Thermoregulation and body temperature

borko2100

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I have the opposite problem, namely feeling hot / overheating. This symptom only occurs at a certain time of day - usually around evening time (+- 10 hours after waking up). To describe it simply, around evening time I start feeling as if the room has suddenly become several degrees hotter, while in reality nothing has changed (I have checked with a room thermometer).

Finally, this symptom seems to be made much worse if I am in a crash / PEM. I remember, during a recent crash, feeling that way for the majority of the day and waking up feeling very hot and warmed up (interestingly without any signs of sweating at night).

As far as feeling cold is concerned, I do not notice such a feeling at normal room temperature, with the exception of my feet, those feel quite cold indeed. On the other hand if I am outside often times I can not tolerate the cold (5 C or below) and I do start shivering quite severely, while other people around me seem be doing just fine.
 

HTester

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I sweat excessively when I go out in the sun for even a few minutes.
Your post is important to my thinking; thanks for investing the time to write it. Do I understand correctly that even though you sweat profusely, you do not flush? By flushing I mean that your skin changes color towards red, which is one of the normal physiological responses to high core body temperature. The mechanism of this response is autonomic vasodilation of skin arterioles with the teleological goal of radiating heat away from your body. It would be an important hint about ME/CFS if your body is sweating but not flushing.
 

raghav

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@HTester Yes. You are correct. I sweat a lot yet no flushing. I need an external source of coolant to cool my body. I did not have this feeling of heat intolerance when I was on Deanxit (Flupentixol + Melitracen). Now I use only Flupentixol for my IBS. Melitracen was regulating body temperature. It is a tricyclic antidepressant. Not much literature is available in the western world since it was never approved in US. It is make by Lundbeck Pharma.
 

JadeD

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@HTester - I’m the same as @raghav, I sweat excessively on a daily basis but do not flush/go red. The hot flush I described in an earlier post was actually me describing the sensation of feeling like I’m internally burning up/hot a bit like how you feel when you are feverish. But I don’t visibly flush, my extremities can still be vasoconstricted and ice cold throughout.
 

HTester

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I sweat a lot yet no flushing.
I sweat excessively on a daily basis but do not flush/go red.
I remember another thread somewhere on PR in which patients describe freezing cold extremities while at the same time another part of their body is sweating. What you both describe is actually very closely related. All of these cases have one autonomic effector system responding as if to high temperature and another responding as if to low temperature, simultaneously. It seems unlikely that all the different afferent dorsal horn pathways are sending wrong signals to the hypothalamus. More likely is that some efferent pathways are being inappropriately inhibited and others not. In the rat, this control point is in the rostral medullary raphe. I'll have to find out where that control region is in the human brain. There's also the question of how you can sweat without flushing since both are mediated, at least in part, by vasodilation. I'll look into that too. This feels like a productive line of investigation. Thanks.
 

perrier

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I remember another thread somewhere on PR in which patients describe freezing cold extremities while at the same time another part of their body is sweating. What you both describe is actually very closely related. All of these cases have one autonomic effector system responding as if to high temperature and another responding as if to low temperature, simultaneously. It seems unlikely that all the different afferent dorsal horn pathways are sending wrong signals to the hypothalamus. More likely is that some efferent pathways are being inappropriately inhibited and others not. In the rat, this control point is in the rostral medullary raphe. I'll have to find out where that control region is in the human brain. There's also the question of how you can sweat without flushing since both are mediated, at least in part, by vasodilation. I'll look into that too. This feels like a productive line of investigation. Thanks.
Interesting Dr Phair what you raise: simultaneously one part of the body cold and another part hot/sweating. This is exactly what happens to our family member. Her hands and feet and nose are ice cold virtually always, except in our brief Canadian summer. Yet, even in the middle of a Canadian winter in the house she wears sleeveless shirts or summer blouses because she says she sweats--while her feet and hands are ice cold. (I on the other hand always wear sweaters in the house in winter.). She never seems to feel a comfortable temperature, ever, except in the bath tub.
 
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She often complains that the cold is " inside", in her bones
I just thought I would comment that I experience- very deep "cold" that parks inside deep joints- it feels: well very cold.

I do chinese Traditional Medicine and that "cold" is "wind"....inside the joint. So when I go on wind reducing diet, or use herbs to reduce wind, this 'cold" phenomenon...goes away.

This is "different" from- your body temperature overall- it feels like a dense pit of cold deep inside a specific spot.

I fell and turned by ankle sideways quite severely. After a few days, that shifted and this incredible cold parked in my ankle- I used herbs to dissipate it. (soaking).