Sildenafil on its effects on Fatigue, Cerebral Blood Flow in ME/CFS

[sb4]

@kushami thanks for tagging me!
I did actually try tadalafil in I think October for a few doses. I felt maybe a little more relaxed but I'm not sure. Erections came easier so it worked in that sense.

 

[kushami]

My tadalafil experiment had mixed results. Like the other vasodilators I’ve tried, it definitely helped my cerebral blood flow (bearing in mind that I have OCHOS, not ME/CFS, but that some or indeed many people with ME/CFS may have OCHOS).

However, the side effects were worse than my usual vasodilators (amlodipine plus candesartan). I had aching legs, bad enough to keep me awake and need OTC painkillers every day, and I felt faint and a bit vomitous. (Also had a slight headache and chills, which I could have put up with had all else been well.)

So I have gone back to my usual combo.

Link to OCHOS info:
https://pubmed.ncbi.nlm.nih.gov/26909037/