sometexan84
Senior Member
- Messages
- 1,242
Overwhelmed by all of the hypotheses out there? Well so am I.
IDO Metabolic Trap (Robert Phair)
Inhibition of IDO1 creates the possibility of metabolic bistability in cells expressing the kynurenine pathway
Vagus Nerve Hypothesis (Michael VanElzakker)
In some individuals, the symptoms of chronic fatigue syndrome (CFS) are caused by an infection in or around the vagus nerve
Viral Cardiomyopathy (Martin Lerner)
CFS is a persistent nonpermissive herpes virus infection of the heart
Cell Danger Response (Robert Naviaux)
A hypometabolic survival state that is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis
Enteroviral infection hypothesis (John Chia, Byron Hyde, Melvin Ramsay)
A significant subset of patients had their illness triggered by an enterovirus, one that might continue to persist and contribute to symptoms
Ken Lassesen's "gut" model (Ken Lassesen)
CFS is caused by a stable dysfunction of the gut microbiome
Methylation cycle (Rich Van Konynenburg)
A core component of the pathophysiology of chronic fatigue syndrome involves a partial block in the methylation cycle
Nitric oxide hypothesis (NO/ONOO cycle) (Martin Pall)
Viral or bacterial infection induces one or more cytokines that lead to increased nitric oxide levels, which react with superoxide radicals to generate the potent oxidant peroxynitrite
Nitrogen metabolism (Christopher Armstrong)
Nitrogen-containing by-products of energy production accumulate more readily in the cells of people with ME / CFS, damaging the cells and their process of producing energy
Omega 3 fatty acid (Basant Puri)
ME/CFS symptoms due to abnormal production of eicosanoids, signaling molecules involved in inflammation that are produced from fatty acids found in cell membranes
RCCX Theory (Sharon Meglathery)
Co-inheritance of the highly mutable genes of the RCCX module may confer vulnerability to familial clusters of overlapping syndromes of chronic illness (hyper-mobility, autoimmune disease, CFS/ME, MCAS, POTS, and 80% of Psychiatric and neurodevelopmental disorders)
Mackay-Tate hypothalamus hypothesis (Mackay A, Tate WP)
Neuroinflammation causing dysfunction of the limbic system and its hypothalamus together with a consequently disrupted autonomic nervous system
B2 adrenergic receptor dysfunction (Klaus Wirth, Carmen Scheibenbogen)
An autoimmune process attacking the B2 adrenergic receptor
Hypercoagulation theory (David Berg, Joseph Brewer)
An infection causing excessive coagulation (due to a genetic or an acquired coagulation defect), where the immune system is unable to effectively fight.
Cortene's hypothesis (Lucinda Bateman, Cortene inc)
Upregulation of CRF2 in the limbic system deregulates serotonin, norepinephrine (and other neurotransmitters) and cortisol, leading to wide-ranging dysfunction.
IDO Metabolic Trap (Robert Phair)
Inhibition of IDO1 creates the possibility of metabolic bistability in cells expressing the kynurenine pathway
Vagus Nerve Hypothesis (Michael VanElzakker)
In some individuals, the symptoms of chronic fatigue syndrome (CFS) are caused by an infection in or around the vagus nerve
Viral Cardiomyopathy (Martin Lerner)
CFS is a persistent nonpermissive herpes virus infection of the heart
Cell Danger Response (Robert Naviaux)
A hypometabolic survival state that is triggered by encounters with chemical, physical, or biological threats that exceed the cellular capacity for homeostasis
Enteroviral infection hypothesis (John Chia, Byron Hyde, Melvin Ramsay)
A significant subset of patients had their illness triggered by an enterovirus, one that might continue to persist and contribute to symptoms
Ken Lassesen's "gut" model (Ken Lassesen)
CFS is caused by a stable dysfunction of the gut microbiome
Methylation cycle (Rich Van Konynenburg)
A core component of the pathophysiology of chronic fatigue syndrome involves a partial block in the methylation cycle
Nitric oxide hypothesis (NO/ONOO cycle) (Martin Pall)
Viral or bacterial infection induces one or more cytokines that lead to increased nitric oxide levels, which react with superoxide radicals to generate the potent oxidant peroxynitrite
Nitrogen metabolism (Christopher Armstrong)
Nitrogen-containing by-products of energy production accumulate more readily in the cells of people with ME / CFS, damaging the cells and their process of producing energy
Omega 3 fatty acid (Basant Puri)
ME/CFS symptoms due to abnormal production of eicosanoids, signaling molecules involved in inflammation that are produced from fatty acids found in cell membranes
RCCX Theory (Sharon Meglathery)
Co-inheritance of the highly mutable genes of the RCCX module may confer vulnerability to familial clusters of overlapping syndromes of chronic illness (hyper-mobility, autoimmune disease, CFS/ME, MCAS, POTS, and 80% of Psychiatric and neurodevelopmental disorders)
Mackay-Tate hypothalamus hypothesis (Mackay A, Tate WP)
Neuroinflammation causing dysfunction of the limbic system and its hypothalamus together with a consequently disrupted autonomic nervous system
B2 adrenergic receptor dysfunction (Klaus Wirth, Carmen Scheibenbogen)
An autoimmune process attacking the B2 adrenergic receptor
Hypercoagulation theory (David Berg, Joseph Brewer)
An infection causing excessive coagulation (due to a genetic or an acquired coagulation defect), where the immune system is unable to effectively fight.
Cortene's hypothesis (Lucinda Bateman, Cortene inc)
Upregulation of CRF2 in the limbic system deregulates serotonin, norepinephrine (and other neurotransmitters) and cortisol, leading to wide-ranging dysfunction.
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