datadragon
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Upon further verification, my high B6 levels are not pyridoxine, but rather P5P. So it looks like it's not an activation problem.... its looks like it's just accumulating. ...
Yeah but I called the lab and my high B6 values are actually p5p, so it's already active. And I never supplemented B6
Plasma P5P (called PLP) shows an inverse relation to C-reactive protein (CRP) and other inflammatory markers, and would also potentially increase homocysteine which activates NLRP3 inflammasome when low and increase inflammatory markers. So perhaps checking c-reactive protein and homocysteine and any other indirect markers here or what your doctor may want to check might be useful https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5988249/
Participants in the highest quartile of plasma PLP had lower plasma fasting glucose and HbA1c concentrations than those in the lower quartiles. Higher plasma PLP was significantly correlated with higher HDL cholesterol So those might also be used to confirm low utilization of the high B6 or its not active. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806890/
Mercury in nanomolar concentrations inhibits the intestinal pyridoxal kinase, activator of Vitamin B6 https://pubmed.ncbi.nlm.nih.gov/4252567/
And if it is actually P5P, perhaps the low zinc from high inflammation may also be needed for utilization of the b6. The intestinal absorption of both PNP and PMP (phosphorylated animal forms), as well as the final tissue uptake of circulating PLP requires a different enzyme that has zinc as a co-factor. Riboflavin, or vitamin B2, is needed for the phosphorylation of all forms of absorbed B6 to active PLP in the liver. Thus, poor intakes of zinc and/or riboflavin may exacerbate or lead to B6 deficiencies https://www.westonaprice.org/health...ion/vitamin-b6-the-under-appreciated-vitamin/
That might suggest trying first to lower the inflammation with NLRP3 inhibitors to allow zinc to be available to do its functions or taking a zinc amino acid form that bypasses the natural uptake issue during inflammation may help. Sounds like you may need to avoid higher B6 containing foods and supplements as well until it comes down.
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