When your body becomes overmethylated there’s too much SAMe floating around. if you are an over-methylator you can take certain supplements to decrease methylation. Excess niacin (B3) is metabolized by methylation and thus uses up methyl groups. So if you are an over-methylator, meaning you have extra, then B3 is good because it uses them up, but if you are an under-methylator, meaning deficient, then giving extra B3 is bad because it drains an already poor supply.
https://mthfr.net/overmethylation-and-undermethylation-case-study/2012/06/27/ Methylation is simply the adding or removal of the methyl group to a compound or other element. A "methyl" group is simply one carbon connected to three hydrogen atoms which is why this process is called methylation.
While hypomethylation is associated with many different problems, hypermethylation can be equally problematic. What we really need is methylation balance in the body. Many on their own or at the recommendation of their healthcare practitioner, have sought genetic testing for MTHFR and other genes related to methylation and begun supplements to correct their supposed “methylation deficiency” based solely on their genetic results. However, because someone has an SNP that might predispose them to impaired methylation does not mean they actually have impaired methylation. In fact, they could have completely normal methylation! On the other hand, a person who has no SNPs in their methylation genes could have severe methylation imbalance and may therefore benefit from some treatment. This is similar to what I've posted about inflammation in general, its important to test what your body state actually is rather than follow advice to take high dosing of anti inflammatory nutrients which also would be problematic if not currently in an inflammatory state.
...yes, there are mutants out there, walking among you, but unlike the comics they dont get to turn to ice or rock or fly but unable to convert regular old folic acid into methylfolate, or 5-MTHF for short. I will stand with pride among you because yes, I too am a mutant. The presence of methylenetetrahydrofolate reductase (MTHFR) genotypes, in particular, C677T, or A1298C mutations, directly impact enzymatic activity in the methylation process but that does not mean its necessarily bad in general, perhaps only when going too far in one direction and having health problems related to that imbalance.
One reliable and effective method of doing this is through the use of a whole blood histamine test. This is different from a plasma histamine blood test which is a histamine test that looks at histamine in the plasma, the fraction of blood which carries the blood cells throughout the body. While doctors often test plasma histamine in persons with histamine intolerance, the majority of histamine present in the body is within the whole blood cells of white blood cells, specifically basophils and mast cells. Whole blood cells are utilized for testing methylation status because within those cells are a methyl-dependent enzyme which is what controls the level of histamine, giving physicians an understanding of ones true methylation status. One way histamine is de-activated (eliminated) is by receiving a methyl group from SAMe. So if there is low methylation, there is low SAMe, and the histamine levels are higher because of the lack of methyl groups to deactivate it. If there is high methylation, there is higher amounts of SAMe, and lots of histamine can be deactivated.
https://www.secondopinionphysician.com/shop/walsh-protocol-lab-test-histamine-methylation/
