30 y/o male, sick for 14 months now with a myriad of symptoms. Have been seen in all the major Boston hospitals by 35+ specialists...etc. etc. Wont go in to full story or all the testing and results here, but in regards to B12. I do have many of the symptoms of B12 deficiency.
However when tested serum levels are always mid-range (usually around 500), MMA is always low but homocysteine is always slightly raised (around 15 range 0-12). MTFHR I am only 1298AC the heterozygous, NO 677. With these findings and my symptoms/lack of firm diagnosis I was able to get my doc to order some other related labs. Here were the results of those:
ANA: Neg
Gastric Paritel Cell Ab: Neg
Fasting Gastrin: 15 pg/mL Range: <101
RBC, HGB, HCT: always just at lowest level of "normal" or just below
B12: 514 Range: 180-914 pg/mL
B12 Binding Capacity: 480 'LOW' Range: 650-1340 pg/mL
My question is, what do these indicate? Given the IF, fasting gastrin and gastric parietal ab's, PA is all but ruled out. However, the low b12 binding test results, if I understand things correctly, suggests that while I may be getting B12 from my diet, my body is not utilizing properly? with that said, I wonder why my MMA level is always fine?
The ordering doc was doing it as more of a favor and has no idea what to make of the results.... he has offered to provide b12 injections to see if they help with any of my symptoms.
However when tested serum levels are always mid-range (usually around 500), MMA is always low but homocysteine is always slightly raised (around 15 range 0-12). MTFHR I am only 1298AC the heterozygous, NO 677. With these findings and my symptoms/lack of firm diagnosis I was able to get my doc to order some other related labs. Here were the results of those:
ANA: Neg
Gastric Paritel Cell Ab: Neg
Fasting Gastrin: 15 pg/mL Range: <101
RBC, HGB, HCT: always just at lowest level of "normal" or just below
B12: 514 Range: 180-914 pg/mL
B12 Binding Capacity: 480 'LOW' Range: 650-1340 pg/mL
My question is, what do these indicate? Given the IF, fasting gastrin and gastric parietal ab's, PA is all but ruled out. However, the low b12 binding test results, if I understand things correctly, suggests that while I may be getting B12 from my diet, my body is not utilizing properly? with that said, I wonder why my MMA level is always fine?
The ordering doc was doing it as more of a favor and has no idea what to make of the results.... he has offered to provide b12 injections to see if they help with any of my symptoms.