Thymus infection in mice with virus related to HHV-6 triggers autoimmunity by impeding deletion of self-reactive T-cells

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A study in mice found that when mouse roseolovirus infects the thymus gland, it thwarts the ability of the thymus to remove self-reactive T-cells — the T-cells that can cause autoimmunity.

Mouse roseolovirus is closely-related to human HHV-6 and HHV-7, so the implication is that these herpesviruses could be inducing autoimmunity in humans.

The researchers want to see if the same thing happens in humans, but they state it is hard to determine if viruses like HHV-6 are causing autoimmunity in people, because almost everyone has HHV-6.


Article: New way viruses trigger autoimmunity discovered

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