Yeah, pretty much. I'm continuing with NAG and Choline/Inositol, which I started taking during my trial, and a lot of supplements I have been taking for years.
Currently trying out Miyarisan and soon to start b12 injections.
*********Topic : b-cell ***************
rituximab.csv : 28.18 %
b-cells.csv : 26.54 %
chop.csv : 14.98 %
ebv.csv : 12.35 %
cvid.csv : 9.18 %
hypogammaglobulynemia.csv : 9.05 %
xbp1.csv : 4.35 %
immune_response.csv : 2.27 %
pbmc.csv : 2.26 %
il_10.csv : 1.83 %
caspase_human.csv : 1.69 %
p53.csv : 1.45 %
histone_deacetylase.csv : 1.39 %
th1th2.csv : 1.19 %
cyp7b1.csv : 1.16 %
stat1.csv : 1.03 %
vcam-1.csv : 1.02 %
systemic_amyloidosis.csv : 0.97 %
phosphorylation.csv : 0.92 %
upr.csv : 0.89 %
floaters.csv : 0.88 %
glycoproteins.csv : 0.88 %
ubiquitination.csv : 0.88 %
atf4.csv : 0.82 %
glutaredoxin.csv : 0.81 %
biliary_cirrhosis.csv : 0.81 %
perk.csv : 0.80 %
er_stress.csv : 0.79 %
atf6.csv : 0.79 %
gpr78.csv : 0.79 %
5mthf.csv : 0.77 %
ire1.csv : 0.77 %
o-glcnacylation.csv : 0.75 %
nlinkedglycosylation.csv : 0.71 %
redox_homeostasis.csv : 0.71 %
o-glcnac.csv : 0.70 %
dexamethasone.csv : 0.69 %
daoa.csv : 0.68 %
mastocytosis.csv : 0.64 %
thioredoxin.csv : 0.58 %
pdhc.csv : 0.58 %
nad.csv : 0.57 %
amyloidosis.csv : 0.57 %
sirt3.csv : 0.55 %
sod2.csv : 0.55 %
nqo1.csv : 0.54 %
cyp1b1.csv : 0.53 %
redox_regulation.csv : 0.52 %
gnmt.csv : 0.51 %
inositol.csv : 0.50 %
mast_cell_activation.csv : 0.48 %
oxidative_protein_folding.csv : 0.47 %
heat_shock_protein.csv : 0.45 %
nr3c1.csv : 0.45 %
neuroinflammation.csv : 0.45 %
glutathione_stransferase.csv : 0.44 %
lactic_acidosis.csv : 0.43 %
glycosylation.csv : 0.43 %
glucocorticoid_receptor.csv : 0.43 %
chaperones.csv : 0.43 %
peroxiredoxin.csv : 0.42 %
gluten.csv : 0.41 %
d-limonene.csv : 0.41 %
prpc.csv : 0.41 %
sirt1.csv : 0.41 %
inflammatory_response.csv : 0.41 %
inducible_nos.csv : 0.40 %
hsp70.csv : 0.40 %
acetylation.csv : 0.39 %
gut.csv : 0.39 %
phosphatidylserine.csv : 0.38 %
mitochondrial_dysfunction.csv : 0.38 %
pyrogen.csv : 0.37 %
insp3.csv : 0.37 %
mcp-1.csv : 0.36 %
ros.csv : 0.36 %
hmgb1.csv : 0.34 %
nrf2.csv : 0.33 %
amyloid.csv : 0.33 %
adrenal_insufficiency.csv : 0.33 %
bdnf.csv : 0.33 %
curcumin.csv : 0.33 %
n-acetylglucosamine.csv : 0.32 %
glycolysis.csv : 0.31 %
resveratrol.csv : 0.31 %
nox4.csv : 0.31 %
crohns_disease.csv : 0.31 %
cfs.csv : 0.30 %
rar.csv : 0.30 %
acetylcholine.csv : 0.30 %
human_proteinuria.csv : 0.29 %
pdi.csv : 0.29 %
nac.csv : 0.29 %
urea_cycle.csv : 0.28 %
microglia.csv : 0.28 %
insulin_resistance.csv : 0.27 %
conjugation.csv : 0.27 %
cofactor.csv : 0.27 %
serca.csv : 0.27 %
csad.csv : 0.26 %
reactive_metabolites.csv : 0.26 %
mthfr.csv : 0.26 %
ngf.csv : 0.26 %
hepatocytes.csv : 0.26 %
sod3.csv : 0.26 %
disulfide_bonds.csv : 0.26 %
dim.csv : 0.26 %
liver_disease.csv : 0.26 %
phospholipid_human.csv : 0.25 %
hsc.csv : 0.25 %
fad.csv : 0.24 %
solute_carrier.csv : 0.24 %
sirt2.csv : 0.24 %
lithium_treatment.csv : 0.24 %
protease_inhibitor.csv : 0.23 %
reactive_intermediates.csv : 0.23 %
endothelial_nos.csv : 0.23 %
sinusitis.csv : 0.23 %
glutamine.csv : 0.23 %
glucose-6-phosphatase.csv : 0.23 %
butyrate.csv : 0.23 %
nadh_dehydrogenase.csv : 0.22 %
redox_potential.csv : 0.22 %
ptp1b.csv : 0.22 %
freet3.csv : 0.22 %
cholestasis.csv : 0.22 %
cyp1a1.csv : 0.22 %
flavoprotein.csv : 0.21 %
calcium_homeostasis.csv : 0.21 %
isotretinoin.csv : 0.21 %
misfolded_proteins.csv : 0.21 %
vitamin_d3.csv : 0.21 %
oxidative_stress_markers.csv : 0.20 %
detoxification.csv : 0.20 %
esr1.csv : 0.20 %
cox-2.csv : 0.20 %
ckd.csv : 0.20 %
pomc.csv : 0.20 %
udpglcnac.csv : 0.19 %
choline_deficiency.csv : 0.19 %
l-cysteine.csv : 0.19 %
astrocytes.csv : 0.19 %
neurite_outgrowth.csv : 0.19 %
nadph.csv : 0.19 %
nachr.csv : 0.19 %
sod1.csv : 0.18 %
caloric_restriction.csv : 0.18 %
hexosamine.csv : 0.18 %
biotin.csv : 0.18 %
oxidative_stress_protection.csv : 0.18 %
coenzymeq10.csv : 0.18 %
cortisol.csv : 0.18 %
cyp2e1.csv : 0.17 %
h2o2.csv : 0.17 %
ppp.csv : 0.17 %
gsh.csv : 0.17 %
lipoic_acid.csv : 0.17 %
sulfotransferase.csv : 0.16 %
gtp_cyclohydrolase.csv : 0.16 %
quinone_reductase.csv : 0.16 %
liver_injury.csv : 0.16 %
sarcosine.csv : 0.16 %
advanced_glycation_end.csv : 0.16 %
sulforaphane.csv : 0.16 %
sulfite_oxidase.csv : 0.16 %
microbiome_humans.csv : 0.16 %
glutamate.csv : 0.16 %
probiotics.csv : 0.15 %
tau.csv : 0.15 %
hepatotoxicity.csv : 0.15 %
adrenergic_receptor.csv : 0.14 %
testosterone_production.csv : 0.14 %
fmo3.csv : 0.13 %
l-arginine.csv : 0.13 %
hba1c.csv : 0.13 %
tbars.csv : 0.13 %
methionine.csv : 0.13 %
cyp1a2.csv : 0.13 %
catalase.csv : 0.13 %
adrenal_hyperplasia.csv : 0.13 %
hgh.csv : 0.12 %
l_tyrosine.csv : 0.12 %
cyp2d6.csv : 0.12 %
subclinicalhypo.csv : 0.12 %
rxr.csv : 0.12 %
trpv.csv : 0.12 %
omega3.csv : 0.12 %
glycerylphosphorylcholine.csv : 0.12 %
n-acetyltransferase.csv : 0.11 %
constipation.csv : 0.11 %
dolichol.csv : 0.11 %
choline.csv : 0.11 %
pyruvate_carboxylase.csv : 0.11 %
