Hi dishwashsoap!
Star-Anise, thank you for posting that. What an interesting morning this has been. I did the charcoal and magnesium flush the moment after you posted. I hope it helps. Just two activated charcoal tabs with a bunch of mag citrate and water, right?
Yes, at first I took the charcoal during day (careful to keep away from my other supplements by 2 hours), and then took the magnesium citrate at night. But funny enough I found the magnesium citrate to be stimulating, so took it at other times. I had to do it a couple of times within the first week or two to see a significant clearing of brain fog. It took a couple of times to see any difference with histamine response too.
I have also noted the relationship beween whatever's happening and estrogen dominance.
Me too. Still sorting this relationship out. My hunch the bottom line for me is mercury. Going to get my last "silver" filling out in next month, and then I plan to chelate. I'm looking for non-sulphur chelate agents and am considering using zeolite.
As far as I can see doesn't seem to involve sulphur.... but definitely still researching this one
Do you get little cherry angiomas on your skin, too? I'm told these are from excess estrogen/copper. (Copper builds up with estrogen apparently.)
Ha ha that's so funny. I started to notice some of them a few years ago! Yes, there definitely is this relationship between estrogen dominance and copper toxicity. I crave copper foods like mad around PMS time, although this is decreasing. I have been generally trying to eat low copper.
Do you have any cyp mutations? I am curious to get my 23andme back; I hope they report on that. They are very much related to estrogen metabolism issues. I have been using Rosemary, and Calcium D Glucarate to assist with estrogen metabolism with good progress. Many other common estrogen metabolizers like DIM or I3C rely on sulphur to detox. I also have to eat a diet low in phytoestrogens & grains, as lignans in grains provide a phytoestrogen quality. This has helped immensely. I'm not sure why I have the impaired estrogen metabolism, and hope that the cyp mutation info will help explain. That explains a lot: zinc & relationship to progesterone. The copper toxicity info blew my mind. Apparently people can be copper toxic from birth, which would explain my estrogen dominance symptoms from age 12!!!
Another thing she recommends for the sulphur issue is molyb, which also opposes copper...so I'll be trying that out once this histamine reaction is gone.
I would consider starting it sooner rather than later. But just small, small doses. And manganese as well. These were the next step for me after I did several charcoal flushes.
Anise, were there any other Yasko related tips you've discovered? I'm sort of blown away I never bothered to look into her before considering how spot on she seems.
Ya it was pretty mind-blowing for me too. Her book is so very rich with tonnes of stuff. I will have more to share once I get my own snps back. Her Glutamate-GABA info was quite helpful for me. She confirmed what I know to be the importance of a healthy gut. I'm sure I have a A1298C mutation, but we'll see... Sometimes histamine response can be related to impaired DAO enzyme function, which from my research seems to be related to impaired gut function.
Other than that I'm taking some anti-histamines which are helping minimally.
I would keep taking them though until you get through this phase. I also speculated that increased histamine response could be related to re-activated adrenal function. But really unsure about this. Either way, I found I needed to wean myself off of most supplements that I was taking to support adrenals fast, as they were overdriving my adrenaline response. Really take a close look at all of your supplements. I found that I became so very sensitive to any cofactors in methylation process like Zinc, Vitamin E... in supplement and food sources (like oysters - high zinc).
still feel really hyper/out of it.
If this is just related to the overdose in methyl donors and not a baseline issue, unfortunately might have to wait to flush out. However if you are having issues like this chronically I wonder more about the hyper/out of it symptom. I would read more about the GABA/glutamate balance stuff in Yasko's book and see if any of it rings true for you
Star
