Sildenafil on its effects on Fatigue, Cerebral Blood Flow in ME/CFS

[sb4]

@kushami thanks for tagging me!
I did actually try tadalafil in I think October for a few doses. I felt maybe a little more relaxed but I'm not sure. Erections came easier so it worked in that sense.

 

[kushami]

My tadalafil experiment had mixed results. Like the other vasodilators I’ve tried, it definitely helped my cerebral blood flow (bearing in mind that I have OCHOS, not ME/CFS, but that some or indeed many people with ME/CFS may have OCHOS).

However, the side effects were worse than my usual vasodilators (amlodipine plus candesartan). I had aching legs, bad enough to keep me awake and need OTC painkillers every day, and I felt faint and a bit vomitous. (Also had a slight headache and chills, which I could have put up with had all else been well.)

So I have gone back to my usual combo.

Link to OCHOS info:
https://pubmed.ncbi.nlm.nih.gov/26909037/

 

[kushami]

Just wanted to add that I tried tadalafil again, on a whim. This time, I didn't notice any adverse effects – I think I took a lower dose. Previously I had been a bit unsure about taking a lower dose because the pills weren't scored, but this time I just went for it.

It did seem to help but no particular "wow factor" when compared to the many other vasodilators that I have tried in terms of targeting the brain, at least as far as I can tell.

I am at a bit of a standstill with medications at the moment. Until I can measure cerebral blood flow (Lumia device or similar home option), there's not much more testing I can do.

Am focusing on the auto-immune side of things so perhaps I won't need as much vasodilation in the future.