ggt.csv : 0.11 %
cortisol_levels.csv : 0.11 %
zinc_supplementation.csv : 0.11 %
xanthine_oxidase.csv : 0.11 %
p450.csv : 0.11 %
excitotoxicity.csv : 0.10 %
dht.csv : 0.10 %
ugt1a1.csv : 0.10 %
bilirubin.csv : 0.10 %
steatohepatitis.csv : 0.10 %
erad.csv : 0.10 %
dhea.csv : 0.10 %
exercise_intolerance.csv : 0.10 %
are.csv : 0.10 %
cimetidine.csv : 0.10 %
dihydroprogesterone.csv : 0.10 %
selenium.csv : 0.09 %
tetrahydrobiopterin.csv : 0.09 %
l_tryptophan.csv : 0.09 %
hydrogen_sulfide.csv : 0.09 %
phospholamban.csv : 0.09 %
phosphatidylcholine.csv : 0.09 %
hydroxysteroid_dehydrogenase.csv : 0.09 %
acetyl-coa.csv : 0.09 %
redox_cofactor.csv : 0.09 %
peroxynitrite.csv : 0.09 %
triiodothyronine_levels.csv : 0.08 %
hpa_axis.csv : 0.08 %
anhedonia.csv : 0.08 %
histamine.csv : 0.08 %
sulfation.csv : 0.08 %
p5p.csv : 0.08 %
uric_acid.csv : 0.08 %
nafld.csv : 0.08 %
pxr.csv : 0.08 %
acetyl_coa_carboxylase.csv : 0.08 %
nmda.csv : 0.07 %
isoprostane.csv : 0.07 %
p450oxidoreductase.csv : 0.07 %
cannabidiol.csv : 0.07 %
irritable_bowel.csv : 0.07 %
beta-alanine.csv : 0.07 %
monosodium_glutamate.csv : 0.07 %
uti.csv : 0.07 %
hmgcoa.csv : 0.07 %
oxidation.csv : 0.07 %
kainate.csv : 0.07 %
riboflavin.csv : 0.06 %
gaba_human.csv : 0.06 %
iron_deficiency.csv : 0.06 %
creatine_supplementation.csv : 0.06 %
angiotensin_human.csv : 0.06 %
l_carnitine.csv : 0.06 %
d_serine.csv : 0.06 %
human_semen.csv : 0.06 %
hypobaric_hypoxia.csv : 0.06 %
ginkgo.csv : 0.06 %
ampa.csv : 0.06 %
nitration.csv : 0.05 %
molybdenum.csv : 0.05 %
neuronal_nos.csv : 0.05 %
vitamin_k.csv : 0.05 %
ed.csv : 0.05 %
liver_regeneration.csv : 0.05 %
sulfur.csv : 0.05 %
5alphareductase.csv : 0.05 %
enterohepatic_circulation.csv : 0.05 %
cyp3a4.csv : 0.05 %
norepinephrine.csv : 0.05 %
fluoroquinolone.csv : 0.05 %
urolithiasis.csv : 0.05 %
serotonin_levels.csv : 0.05 %
pregnenolone.csv : 0.04 %
asymmetric_dimethylarginine.csv : 0.04 %
sshl.csv : 0.04 %
dopamine.csv : 0.04 %
finasteride.csv : 0.04 %
dysautonomia.csv : 0.04 %
monoamine_oxidase.csv : 0.04 %
5-htp.csv : 0.04 %
niacin.csv : 0.04 %
l-dopa.csv : 0.04 %
hyperammonemia.csv : 0.03 %
sleep_apnea.csv : 0.03 %
fmn.csv : 0.03 %
taurine.csv : 0.03 %
atrial_fibrillation.csv : 0.03 %
panic_disorder.csv : 0.03 %
ciprofloxacin.csv : 0.03 %
autism.csv : 0.03 %
selenium_deficiency.csv : 0.03 %
hydrolysis.csv : 0.03 %
steroidogenesis_human.csv : 0.02 %
magnesium_deficiency.csv : 0.02 %
3betahsd.csv : 0.02 %
insomnia.csv : 0.02 %
lpa.csv : 0.02 %
glucuronidation.csv : 0.02 %
