Thanks for this @snowman
. Great info and analysis in your post and it concurs very much with my experience i.e. of polyglandular dysfunction - however, not a single antibody found (except for low coeliac antibody) over years and years of antibody blood tests. And even then, I often wonder if the gut biopsy was showing some atrophy in the lining from b12 deficiency and not coeliac disease. I'm gluten-free anyway, just in case.
Anyhow, since the high-dose methylation supplements, the ovary function (which was indeed more or less dormant) is returning, though haphazardly thus far (better than nothing), and the thyroid is certainly improving the last four days - since reintroducing some t4 in the form of Erfa NDT (only 2 grains so hopefully not too much t4, as you say), I'm no longer icy..
The reason I went on t3-only is that, just as you say, I came to the conclusion, (after countless hours of reading thyroid papers, sites, and forums) that I had a transporter problem of some kind - I guessed it might be a reverse t3 (rt3) issue (though I never got it tested because test was refused - endocrinologist didn't believe in it) and when I made the decision to try t3- only to avoid any possible conversion issues, I did quite well on t3 only for a good while. But perhaps I should have switched back to including some t4 sooner.
About the adrenal side of things (and I'm detailing it all, as you have done, just in case anybody else benefits) I have needed hydrocortisone for almost two years now (plus iron at times) to support them, even to enable small doses of thyroid meds. But, I have now managed to slightly lower my hydrocortisone 20mg to 18mg over the last few weeks since methylation protocol and will try reducing by 2mg every few weeks and see how I go. I feel I have too much cortisol at times now, especially in the evenings and night time - big energy surge, just when I want to sleep. Thankfully I no longer have incapacitating weakness in the mornings anymore, though it does still take a few hours to get the energy going. And I do still have to work on the circadian rhythm disruption. But I'm delighted to be sleeping at least 6 hours without a break (even though it's still at the wrong times. Before, I was getting 3 hours straight, sometimes less).
I can't believe the amount I've been able to do in the last few weeks - yesterday again, a long gentle walk and coffee with my husband (he's utterly stunned at me being able to this) and then I made dinner when we got home. (Ok, I did get painful pins & needles in my feet and suddenly horribly achy and sweaty at the end all this), but I took some extra mfolate and mb12 and I'm okay again today, if not quite as energetic - nothing like as weak and disabled as I used to be after even 10 minutes washing-up. I really will have to go easy though. I can see how easily it would be to crash again.
Thats' really interesting about FMN - I must look into that more...and I'm sure I'm not home free just yet...
I'm hoping that if there was any immune-function issue that it will settle now that the body has what it needs to take care of itself. It's no wonder the immune system misdirects itself and creates antibodies, in starving bodies that are unable to fight pathogens normally...
I hope my experience so far will be of some help.
The main thing that helped (and helped dramatically) was jumping up from low-dose mb12 and mfolate, but I do plan to reduce eventually. For one thing, it would be too expensive to continue.
B12oils might be an option. You mentioned the B12oils guy. He believes the ME methylation issue is due to a lack of b12 plus B2, not just b12. He's called Dr Gary Russell-Jones (biochemist with 25 years of b12 speciality apparently), and there's a good thread on him and his oils here, if you want to read how others got on: