@alicec @CCC In fact, once I got as high as 7-8,000mcg of folate the runny nose did go away (I'm hovering at about 5,000 for the moment). This runny nose, which I've had for over two years--on and off--is literally a slow drip, like from a leaky faucet, and only from my left nostril! Not very viscous, and thus, for me, not really like a cold. Also, there are no accompanying sinus symptoms, twinges, pressure, aches. As you note, the red-rimmed eyes seem to be a secondary symptom for me, an increase of the folate demand, though I also think of it as a higher need for Adenosyl B12 with its antioxidant qualities.
There were times this symptom and others such as the Dupytrens pain would oddly dissipate or be less insistent when I was working on other supps, say ramping up the B2, etc. It was as if they were taking a back seat. But then, last October, the results of a second NutrEval test in a little over a year showed a marked decline in many of the Bs, and especially B12 and Folate. And in a new marker for methylation, mine was in the red, for High Need. Not good. So I moved forward accordingly. Strangely,as I began to work directly with the folate, and was able to ramp up in ways I hadn't been able to before (not enough molybdenum,say, or selenium, or perhaps functioning B2) then my symptoms with each addition would briefly worsen,as Fred describes in the 'Refeeding' thread.
And yes, some symptoms are certainly folate need, or as I mentioned yesterday, a paradoxical folate need where what you actually need is the B12 in the cells so the folate isn't blocked. If it's later in the day, away from my morning oil squirt or squirts-- still experimenting here--and I am exhausted, say, then it is probably the B12 I need. At night or early morning tingling in my extremities is B12.
But then, the two definitely work together. Greg always says the B12 'recycles' the folate and when that is working, and when your tanks are full, you won't need as much folate. There are certainly folks here who have gotten to that point. I'm not one of them!
Two things: I really wish I understood more of the science, and I am very leery of terming anything 'detox' as I had a very bad experience with this many years ago. It was definitely NOT detox, I needed electrolytes...