol and/or glycerin extracted Hypericum perforatum (2.5%), Lavandula officinalis (10%), Glycyrrhiza glabra (2.5%), Melissa officinalis (6%), Eleutherococcus senticosus (4%) and mixed species of Sarracenia (25%) suspended in a Versabase gel (50%). The Versabase gel was composed of allantoin, aloe vera, ammonium acryloyldimethyltaurate, ethylenediaminetetraacetic acid and methylchloroisothiazolinone."
https://journals.lww.com/md-cases/f...tment_of_herpes_zoster_with_botanical.13.aspx
I can't find the product, but here's some information about it.
"... the patient was prescribed a commercially available botanical formulation (Aviratek Biomedical Solutions) of ethanol and/or glycerin extracted Hypericum perforatum (2.5%), Lavandula officinalis (10%), Glycyrrhiza glabra (2.5%), Melissa officinalis (6%), Eleutherococcus senticosus (4%) and mixed species of Sarracenia (25%) suspended in a Versabase gel (50%). The Versabase gel was composed of allantoin, aloe vera, ammonium acryloyldimethyltaurate, ethylenediaminetetraacetic acid and methylchloroisothiazolinone."