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Is Parenteral Thiamin a Super Antibiotic?
Lee and Zhou, 2018 (letter)
beginn of the letter with case reports
The role of thiamine in HIV infections
Luong and Nguyen, 2013
summary, my paragraphes
There are also two investigations on B1 deficiency in parasite infection, one from Egypt and one from Thailand.
google.com/search?q=vitamin+b1+infection
Lee and Zhou, 2018 (letter)
beginn of the letter with case reports
Dear Editor,
Thiamin deficiency could cause high fever and injecting thiamin is likely to eradicate microbial infections as observed in cases in a Chinese labor camp. After exhausting arduous labor, a laborer aged 26 became severely ill on February 15, 1959. As a result, he first developed high fever and headache, which was so severe as if being hit by a hammer, and then was followed by asphyxia – he experienced such intense suffocation as if his chest was bandaged tight by a strong wide belt. His body temperature rose to 41°C. When he was in this condition, he was injected with 10 mg thiamin hydrochloride. Asphyxia and headache dramatically reduced. Temperature dropped to 38.5°C after 1 h although it returned to 39.5°C 2 h later. Another dosage of 50 mg of parenteral thiamin normalized his temperature.
A dying laborer with deep coma, high fever, bigeminy, extensive pulmonary precipitants, and rales in National Hunger 1960 was saved by administering 100 mg of intravenous thiamin in 60 mL of 50% glucose plus 50 mg of intramuscular thiamin but zero antibiotics (Fig. 1).
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The role of thiamine in HIV infections
Luong and Nguyen, 2013
summary, my paragraphes
Patients infected with HIV have a high prevalence of thiamine deficiency.
Genetic studies have provided the opportunity to determine which proteins link thiamine to HIV pathology, i.e., renin–angiotensin system, poly(ADP-ribosyl) polymerase 1, Sp1 promoter gene, transcription factor p53, apoptotic factor caspase 3, and glycogen synthetase kinase 3β. Thiamine also affects HIV through non-genomic factors, i.e., matrix metalloproteinase, vascular endothelial growth factor, heme oxygenase 1, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide.
In conclusion, thiamine may benefit HIV patients, but further investigation of the role of thiamine in HIV infection is needed.
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There are also two investigations on B1 deficiency in parasite infection, one from Egypt and one from Thailand.
google.com/search?q=vitamin+b1+infection