• Welcome to Phoenix Rising!

    Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.

    To register, simply click the Register button at the top right.

Very good (and cheap) Siberian ginseng product

Mary

Mary

Moderator Resource
Messages
17,170
Location
Southern California
Hi @datadragon - I've been taking glycine at night for sleep for 8 or 9 years. The first time I tried it, I had a huge detox reaction, very tired and spacey, got lost going to my sister's house. It's a long story but I learned it was good for me but in very small doses to start with - it's used in Phase II liver detox and at that time I reacted strongly to anything involved with detoxing or cleansing etc. (even apple cider vinegar and cayenne). Eventually after using the glycine (and to a lesser extent inositol and glutamine) in small doses and very gradually increasing by the end of six months my near-constant detoxing stopped. I think primarily the glycine got my detox pathways working.

So I've been taking it at bedtime ever since. The hawthorn is still making a major difference in my sleep but research into it for sleep is almost non-existent unfortunately!
 
datadragon

datadragon

Senior Member
Messages
316
Location
East Coast, USA
I've been taking glycine at night for sleep for 8 or 9 years. So I've been taking it at bedtime ever since. The hawthorn is still making a major difference in my sleep but research into it for sleep is almost non-existent unfortunately!
Click to expand...
Now you know further why glycine was helpful for insomnia. Here is a review on Hawthorn (Crataegus monogyna Jacq.) so you can see all the many components in it. Its interesting that this very long document doesnt even go into sleep but all the other effects! https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8659235/ https://pubmed.ncbi.nlm.nih.gov/23685195/ Its possible to research each component in regards to sleep or other effects. Taking just one line: The flavones apigenin, luteolin and corresponding glycosides compounds such as apigenin-7-O-glucoside, luteolin-3′, 7-diglucoside and rutin were identified

Chamomile flower extract, with more than 2.5 mg of apigenin, was examined for its preliminary efficacy and safety for improving sleep and daytime symptoms in patients with chronic insomnia. According to this study https://pubmed.ncbi.nlm.nih.gov/22370792/ Apigenin increased total sleep time and sleep rate in mice. Another study https://pubmed.ncbi.nlm.nih.gov/11948020/ showed that cortisol levels were decreased in human adrenal cells exposed to apigenin. This is because, at high doses, Apigenin blocks the cortisol-producing enzyme CYP11B1.

This one says these findings seem to support the traditional use of this plant to treat stress, nervousness, sleep disorders, and pain control. https://pubmed.ncbi.nlm.nih.gov/20673180/ Some list sleepiness as a adverse effect! At therapeutic dosages, hawthorn causes very limited adverse effects, such as sweating, headache, mild rash, palpitations, sleepiness, agitation, and gastrointestinal adverse effects https://pubmed.ncbi.nlm.nih.gov/11887407/

Vitexin but no sleep mention in this one https://www.lifeextension.com/wellness/antioxidants/vitexin-health-benefits https://pubmed.ncbi.nlm.nih.gov/27693342/

@Mary
 
You must log in or register to reply here.