I was diagnosed as having CFS in 1993 in Australia.I didn't have a medical or scientific background so I decided to start from scratch ,reading textbooks and then journals.It seemed clear to me that undiagnosed liver damage is my health problem because I had the symptoms of cholestasis while taking medication known to cause cholestasis(nausea anorexia malaise altough it is worse than it sounds),severe fatigue is the main symptom of cholestasis and it affects the part of the liver where xenobiotic chemicals are detoxified(I am intolerant to chemicals.)
I don't remember exactly why I looked at EBV and the liver.Maybe after reading a blog by a CFS sufferer I decided to check if EBV affects the liver because I remember that in an article by Jules Dienstag Non-A,Non-B Hepatitis Gastroenterology 1983;85(I don't have the page number in front of me)there is a list of viruses that can cause liver disease and so I came across the abstract of the study by David H Adams.
I have also read somewhere that endotoxin can cause cholestasis(could it be because it is excreted in the bile?)Justin30 posted Endotoxin and Vitamin C Part1-Sepsis,Endotoxin and Vitamin C Archie Kalokerinos J Aust Coll Nutr & Env Med Vol 24 No 1 (April 2005)pages 17-21(it was a thread about Low T,high? and DHEA).
I understand that those in the same situation as myself are a minority,I am trying to find out about the symptoms and different pathologies of other fellow ME/CFS sufferers,I think that those that suffer from Glutathione Depletion-Methylation Cycle Block might also have difficulty eliminating chemicals so a study or a diagnosting test in the basis of the speed at which we eliminate chemicals would probably work for 2 subsets of patients since blood tests are unreliable when it comes to diagnosing liver damage that has already occured(although we might probably use different alternative metabolic pathways the one that synthesizes prostaglandins is most likely the alternative to Cytochrome P450enzymes-I don't know what happens to those who have glutathione depletion,they probably accumulate metabolites or is there an alternative metabolic pathway as well?)
If you want to know more about my symptoms or references from medical journals or anything else let me know.I am struggling to keep up with the information on research that is posted on forums,I don't think I ''ll be able to keep this up for very long even though I find the bits that I understand fascinating.
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