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Created in 2008, Phoenix Rising is the largest and oldest forum dedicated to furthering the understanding of and finding treatments for complex chronic illnesses such as chronic fatigue syndrome (ME/CFS), fibromyalgia (FM), long COVID, postural orthostatic tachycardia syndrome (POTS), mast cell activation syndrome (MCAS), and allied diseases.
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Proper sodium levels are maintained by the Na/K ATPase pump. Without that pump working, the nerve can't send signals. This pump powers quite a lot in cells.
They certainly could be... but the pump that they hypothesize as broken in muscle cells is in most all cells and does the same job is all cells. That makes it more likely the same pump is at fault everywhere.The high sodium levels was found in the muscles though, the nerves could be a different story.
Exactly!given every thing the body does requires ATP energy, it just seems like there are so many opportunities for damage to mitochondria/ and energy production and every chemical reaction the body does.
What it's not helpful for is showing "the cause" of muscle weakness. It's one part of a very complex picture.
Dr. Scheibenbogen has been looking at autoantibodies on ME/CFS, but they are autoantibodies to a different part of the nervous system than in LEMS. The ME/CFS autoantibodies would mess up the way the blood vessels work, meaning cells don't get enough oxygen, meaning the can't make ATP.
If this is correct, then muscles are weak in ME/CFS because the have no fuel to power contraction. In LEMS, muscles are weak because the signal to contract isn't getting sent properly. Dr. S's hypothesis would fit with excess sodium in muscle cells, because the pump that is supposed to get rid of the sodium can't run, because it doesn't have any fuel either.
When you referred to Dr. Scheibenbogen's autoantibodies, did you mean the anti-muscarinic Abs, or the alpha & beta-adrenergic Abs, or both kinds? (meaning both muscarinic and adrenergic)
I´m not well, Have the nasty flu.
Dr. S hypothesizes (with all those receptors you mentioned) that the breakdown is in the nervous system itself. Part of that, with the muscarinic receptor breakdown, is the inability to received an acetylcholine signal In LEMS, it's the interface between the nervous system and muscular system that breaks. So it's the place the breakdown happens that's different, as well as the signal that's getting sent (or not).
ER yesterday. Blood test and MRI, diagnosis: Respiratory Syncityal Virus A.