Systematic review and meta-analysis of cognitive impairment in ME/CFS (Sebaiti et al., 2022)

Pyrrhus

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Systematic review and meta-analysis of cognitive impairment in ME/CFS (Sebaiti et al., 2022)
https://doi.org/10.1038/s41598-021-04764-w

From the European Network On ME/CFS (EUROMENE).

Excerpt:
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is commonly associated with cognitive complaints. To bring out the neuropsychological symptomatology inherent to ME/CFS, we conducted a systematic review according to PRISMA and MOOSE guidelines of the literature through the analysis of 764 studies published between 1988 and 2019 by using PubMed Central website and Clarivate analytics platform. We performed a meta-analysis to delineate an idea of the neuropsychological profile inherent in ME/CFS.

The clinical picture typically affects visuo-spatial immediate memory (g = − 0.55, p = 0.007), reading speed (g = − 0.82, p = 0.0001) and graphics gesture (g = − 0.59, p = 0.0001). Analysis also revealed difficulties in several processes inherent in episodic verbal memory (storage, retrieval, recognition) and visual memory (recovery) and a low efficiency in attentional abilities. Executive functions seemed to be little or not affected and instrumental functions appeared constantly preserved.

With regard to the complexity and heterogeneity of the cognitive phenotype, it turns out that determining a sound clinical picture of ME/CFS cognitive profile must go through a neuropsychological examination allowing a complete evaluation integrating the notion of agreement between the choice and the number of tests and the complexity intrinsic to the pathology.
(spacing added for readability)
 

Pyrrhus

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Other papers by EUROMENE:

European Network on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (EUROMENE): Expert Consensus on the Diagnosis, Service Provision, and Care of People with ME/CFS in Europe (Nacul et al., 2021)
https://forums.phoenixrising.me/thr...atures-and-diagnosis-2021.83108/#post-2343830

Cytomegalovirus, Epstein-Barr Virus and Human Herpesvirus 6 Infections in Patients with Myalgic Еncephalomyelitis/Chronic Fatigue Syndrome (Shikova et al., 2020)
https://forums.phoenixrising.me/thr...man-herpesvirus-6-infections-in-me-cfs.79373/

A Literature Review of GP Knowledge and Understanding of ME/CFS: A Report from the Socioeconomic Working Group of the European Network on ME/CFS (EUROMENE) (Pheby et al., 2021)
https://forums.phoenixrising.me/thr...atures-and-diagnosis-2021.83108/#post-2325620

Perceptions of European ME/CFS Experts Concerning Knowledge and Understanding of ME/CFS among Primary Care Physicians in Europe: A Report from the European ME/CFS Research Network (EUROMENE) (Cullinan et al., 2021)
https://forums.phoenixrising.me/thr...atures-and-diagnosis-2021.83108/#post-2325615

The Role of Prevention in Reducing the Economic Impact of ME/CFS in Europe: A Report from the Socioeconomics Working Group of the European Network on ME/CFS (EUROMENE) (Pheby et al., 2021)
https://forums.phoenixrising.me/thr...atures-and-diagnosis-2021.83108/#post-2338282
 
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"Executive Functions seemed to be little or not affected...."

Oh?

If:

Executive functions include initiation, inhibition, mental flexibility, novel problem solving, planning, emotion regulation, and self-awareness. These cognitive functions are necessary for goal-directed behavior. (some reference says)....

I don' t understand what they mean.

We are still self aware, mostly.....but...problem solving? planning? ....that is very impaired around here....
 

Consul

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"Executive Functions seemed to be little or not affected...."

Oh?

If:

Executive functions include initiation, inhibition, mental flexibility, novel problem solving, planning, emotion regulation, and self-awareness. These cognitive functions are necessary for goal-directed behavior. (some reference says)....

I don' t understand what they mean.

We are still self aware, mostly.....but...problem solving? planning? ....that is very impaired around here....
Sounds like more evidence that its not a psychological disorder when pwme have all those executive function skills intact: mental flexibility, problem solving, emotion regulation.