Latest summary from XMRV and Immune System of CFS patients in Barcelona by Irsi Caixa
Presentation of Dr. Juli Blanco
With regard to the detection of retrovirus XMRV, Dr. Juli Blanco words were prudent denoting the wisdom of scientists.
Basically They confirm that YES, they have found XMRV, although depending on the technique applied, they have found it in 7, 3 and two patients respectively.
The worst part is that the lack of standardized methods for the test, as Dr. Blanco himself commented, that is the reason of disagreements between the different scientists who are lagging behind XMRV.
Obviously, if there is no funding, no research, as is happening to themselves as well, Can Ruti researchers said.
They have been able to not only detect XMRV sequences in patients with ME / CFS, AIDS patients and healthy people, but the Dr. Cabrera has been able to infect, in the laboratory, human tonsil tissue. It is therefore, an infectious virus for the human species. Nonetheless, with this study so limited in funding and number of participants, there are many things to know:
- How is transmitted (although I would think that like other retroviruses, blood, semen, fluids)
- If the in vitro antiretrovirals used (AZT, Ral, Ten) will also work in vivo (in people)
- If Antiretrovirals will work on a virus, that we still do not know if it acts like HIV (ie infecting cell and destroy it) or as the HTLV (another retrovirus that immortalizes cells and provoque cancer).
In terms of infectiousness and prophylactic measures, He recommends the use of condoms during casual encounters, which LigaSFC and ASSSEM recommend that prophylaxis in all cases.
As for the
immune system of patients with CFS / ME
Well, we knew this would be the "hot potato".
Not surprisingly, the 9 ASSSEM components, some of which are also part of the LigaSFC as its president and vice president, Ldia Moterde, came with T-shirts that said: SFC = IMMUNODEFICIENCY T8
ALL THE IMMUNE CELLS show abnormalities (B Cel, T and NK Cel)
-
B cells are found in small amounts as well as the IgG they produce. He details even more saying that both IgG's cells are found in small amounts those that could be produced and those being produced at that moment.
- The
NK cells (NK or Natural Killer Cells). They maintain baseline function unaltered, ie perform their function of cell destruction. Nonetheless there are two abnormalities in patients with CFS / ME: A degree of activation slightly above normal and A marked reduction of CD57 in the 11 patients analyzed, so that could be used as a marker to validate these patients, according to Dr. Blanco.
- T cells, or
CD4 (Or T4) are divided to a slower pace (unlike the case of HIV). The
CD 8 (T8 or those of T) have two abnormalities: they also divided more slowly (although not as much as CD4) and they present in a very high quantity a marker called CD5 Bright whose presence indicates ANERGY, which is understood as a lack of response by these T cells in the presence of pathogens and / or uncontrolled growth of cells (cancer).
Therefore these would be the first biomarkers for CFS / ME:
1.-Marked decrease in CD 57 in NK
2.-Pattern of anergy with high amount of CD5 Bright on CD8 (T8)
Source: LigaSFC:
http://ligasfc.org/index.php?name=News&file=article&sid=379
If you want to support Irsi Caixa progress in their studies XMRV and the immune system of patients with CFS can make a donation to the following account:
Account No: 2100 0325 05 41 02001422
Concept: SFC XMRV STUDY
Beneficiary: Foundation IrsiCaixa
Address: Carretera de Canyet s / n 08916 Badalona (Barcelona)
Contact: Lourdes Grau
lgrau@irsicaixa.es
The Ministry has denied Irsi Caixa Grant to further investigate the XMRV and the damage it can cause the immune system, we ask you to sign these petitions to the Government:
http://actuable.es/peticiones/pedimos-al-gobierno-financiar-estudios-el-nuevo-retrovirus
http://www.petitionbuzz.com/petitions/xmrv
