I am thinking this one needs to be looked at closer..... ABP1rs35070995 150557707 A A for me at least... but I really don't understand it so just a guess... I can think sometimes but not all the time... brain fog progresses to something more solid some day more like brain mush.
Feedback or knowledge shared on my situation is welcomed.
talks of the ABP1 histamine breakdown genes but also HNMT and lists the snps
"HNMT produces the enzyme that uses a methyl group to degrade histamine in the body. The ABP1 gene also clears histamine with the DAO enzyme. If there are many SNPs, and low methyl groups, there is the potential for high histamine. This can result in high levels of zonulin, which can cause gut inflammation and the potential for leaky gut. Over time, this may contribute to autoimmune disorders. Avoiding high histamine foods (alcoholic beverages and fermented foods) may be helpful as well as taking high amounts of Histamine Scavenger. Sometimes dosages need to be 9 to 12 per day in the beginning, and then can reduce over time. Histamine Scavenger may need Pro SAMe if there are low methyl groups. If there is a lot of histamin"
edit to put in the quotes obvious to me but maybe not to others these are not my words
A lot of other things are covered bit much for me just now hope it is useful to some people here.
The cytochrome P450s (CYPs) are a superfamily of heme-containing mixed function oxygenases that catalyse the regio- and stereo-selective oxidation of a wide variety of xenobiotics including drugs. While in vitro high throughput screenings using hepatocytes and microsomes are routinely conducted in drug discovery settings, summarized information on drug metabolisms can also be obtained from public literatures. The present study was initiated to develop a natural language processing system specializing in extracting information on CYP-drug interactions. This system utilizes an open-source language processing system GATE, implementing the rules that identify chemical names and extract CYP-drug interaction information in a context-based manner, together with a chemical name dictionary (>100,000 compounds registered). Information extraction was performed by the following steps: identification of chemical and CYP names in the text, transformation of sentences into multiple simple clauses implying each single event, and pattern matching of keyword sequences within the clauses, where the compounds were categorized in substrates, inhibitors, and inducers. Using PubMed database, approximately 2000 compounds names were obtained by the present system. When 100 PubMed abstracts regarding CYP3A4 were randomly selected to examine feasibility of the system, it was found that the present text mining system gave a high performance on extraction of chemical names (0.871 recall, 0.941 precision) and CYP-chemical interactions (0.852 recall, 0.920 precision). For about 1000 compounds that are registered in PubChem, structure-activity relationship analysis was conducted by an extended recursive partitioning method. The analysis revealed 1) CYP2C9 and CYP2C19 are similar in substrate specificity, 2) substrates and inhibitors for CYP2E1 are smaller in molecular size, 3) substrates for CYP2D6 and CYP3A4 are relatively larger, 4) many of CYP2D6 substrates are cationic, and 5) compounds that are not cationized at neutral do not tend to inhibit CYP2D6 activity. These trends can be intuitively understood by a large-scale data visualization technique HeiankyoView, which can represent hierarchically structured data with rectangular icons and borders.
I have an issue with one of these cyps...
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. CYP2D6 gene and think some drugs I have taken have hurt me.