What kind of peptide contaminant could be causing this reaction?

[marcjf]

Looking for some information that can help me investigate this. I am reacting badly to pretty much every peptide, and it is a very weird and delayed reaction, not an allergic one.

I develop some delayed tendonitis and muscle pain some days later after application, only seeming to subside days after stopping, although there may be some lasting damage.

I am not getting my peptides from a compounding pharmacy, and maybe that is the issue. I was getting them from suppliers widely accepted as legit, like Canlabs. Never from more obscure sellers.

For example, bought BPC-157 subq from CanLab. I mixed it with BAC water (Hospira brand). Started fine, and I was actually even getting benefits out of this peptide, no immediate reaction. 1 week into it and I started developing muscle/tendon issues. I stopped the peptide, and the issues persisted for a couple of days until subsided.

Then spent many months without trying anything, got spooked with injectables. Decided to try VIP Nasal spray (not injectable). This one is from Limitless, and they ship deionized water to be used with that. I was doing fine for 1.5 weeks. But once again the same muscle pain and tendonitis start showing, all over my body. I can feel the damage.

So annoying. My question is what could be causing this? I do not think it is the actual peptide. VIP, for example, is something that is produced endogenously. And it has a really short half-life of a couple of minutes, it does not build up. I feel like there is a toxin building up slowly in my body when I am using these.

I heard from at least one peptide doctor that these online sellers never test/remove endotoxins, so I am guessing that may be the issue. But I am not getting any fever, so I am not sure. Also it does not explain why only I get these issues with these providers, and 99% of other people do it just fine.

 

[SWAlexander]

can help me investigate this

Have you looked into "effects of collagen peptides on muscle damage or inflammation?"

 

[YippeeKi YOW !!]

Peptides are short strings of amino acids, and your reaction might be due more to loading on one form of peptide that in some way interferes with the uptake or utilization, or even existence, of others that might be critical to muscle and tendon reactions ....

Also what @SWAlexander said ....

Not having best brain (or anything else) day, so am thinking 'horses' more than 'zebras' ....

VIP, for example, is something that is produced endogenously.

So is thryoid hormone, but too much or too little can be brutally unpleasant in its effects ....

 

[marcjf]

Peptides are short strings of amino acids, and your reaction might be due more to loading on one form of peptide that in some way interferes with the uptake or utilization, or even existence, of others that might be critical to muscle and tendon reactions ....

Also what @SWAlexander said ....

Not having best brain (or anything else) day, so am thinking 'horses' more than 'zebras' ....

So is thryoid hormone, but too much or too little can be brutally unpleasant in its effects ....

I am sorry, just not sure how anything that has been mentioned so far is related to my question.

No such thing as loading of VIP. It has a half-life of 2 minutes only. It is sold as a drug as well (ZYESAMI), and there is no mention of tendinopathies as a reported side effect. And even if there was, why would I get the same side effect from a completely different peptide (BPC-157) from a different supplier and used in a different manner (injectable)?

I would love to get some input of people that have experience with research peptides. I am pretty sure there is a contaminant somewhere, but do not know why it is only me reacting to it.

 

[mitoMAN]

Looking for some information that can help me investigate this. I am reacting badly to pretty much every peptide, and it is a very weird and delayed reaction, not an allergic one.

I develop some delayed tendonitis and muscle pain some days later after application, only seeming to subside days after stopping, although there may be some lasting damage.

I am not getting my peptides from a compounding pharmacy, and maybe that is the issue. I was getting them from suppliers widely accepted as legit, like Canlabs. Never from more obscure sellers.

For example, bought BPC-157 subq from CanLab. I mixed it with BAC water (Hospira brand). Started fine, and I was actually even getting benefits out of this peptide, no immediate reaction. 1 week into it and I started developing muscle/tendon issues. I stopped the peptide, and the issues persisted for a couple of days until subsided.

Then spent many months without trying anything, got spooked with injectables. Decided to try VIP Nasal spray (not injectable). This one is from Limitless, and they ship deionized water to be used with that. I was doing fine for 1.5 weeks. But once again the same muscle pain and tendonitis start showing, all over my body. I can feel the damage.

So annoying. My question is what could be causing this? I do not think it is the actual peptide. VIP, for example, is something that is produced endogenously. And it has a really short half-life of a couple of minutes, it does not build up. I feel like there is a toxin building up slowly in my body when I am using these.

I heard from at least one peptide doctor that these online sellers never test/remove endotoxins, so I am guessing that may be the issue. But I am not getting any fever, so I am not sure. Also it does not explain why only I get these issues with these providers, and 99% of other people do it just fine.

my friend with FQAD has the same exact problem. No matter if official pharmacy or selfmade peptide.
Our pharmacologist thinks its the PAR2 receptor (If im not mistaken) interacting with many peptides, so it might be a mast cell issue you are encountering.

BTW BPC, TB-4 and GHK is also prodouced endogenously - like many peptides. He flares up like you from all of them.

 

[marcjf]

my friend with FQAD has the same exact problem. No matter if official pharmacy or selfmade peptide.
Our pharmacologist thinks its the PAR2 receptor (If im not mistaken) interacting with many peptides, so it might be a mast cell issue you are encountering.

BTW BPC, TB-4 and GHK is also prodouced endogenously - like many peptides. He flares up like you from all of them.

Thank you very much for the information. It is very helpful to know that

Even though I never used fluoroquinolones, I was suspecting I have something similar to FAQD patients, since my tendons are flaring pretty much the same way those patients describe.

My next step was going to be trying from official compounding pharmacy, but I think I will not risk that.
It is so frustrating that I cannot use any of them.

 

[YippeeKi YOW !!]

No such thing as loading of VIP. It has a half-life of 2 minutes only.

Since you took it for its beneficial effects, in spite of its 2 minute half-life, it isn't impossible that less-than-positive side effects could be expected from the same 2 minute window of action.

It is sold as a drug as well (ZYESAMI), and there is no mention of tendinopathies as a reported side effect.

There was no mention of the multiple deaths resulting from COX2 inhibitors either, until they were unignorable, or other FDA approved medications ....

I am sorry, just not sure how anything that has been mentioned so far is related to my question.

Good luck, and sorry I apparently wasted your time.