I don't feel the need to do the genetic testing, either. It would be interesting, though, to see if the supposed solutions for the specific findings produce reversal of polymorphisms.
In all my looking up about pau d'arco I've never found anyone to find it unsafe. I looked at the link you provided about internal bleeding, and all causes mentioned were trauma. Nothing about pau d'arco. You can make a tea out of it and replace all your liquids, and probably get better from a lot of different stuff.
Is WebMD sponsered by pharmaceuticals? Just wondering. They don't like effective alternative remedies. Olive leaf isn't as effective as pau d'arco, at least in my experience.
If the deadlock quartet undoes partial methylation block and methytrap and partial ATP block in hours, then the effects should remain, right? If you undo the block, you're good? Is that what undoing the block means?
You do make the deadlock quartet sound easy, but I've seen so many people not do well with it. Are you sure it's undoing the blocks?
Hi Violeta,
In all my looking up about pau d'arco I've never found anyone to find it unsafe. I looked at the link you provided about internal bleeding, and all causes mentioned were trauma. Nothing about pau d'arco. You can make a tea out of it and replace all your liquids, and probably get better from a lot of different stuff.
I have no idea. Believe what you want. However, if the problem is lack of MeCbl, AdoCbl. l-methylfolate or LCF, NOTHING at all can replace them and heal anybody from the deficiencies. A person with these things have usually had years or decades of nothing working at all and lots of bad reactions to many of the things
If the deadlock quartet undoes partial methylation block and methytrap and partial ATP block in hours, then the effects should remain, right? If you undo the block, you're good? Is that what undoing the block means?
It lasts as long as you take the items needed in the combinations and amounts needed. MeCbl deficiency symptoms start returning around the third day without. With methylfolate and it's 3 hour serum halflife, symptoms can start retuning within a day or 3. LCF deficiency symptoms start coming on about the 3rd day as well. In about 30 days the serum level can return to the point of methyltrap being re-established. By taking the nutrients doesn't cure the cause of the deficiencies, they merely temporarily replace the items.
You do make the deadlock quartet sound easy, but I've seen so many people not do well with it. Are you sure it's undoing the blocks
Well first, partial methylation block, methyl-trap and partial ATP block (mito malfunction? or anything else one might want to call it) are all to one degree or another hypothetical, in some cases for 50 years or more. Many things, many symptoms, many studies, depending upon how interpreted and the experience of thousands and thousands of people appear to back up. The Deadlock Quartet is not easy. That is a major aspect of the problem. My internist has watched with amazement but says that it is almost impossible to get good compliance with 3 meds on different schedules each day much less something with dozens of different items in some critical time relationships to each other.
So realizing that all three of these items, as well as the hypothetical paradoxical folate deficiency, are largely recognized by inferance from symptoms or certain biochemical signatures. So the evidence for methyl block are things like low glutathione (Rich), high MCV and other blood changes, presence of excessive homocysteine is usually a marker for a methylation breakdown, MMA a marker for the breakdown of making ATP. From excess MMA and fatigue it can be inferred that not enough ATP is getting made. Lack of ATP disables hundreds of enzymes which cause hundreds of different kinds of failures which we all see the effects of every day.
Have your genuinely healthy friends, ones with NONE of these symptoms we have, try them. Approximately 20% will respond to a noticeable amount and almost always say "I had forgotten about those because my doctor said they were non-specific and meant nothing" or "I'd forgotten about how tired I've been getting". The rest will say "What is all the fuss about. These do nothing at all." or something approximating that. The doses I've used on that test are typically 1-3mg of MeCbl/AdoCbl 5mg and 10mg made no difference in any way and nobody could distinguish the difference at first dose.
Those that have these symptoms typically react immediately, about 95%, and often like a ton of bricks intensity. The other 5% react to some other deficient vitamin or nutrient or combinations of the same. Vitamin D is a common one, Biotin, SAM-e, TMG, magnesium, zinc, vit C.
When you have 600 or thereabouts biochemical processes starting all at once it can hit like a ton of bricks. The most unexpected thing I have seen is the huge difference LCF makes for most and that only about 10% find that ALCAR works instead. That points exactly at the transport of fat for Krebs cycle and perhaps some possible genetic difficulty in synthesizing the LCF form. It must be absorbed in an empty stomach as it is merely digested to amino acids if eaten with food or at least it acts that way.
The various pathways breakdown into about half a dozen main ones with variations farther down the path in massive quantity. The most common types of reactions people have are predictable. That they are going to have a major response is very predictable in advance.
The two items below are from the collected affects, regardless of whether they agree with my hypothetical basis or not, their responses whether called intolerable side effects or flags of healing and startup responses, they almost always fit right in. One person's "detox" is another persons induced deficiencies of potassium and folate that can be corrected, among other things.
