May I ask how you experience it?
Like a worse version of my baseline. No clear thoughts, word finding issues, leas cognition, muscle fatigue, more air hunger, headache, oversensitivity to light, dysautonomia, numbness in my finger tips, tachycardia. It takes one night to become notable though. There's another immediate fatigue I experience, which feels like I'm on too many antihistamines. So I explored the possibility that this is maybe histamine-related. Microglia activation might be one explanation.
I did experience an entirely psychologically generated severe "pain" which my body produced. Not an "illness" but a symptom.
I wouldn't call this psychological. If you look at it from this perspective, asthma is psychological as well because it's triggered the same way as your episode. We're generally hypersensitive and this doctor provided the necessary overload. But the mechanism is neurological.
phone really makes me feel more ill really quickly. Holding it, focusing on it if its a video chat (often is, my grandaughter), I often get PEM the next day if the call is very long. And I don' t do that much of the talking
I think it's the subconscious pattern that goes along. We've learned to subconsciously prepare for a talk and a phone call. But our brain might not be ready for this task. So even if we don't consciously focus, our subconscious might be overdoing it. It doesn't mean it's psychological. It's just a physiological process that can't work properly because of the pathophysiology of ME.
From my experience, PEM is neurological, and probably involves glial cells. Cognitive exertion could trigger my PEM within an hour (variable delay).
Same idea. Glutamate activates the glial cells. If the neurons send too much glutamate or if the glial cell receptors are hypersensitive to glutamate, it's a natural response. The question is what mechanism is really at play. It could as well be a dysfunction of GABAergic system as the antagonist of glutamate. This intrigues me about the Coetene theory. But maybe their success is just an indirect one related to glutamate or GABA. I'm certain that antihistamines interact with the pathogenesis, though I'm not sure if it's in a positive or negative way.
would itbe ridiculous to suppose that a gut leakiness could cause intestinal bacterias to go from the intestine to the kidney and then bladder, and that his autovaccine could fix that ?
That's a typical explanation for bladder infection in males. In fact, it's E. Choli that end up in the kidneys, bladder, prostate and urinary tract. In my case, it basically began with a UTI and I've had many UTIs in my relatively young life. Sometimes, I can detect high amounts of blood in the urine, so it's definitely more than just a general inflammation of the urinary tract. I also have traces of coliform bacteria in my drinking water. I think the main issue here is that the reduced acidity in the stomach opens the door to bacterial infections of the GIT and UT.