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What is your homocysteine value?I'm still trying to understand my snp's and methylation, and one thing that's really confusing is that it seems that I should have high homocysteine. However, mine's normal... Given my snp's, does normal homocysteine levels indicate anything to me?
It's can help diagnose B12 deficiencies.As best I can tell - other than using homocysteine levels to test risk of clotting? There isn't much about them that helps with chronic health issues.
My homocysteine levels dropped significantly while I got increasingly sicker
It's can help diagnose B12 deficiencies.
No, not zero With zero you'd be in deep dudu... homocysteine is very important in the right amountI was less chronically damaged but much sicker when my homocysteine was...0?. Zero is what I recall it being. I didn't know anything about it, only that being below normal was not good.
No, not zero With zero you'd be in deep dudu...
No in general 6-8 is considered optimal because homocysteine is also a marker for oxydative stress, bad methylation, inflammation etc...Maybe 0, yes! I remember thinking - this cannot be good! Maybe it was a mistake though. Anyway, I just had my homocysteine retested and it's now 9.1 (N= 4.0 - 15.4), which is a relief because I am starting a SMP, so that leaves plenty of room to go down without losing the necessary functions of it.
You didn't show a bottom range for the test you took, unless it's 6? and in that case why would the bottom be considered ideal (ideal for what?) instead of something more in mid-range? I wonder whether those ranges and recommendations may be skewed to cardiovascular disease without regard to other considerations.
No in general 6-8 is considered optimal because values homocysteine is also a marker for oxydative stress, bad methylation, inflammation etc...
Me neither, and so my doc!98.6, WOW! I didn't know it could go that high!
By methylation panel I mean the one recommended by Dr. Rich Van K. here:By methylation panel, can you tell me what that includes?
What is your homocysteine value?
As I wrote in some of the previous posts, I had very high Hcy level which came down pretty quickly with the usual B vitamins but then got stuck at around 15-16.6.8, with a range of 0.0 - 15.0 umol/L... So right in the middle of the range.
what did you do that made you better?
If I take high l-methylfolate to stimulate BH4, then will that mess up something else? that's really what i'm worried about.
@ebeth,I'm still trying to understand my snp's and methylation, and one thing that's really confusing is that it seems that I should have high homocysteine. However, mine's normal... Given my snp's, does normal homocysteine levels indicate anything to me?
thanks
@ebeth,
The supplements that help in this situation are methylB12 (if you tolerate it) and TMG (trymethylglycine). They turn the homocysteine into methionine.
(Just a note, and you probably know this already, with the MTHFR A1298C +/-, you need a good reserve of methylfolate not to have the neuro symptoms (for me that's depression, for others anxiety, etc.). And taking methylB12 will use up more methylfolate than normal, so I think it's important that I take methylfolate when I take methyl B12.)
Hope this helps you understand how your SNPs play in to your homocysteine level.
You know, everyone is so different, it's hard to tell. Folinic acid had that effect on me - could hardly stay awake 20 minutes after I took it. Some things to consider:@Critterina - one more question ... does high-dose methylfolate cause fatigue at first? It was stimulating at first, but I'm out of it today..
thanks again for your help!
@Critterina - I was wondering about methyltrapping - but I still don't understand what it is... too many methyls at once?? or, caused by a snp? (is it comt?) this is so hard w brain fog... sorry..4. Could it be that you're in "methyltrap"? I don't think your "fatigue" is as serious as what Freddd describes, but you could check it out.
To be honest, I'm not sure I really believe the theory behind methyltrap. But some people experience something very bad, and they believe it's when they take too much methylfolate without adequate ways to use it up (which could mean that they have the MTHFR A1298C SNP and/or MTRR - those limit conversion of methylfolate to folinic acid and THF respectively). You can take MethylB12 to overcome the MTRR; not sure there's much to do to increase the conversion to folinic acid if you have the MTHFR A1298C. Look up the symptoms, though. I'm not sure yours match.@Critterina - I was wondering about methyltrapping - but I still don't understand what it is... too many methyls at once?? or, caused by a snp? (is it comt?) this is so hard w brain fog... sorry..