tinnitus.csv : 0.02 %
thermoregulation.csv : 0.02 %
bradycardia.csv : 0.02 %
5-ht2.csv : 0.02 %
limbic_system.csv : 0.02 %
peristalsis.csv : 0.02 %
udpgluc.csv : 0.02 %
orthostatic_intolerance.csv : 0.01 %
thiamine.csv : 0.01 %
baroreceptor.csv : 0.01 %
oxalates.csv : 0.01 %
bile_acid.csv : 0.01 %
social_anxiety.csv : 0.01 %
adhd.csv : 0.00 %
artichoke.csv : 0.00 %
cyp7a1.csv : 0.00 %
car.csv : 0.00 %
vitamin_b6.csv : 0.00 %
akr1d1.csv : 0.00 %
star.csv : 0.00 %
p450scc.csv : 0.00 %
pantothenic_acid.csv : 0.00 %
cysteine_desulfurase.csv : 0.00 %
ae2.csv : 0.00 %
ndufs7.csv : 0.00 %
dpagt1.csv : 0.00 %
phenylketonuria.csv : 0.00 %
pqq.csv : 0.00 %
mucuna.csv : 0.00 %
fads1.csv : 0.00 %
allopregnanolone.csv : 0.00 %
fxr.csv : 0.00 %
sult2a1.csv : 0.00 %
3methylcrotonyl_coa_carboxylase.csv : 0.00 %
cyp27a1.csv : 0.00 %
pgc1.csv : 0.00 %
intestinal_motility.csv : 0.00 %
d_aminoacid_oxidase.csv : 0.00 %
cerebrovascular_amyloidosis.csv : 0.00 %
hnmt.csv : 0.00 %
benfotiamine.csv : 0.00 %
cyp8b1.csv : 0.00 %
ugt1a9.csv : 0.00 %
scfa.csv : 0.00 %
srd5a3.csv : 0.00 %
tudca.csv : 0.00 %
potassium_levels.csv : 0.00 %
propionyl_coa_carboxylase.csv : 0.00 %
rls.csv : 0.00 %
ero1.csv : 0.00 %
gilberts.csv : 0.00 %
tocotrienol.csv : 0.00 %
resistant_starch.csv : 0.00 %
fads2.csv : 0.00 %
osmolytes.csv : 0.00 %
pantethine.csv : 0.00 %
tmao.csv : 0.00 %
@Tunguska
First things first :
1) The fact that i don't have a sufficient amount of cases (=their DNA Data) of People that do not have CFS/PFS/Accutane/..//.. Syndromes is a serious limitation.
2) Even if that Data existed, there are so many other factors (Gender, Age, Environment, etc etc) that further make things even more difficult.
3) To make things even worse, there are so many genes involved with the Topics that are being discussed in this Thread.
A couple of things that i don't know about you (if possible please send them as a PM) :
1) How did you get CFS?
2) When you say "i have multiple" what do you mean? You have CFS *and* Post-Lyme Disease *and* PFS ...??
3) How are your P450 CYPs according to Nutrahacker?
Some notes regarding the Alleles you sent me :
1. I would like to first point your attention to your ATF6 Alleles: One homozygous to ATF6, 1 hetero to ATF6. Then you have 1 homozygous to Cholestasis, several to NOS2, Several to Sulfation, several to NR3C1. Finally homozygous to NFE2L2 aka NRF2. Did you see NRF2 and ATF6 towards the top of the list on the snapshot of the Data Mining tool ?