B12 ZONES – Version 3.0 10/26/2012
This is the recent re-conceptualization taking recent knowledge into account
I. ACTIVE TRANSPORT ONLY ZONE - Oral or injected cyanocbl or hydroxcbl, about 10mcg possible absorption via active means per meal and ends up transported by HTCII and subject to the body’s triage methods. Weakly dose proportionate up to doses of 125mcg orally, saturating the active transport system. Limited symptom effectiveness.
II. DIFFUSION – BODY TRANSPORT ZONE - Sublingual proven effective (5 star) methylb12 and adenosylb12 500mcg (approx 100mcg absorbed) or 100mcg injection. Threshold dose for “turning on healing”. Strongly dose proportionate 1-100mcg absorbed. Moderately dose proportionate 100-3000mcg absorbed, weakly dose proportionate 3000-20,000?mcg absorbed.
III. DIFFUSION – CSF/CNS TRANSPORT ZONE – An estimated serum cobalamin level of 100,000pg/ml to 200,000pg/ml maintained 24/7. 7.5mg QID, 10mg TID or 15mg BID of 5 star mb12 has worked for many trying it. Threshold effect at between 6 and 7.5mg SC injection.
IV. INTRATHECAL INJECTION 2.5MG METHYLB12– Japanese research has tried this and found effectiveness lasted 3 months to 4 years (latest report)
THE 95% REASONS B12 AND FOLATE THERAPIES FAIL
Version 2.0 - 03/10/11, Version 2.1 - 05/08/11. Version 3.0 – 10/25/2012, Version 3.1 10/26/2012, Version 11/05/2012 3.2
1) They take an inactive b12, either cyanob12 or hydroxyb12. The research validating their use was primarily for reducing blood cell size in Pernicious Anemia, keeping the serum b12 level over 300pg/ml at the end of the period between injections. They make a statistically significant effect that can be seen in lab tests in a significant percentage of people compared to placebo. They do not heal most damage done by active b12 deficiencies and have little or no effect on the vast majority of symptoms. They may even block active b12 from receptor sites hindering the effects of real b12. They both cause a keyhole effect of having only a very limited amount (estimated at 10-30mcg/day) that can actually be bound and converted to active forms. They in no way increase the level of unbound active cobalamins which appear required for most healing. They do nothing beneficial in a substantial percentage of people (20-40%) while giving the illusion that the problem is being treated and if it doesn’t work, oh well, that’s the accepted therapy. There is no dose proportionate healing with these inactive b12s because it all has to go through this keyhole. Some people are totally incapable of converting these to active forms because they lack the enzymes or ATP
2) They take active b12 as an oral tablet reducing absorption to below 1%. A 1000mcg active b12 oral tablet might bind as much as 10mcg of b12. Again the b12 has to be squeezed through a keyhole that limits the amount and is subject to binding problems in the person whether genetic or acquired.3. They take a sublingual tablet of active b12 and chew it or slurp it down quickly reducing absorption back to that same 1% and limited to binding capacity. With sublingual tablets absorption is proportionate to time in contact with tissues. I performed a series of absorption tests comparing sublingual absorption to injection via hypersensitive response and urine colorimetry.
3) Of the many brands of sublingual methylb12 only some are very effective. Some are completely ineffective and some have a little effect.
4) For injectable methylb12, if it is exposed to too much light (very little light actually is too much) it breaks down. Broken down methylb12 is hydroxyb12. It doesn’t work at healing brain/cord problems of those who have a presumed low CSF cobalamin level. That requires a flood of unbound methylb12 and adenosylb12 (2 separate deficiencies) that can enter by diffusion. Adenosylb12 from sublinguals can ride along with injected methylb12.
5) They don’t take BOTH active b12s.
6) They don’t take enough active b12s for the purpose.
7) Lack of methylfolate
8) Lack of sufficient Methylfolate, a dose can start more healing than the same dose can complete.
9) Paradoxical Folate Deficiency - Folic acid is taken which can block at least 10 times as much methylfolate from being active inducing folate deficiency even if methylfolate is also taken. These induced deficiency symptoms are often called "detox" symptoms. Folinic acid is taken which can block at least 10-20 times as much methylfolate from being active inducing folate deficiency even if methylfolate is also taken. These induced deficiency symptoms are often called "detox" symptoms.
10) Lack of l-carnitine fumarate (rarely ALCAR), the 4th of the Deadlock Quartet
11) Lack of other critical cofactors.
12) Lack of basic cofactors
13) Glutathione, glutathione direct precursors, NAC and /or whey is taken causing what is often called "detox" while actually being induced folate and b12 deficiencies.
14) Having many additional supplements and herbs of unknown interactions and effects.