The Histamine Gene rs10156191

Gingergrrl

Senior Member
Messages
15,892
Likes
47,062
How do you find this histamine gene on 23andMe through Genetic Genie? Does it have a different name? Sorry for another dumb question!
 

drob31

Senior Member
Messages
1,487
Likes
1,095
How do you find this histamine gene on 23andMe through Genetic Genie? Does it have a different name? Sorry for another dumb question!
Click on Gondwanaland's link, and log in to 23andme.com, and it will show you the SNP's for the histamine gene.
 

Gingergrrl

Senior Member
Messages
15,892
Likes
47,062
Click on Gondwanaland's link, and log in to 23andme.com, and it will show you the SNP's for the histamine gene.
Can you see it on the Genetic Genie print out? I have never logged into 23andMe and not sure what you do?
 

Gondwanaland

Senior Member
Messages
5,057
Likes
4,274
I'm CC. And on the link from @Gondwanaland, I have 11, of which 9 are homozygous. Is this the source of my histamine issues??
Apparently not - I think +/+ MAO-A is enough reason ;)
Can you see it on the Genetic Genie print out?
Nope.
I have never logged into 23andMe and not sure what you do?
Username, password, raw data, then paste rs10156191 into SNP box or ABP1 into gene box.
Easier if just clicking the link on post #4 and logging in from there.
 

Valentijn

Senior Member
Messages
15,786
Likes
45,677
rs10156191 TT is pretty common: about 10% of people have that genotype, going up to 40% in some ethnic groups. It's a bit interesting, because according to the research at http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02548.x/full it's associated with down-regulation of the gene, but not associated with histamine intolerance at all.

It would seem to suggest that the down-regulation of the AOC1 gene caused by rs10156191 TT isn't sufficient to cause any problems. It's not too uncommon for that to happen on various genes.
 

drob31

Senior Member
Messages
1,487
Likes
1,095
rs10156191 TT is pretty common: about 10% of people have that genotype, going up to 40% in some ethnic groups. It's a bit interesting, because according to the research at http://onlinelibrary.wiley.com/doi/10.1111/j.1398-9995.2011.02548.x/full it's associated with down-regulation of the gene, but not associated with histamine intolerance at all.

It would seem to suggest that the down-regulation of the AOC1 gene caused by rs10156191 TT isn't sufficient to cause any problems. It's not too uncommon for that to happen on various genes.
Thanks val. Do you base the SNP mainly on prevalence? I'm just wondering because I'm working with someone who is basing their research on the correlation with the SNP's in literature (pub med, etc), and not prevalence.
 

Valentijn

Senior Member
Messages
15,786
Likes
45,677
Thanks val. Do you base the SNP mainly on prevalence? I'm just wondering because I'm working with someone who is basing their research on the correlation with the SNP's in literature (pub med, etc), and not prevalence.
No, the research is more important. But it's unlikely a genotype for a SNP is causing much mayhem when it's present in 10% of the world's population :p