2. Of course this (= the alleles) may not mean a thing. There may be so many others here that do not have -say- ATF6 alleles and NRF2 alleles and yet they have CFS. What i am trying to say is : Try to see the Big picture. There are several holes in the Redox system : Choline, Methylation, Sulfation, Glucuronidation, ER Stress Response, P450 CYPs activity, Redox co-factors, etc, etc. ..and ALL of these paint the Big Picture.
Regarding Choline i do not know what is best unfortunately.
@Tunguska I am willing to work with you. So if you want to give this a chance let's go for it. Then you will be able to say exactly what happened to all members of the Forum.
Let me know what you think.
Many “blockbuster” therapeutic proteins in the market are antibodies, which are N-linked glycoproteins. For example, Etanercept, Infliximab and Rituximab are N-glycosylated therapeutic proteins.
The importance of N-linked glycosylation is becoming increasingly evident in the field of pharmaceuticals.
Endoplasmic-reticulum-associated protein degradation (ERAD) designates a cellular pathway which targets misfolded proteins of the endoplasmic reticulum for ubiquitination and subsequent degradation by a protein-degrading complex, called the proteasome.
Endoplasmic reticulum HSP90b1 (gp96, grp94) optimizes B-cell function via chaperoning integrin and TLR but not immunoglobulin.
Liu B1, Li Z.
Author information
Abstract
- 1Department of Immunology, Center for Immunotherapy of Cancer and Infectious Diseases, Neag Comprehensive Cancer Center, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA.
Endoplasmic reticulum (ER) unfolded protein response (UPR) plays pivotal roles in both early B-cell development and plasma cell differentiation. As a major ER chaperone to mediate the UPR and a master chaperone for Toll-like receptors (TLRs), HSP90b1 (grp94, gp96) has long been implicated to facilitate the assembly of immunoglobulin. We hereby critically and comprehensively examine the roles of HSP90b1 in B-cell biology in vivo using B-cell-specific HSP90b1-null mice. We found that knockout B cells developed normally. There were no apparent problems with plasma cell differentiation, Ig assembly, class-switching, and Ig production. Strikingly, although both mutant conventional and innatelike B cells failed to compartmentalize properly due to loss of select but not all integrins, HSP90b1 was required for neither germinal center formation nor memory antibody responses in vivo. The only significant defect associated with HSP90b1 ablation in B cells was an attenuated antibody production in the context of TLR stimulation. Thus, our study has resolved the long-standing question regarding HSP90b1 in B-cell biology: HSP90b1 optimizes the function of B cells by chaperoning TLRs and integrins but not immunoglobulin. This study also has important implications in resolving the controversial roles of TLR in B-cell biology.
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system. They are single, membrane-spanning, non-catalytic receptors usually expressed insentinel cells such as macrophages and dendritic cells, that recognize structurally conserved molecules derived from microbes. Once these microbes have breached physical barriers such as the skin or intestinal tractmucosa, they are recognized by TLRs, which activate immune cell responses. The TLRs include TLR1, TLR2, TLR3, TLR4, TLR5, TLR6, TLR7, TLR8,TLR9, TLR10, TLR11, TLR12, and TLR13, though the latter three are not found in humans.
It is interesting to note that PrxIV is upregulated dramatically in line with ER oxidoreductases as the ER expands during B-cell differentiation to ensure efficient synthesis of immunoglobulins (van Anken et al., 2003). However, PrxIV does not seem to be induced during the UPR (Tavender et al., 2008). It could be that during differentiation, levels of PrxIV need to increase to accommodate the increased load of disulphide formation, but during UPR, levels need to remain constant to allow signalling of oxidative stress. Clearly, more work is needed to clarify this point.
@Violeta
I do not see how the things you are discussing are connected with 5-Alpha Reductase unfortunately
@Violeta
I do not see how the things you are discussing are connected with 5-Alpha Reductase unfortunately
I don't have a Nutrahacker report. Risk alleles: genetic genie results?Can you send over the PDF with the Risk Alleles that you have? Could you also send over your Nutrahacker report regarding your P450 CYPs?
I don't have a Nutrahacker report. Risk alleles: genetic genie results?