What does Molybdenum do?
- Thread starter DogLover
- Start date
Seems to hinder its absorption and blocking copper-dependent enzymes:
https://lpi.oregonstate.edu/mic/minerals/molybdenum
https://lpi.oregonstate.edu/mic/minerals/molybdenum
pamojja,
Thank you for your response!
Sorry for my ignorance, but that's a little over my head. Could you dumb that down in terms of why it would be prescribed for someone high in copper?
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I didn't even knew about tetrathiomolybdate or that is prescribed for Wilson disease, until I just read it there. Nor would I know where tetrathomolybdate would be available. That's what this articles says:
English is only my second language too, but what they are basically saying is that it lowers copper. But don't think that applies to supplemental amounts of Molybdenum.
English is only my second language too, but what they are basically saying is that it lowers copper. But don't think that applies to supplemental amounts of Molybdenum.
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I found this on Wikipedia of all places....
Copper-molybdenum antagonism
High levels of molybdenum can interfere with the body's uptake of copper, producing copper deficiency. Molybdenum prevents plasma proteins from binding to copper, and it also increases the amount of copper that is excreted in urine. Ruminants that consume high levels of molybdenum suffer from diarrhea, stunted growth, anemia, and achromotrichia (loss of fur pigment). These symptoms can be alleviated by copper supplements, either dietary and injection.[92] The effective copper deficiency can be aggravated by excess sulfur.[39][93]
Copper reduction or deficiency can also be deliberately induced for therapeutic purposes by the compound ammonium tetrathiomolybdate, in which the bright red anion tetrathiomolybdate is the copper-chelating agent. Tetrathiomolybdate was first used therapeutically in the treatment of copper toxicosis in animals. It was then introduced as a treatment in Wilson's disease, a hereditary copper metabolism disorder in humans; it acts both by competing with copper absorption in the bowel and by increasing excretion. It has also been found to have an inhibitory effect on angiogenesis, potentially by inhibiting the membrane translocation process that is dependent on copper ions.[94] This is a promising avenue for investigation of treatments for cancer, age-related macular degeneration, and other diseases that involve a pathologic proliferation of blood vessels.[95][96]
Copper-molybdenum antagonism
High levels of molybdenum can interfere with the body's uptake of copper, producing copper deficiency. Molybdenum prevents plasma proteins from binding to copper, and it also increases the amount of copper that is excreted in urine. Ruminants that consume high levels of molybdenum suffer from diarrhea, stunted growth, anemia, and achromotrichia (loss of fur pigment). These symptoms can be alleviated by copper supplements, either dietary and injection.[92] The effective copper deficiency can be aggravated by excess sulfur.[39][93]
Copper reduction or deficiency can also be deliberately induced for therapeutic purposes by the compound ammonium tetrathiomolybdate, in which the bright red anion tetrathiomolybdate is the copper-chelating agent. Tetrathiomolybdate was first used therapeutically in the treatment of copper toxicosis in animals. It was then introduced as a treatment in Wilson's disease, a hereditary copper metabolism disorder in humans; it acts both by competing with copper absorption in the bowel and by increasing excretion. It has also been found to have an inhibitory effect on angiogenesis, potentially by inhibiting the membrane translocation process that is dependent on copper ions.[94] This is a promising avenue for investigation of treatments for cancer, age-related macular degeneration, and other diseases that involve a pathologic proliferation of blood vessels.[95][96]
drmullin30
Senior Member
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Molybdenum has been indispensable to me for copper control. When I have symptoms of copper toxicity, molybdenum, zinc and chromium all provide relief within hours. You can take them all together.
Molybdenum will combine with copper in the blood and bile to facilitate excretion. I have MOCS and CBS SNPS so my molybdenum needs are very high. During copper dumps, I will take up to 6 mg per day of molybdenum.
Strangely, at other times I have copper deficiency and can't take any molybdenum without making the deficiency symptoms worse. I seem to keep cycling between deficiency and toxicity since I started doing methylation protocols. My suspicion is that this is related to oxalate dumping and general detoxification caused by increased methylation.
Molybdenum will combine with copper in the blood and bile to facilitate excretion. I have MOCS and CBS SNPS so my molybdenum needs are very high. During copper dumps, I will take up to 6 mg per day of molybdenum.
Strangely, at other times I have copper deficiency and can't take any molybdenum without making the deficiency symptoms worse. I seem to keep cycling between deficiency and toxicity since I started doing methylation protocols. My suspicion is that this is related to oxalate dumping and general detoxification caused by increased methylation.