Hi,
I really need help understanding what is happening to me.
Ever since taking a B-complex with folic acid, it looks like I have a methylation block. I developed food intolerances, constant burping, histamine intolerance, and a complete worsening of my condition.
Ran a few tests and this is what it revealed:
- vitamin B6 is 3x too high (I assume because it doesn't get converted to P5P)
- vitamin B5 and folic acid are a bit high
- I have gut issues
- H pylori
- SIBO
- most likely leaky gut (because of lack of beneficial leakygut strains)
- Heterozygous MTHFR C667T mutation
- Various heteorzygous histamine related mutations (HNMT, AOC1/ABP1)
In the next few days I will also be tested for pyroluria and holotranscobalamin (to see if I have a functional B12 deficiency).
QUESTIONS
1) Is it possible I'm suffering from a methyltrap? Would this be confirmed by a low holotranscobalamin result?
2) I read that I must treat the gut first. However, B12 deficiencies can lead to permanent nerve damage (and I have severe ear problems): is there any danger to staying in a methylation block for too long, especially regarding B12? It's been 6 months, I feel like I would like to kickstart methylation as soon as possible but I read everywhere it's gut first.
Thank you very much, I am completely lost
I really need help understanding what is happening to me.
Ever since taking a B-complex with folic acid, it looks like I have a methylation block. I developed food intolerances, constant burping, histamine intolerance, and a complete worsening of my condition.
Ran a few tests and this is what it revealed:
- vitamin B6 is 3x too high (I assume because it doesn't get converted to P5P)
- vitamin B5 and folic acid are a bit high
- I have gut issues
- H pylori
- SIBO
- most likely leaky gut (because of lack of beneficial leakygut strains)
- Heterozygous MTHFR C667T mutation
- Various heteorzygous histamine related mutations (HNMT, AOC1/ABP1)
In the next few days I will also be tested for pyroluria and holotranscobalamin (to see if I have a functional B12 deficiency).
QUESTIONS
1) Is it possible I'm suffering from a methyltrap? Would this be confirmed by a low holotranscobalamin result?
2) I read that I must treat the gut first. However, B12 deficiencies can lead to permanent nerve damage (and I have severe ear problems): is there any danger to staying in a methylation block for too long, especially regarding B12? It's been 6 months, I feel like I would like to kickstart methylation as soon as possible but I read everywhere it's gut first.
Thank you very much, I am completely lost
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