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Vortioxetine Add-On to Methylphenidate for the Treatment of Symptoms of Sickness Behavior in Attention-Deficit Hyperactivity Disorder 2021


Senior Member
Reports | Free Full-Text | Vortioxetine Add-On to Methylphenidate for the Treatment of Symptoms of Sickness Behavior in Attention-Deficit Hyperactivity Disorder: Report of Two Cases (mdpi.com)

Youth with Attention-Deficit Hyperactivity Disorder (ADHD) may suffer from comorbid difficulties, such as anxiety–depressive symptoms, social withdrawal, and somatic complaints.

Although stimulants remain the ADHD cornerstone treatment, mental fatigue, school problems and low self-esteem may persist, often being the most unacceptable symptoms for these patients. We present two cases of adolescents (14 and 15 years old) with methylphenidate-treated ADHD, where cognitive fatigability, depressive thoughts, anxiety, irritability, and poor social relationships remained.

Based on clinical observation and the completion of parent and child rating scales, the aforementioned manifestations appeared to progressively reduce by the time of the subsequent control visits planned 1, 3, and 5 months after, following the use of vortioxetine (up to 10 mg/day) as add-on therapy to methylphenidate.

No significant side effects were reported in both cases in a follow-up period of 3 months, also supporting the stability of the observed clinical improvement. ...


Senior Member
Hello @pattismith ....... I certainly could have used this information about 52 years ago when my first child was having difficulties, in everything and everywhere. At that time, ADHD wasn't known about, and when it was boys only were affected.

After school hours resulted in me teaching her everything again, just like the teacher had. No help from the school whatsoever...and I'm not even talking about tutoring. We changed her to a small, private school and the teachers worked with us. Funny, more was expected of her and she was able to deliver it.

We worked through the problems, went for counseling (to a person who had experience with this problem) and today she's a fine wife, mother and has a great career. No meds.....but I can't say that I'm her favorite person even today. It doesn't mean that she doesn't love me, but with many of these kids the symptoms can remain. L.