Vitamin B's in the Immunesystem and Infections

percyval577

geometrical disaster
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Is Parenteral Thiamin a Super Antibiotic?
Lee and Zhou, 2018 (letter)

beginn of the letter with case reports
Dear Editor,

Thiamin deficiency could cause high fever and injecting thiamin is likely to eradicate microbial infections as observed in cases in a Chinese labor camp. After exhausting arduous labor, a laborer aged 26 became severely ill on February 15, 1959. As a result, he first developed high fever and headache, which was so severe as if being hit by a hammer, and then was followed by asphyxia – he experienced such intense suffocation as if his chest was bandaged tight by a strong wide belt. His body temperature rose to 41°C. When he was in this condition, he was injected with 10 mg thiamin hydrochloride. Asphyxia and headache dramatically reduced. Temperature dropped to 38.5°C after 1 h although it returned to 39.5°C 2 h later. Another dosage of 50 mg of parenteral thiamin normalized his temperature.

A dying laborer with deep coma, high fever, bigeminy, extensive pulmonary precipitants, and rales in National Hunger 1960 was saved by administering 100 mg of intravenous thiamin in 60 mL of 50% glucose plus 50 mg of intramuscular thiamin but zero antibiotics (Fig. 1).
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The role of thiamine in HIV infections
Luong and Nguyen, 2013

summary, my paragraphes
Patients infected with HIV have a high prevalence of thiamine deficiency.

Genetic studies have provided the opportunity to determine which proteins link thiamine to HIV pathology, i.e., renin–angiotensin system, poly(ADP-ribosyl) polymerase 1, Sp1 promoter gene, transcription factor p53, apoptotic factor caspase 3, and glycogen synthetase kinase 3β. Thiamine also affects HIV through non-genomic factors, i.e., matrix metalloproteinase, vascular endothelial growth factor, heme oxygenase 1, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide.

In conclusion, thiamine may benefit HIV patients, but further investigation of the role of thiamine in HIV infection is needed.
_____​

There are also two investigations on B1 deficiency in parasite infection, one from Egypt and one from Thailand.
google.com/search?q=vitamin+b1+infection
 
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Fascinating! I did an oral experiment taking 1400mg a day and had full amelioration of all symptoms for about 4 days, I did loads! But as others said this doesn't last and soon subsides.

So these injections are fascinating...I wonder if it might help more to supress various pathogens. Would be interested in giving this a go myself.
 

sb4

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Fascinating! I did an oral experiment taking 1400mg a day and had full amelioration of all symptoms for about 4 days, I did loads! But as others said this doesn't last and soon subsides.

So these injections are fascinating...I wonder if it might help more to supress various pathogens. Would be interested in giving this a go myself.
What happens now when you take a big b1 dose? You feel no different?
 

sunshine44

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fascinating. I am doing transdermal application (slowly) and i definitely notice changes after so many failed treatments. I think its not the sole solution for me but very interesting.
 
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@sunshine44 hey what does your transdermal solution consist of? Do you make it yourself? And how long have you been taking it and at what frequency?

And have you been able to notice good changes throughout your entire dosing schedule?

Thank you!
 

sunshine44

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@sunshine44 hey what does your transdermal solution consist of? Do you make it yourself? And how long have you been taking it and at what frequency?

And have you been able to notice good changes throughout your entire dosing schedule?

Thank you!
started in January. Its a liquid 6.0 mg (not much but highest liquid i could find) . I rub it on my thighs. I just got bloodwork and confirmed all of my vitamins are going up through transdermal use (they did not test B1 though).

I noticed my severe heart and left neck/artery pain almost immediately began to stop (i am fully bedridden 4 years) and HRV improved and tachycardia and bradycardia went down. More stabilized moods too. I suspect i have some form of berberi that was never addressed and Drs just have abandoned my case i feel like (bc i'm so severe).
 

sunshine44

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Would you describe this pain as a feeling of pounding on your heart and arteries?

no, severe pain like muscles and cells were being ripped to shreds when trying to move but upon trying to sit up there would be pounding feelings.